Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Christine Lafleur"'
Publikováno v:
Molecular Metabolism, Vol 59, Iss , Pp 101463- (2022)
Objective: Parental environmental exposures can strongly influence descendant risks for adult disease. How paternal obesity changes the sperm chromatin leading to the acquisition of metabolic disease in offspring remains controversial and ill-defined
Externí odkaz:
https://doaj.org/article/c4c9fe4fe9464ece98b872aa65f85a37
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100602- (2021)
Summary: In the field of epigenetic inheritance, delineating molecular mechanisms implicated in the transfer of paternal environmental conditions to descendants has been elusive. This protocol details how to track sperm chromatin intergenerationally.
Externí odkaz:
https://doaj.org/article/4749a90c71c44dde803261af8d75dd75
Publikováno v:
Nucleic Acids Research
Advancing the molecular knowledge surrounding fertility and inheritance has become critical given the halving of sperm counts in the last 40 years, and the rise in complex disease which cannot be explained by genetics alone. The connection between bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c64e5b86f48a1edc10ad85355fceddc
https://doi.org/10.1093/nar/gkaa712
https://doi.org/10.1093/nar/gkaa712
ObjectiveParental environmental exposures can strongly influence descendant risks for adult disease. How paternal obesity changes the sperm chromatin leading to the acquisition of metabolic disease in offspring remains controversial and ill-defined.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96fd4bc622098a0858ec0a4488712206
https://doi.org/10.1101/2021.09.09.459659
https://doi.org/10.1101/2021.09.09.459659
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100602-(2021)
STAR Protocols
STAR Protocols
Summary In the field of epigenetic inheritance, delineating molecular mechanisms implicated in the transfer of paternal environmental conditions to descendants has been elusive. This protocol details how to track sperm chromatin intergenerationally.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab011f625603176c7f49c9cfea69af8b
http://www.sciencedirect.com/science/article/pii/S2666166721003099
http://www.sciencedirect.com/science/article/pii/S2666166721003099
Autor:
Christine Lafleur, Manuelle Landry-Cuerrier, Murray M. Humphries, Sarah Kimmins, Marianne Gagnon
Publikováno v:
Am J Physiol Regul Integr Comp Physiol
Hibernators suppress physiological processes when expressing torpor, yet little is known about the effects of torpor on male reproductive physiology. Studies of hibernating mammals suggest that deep torpor negatively impacts spermatogenesis and that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c37c6045ff59135e77e21410c84fe25
https://pubmed.ncbi.nlm.nih.gov/32783688
https://pubmed.ncbi.nlm.nih.gov/32783688
Publikováno v:
International Journal of Hydrogen Energy. 42:7529-7535
NFPA 2, Hydrogen Technologies Code, allows the use of risk-informed approaches to permitting hydrogen fueling installations, through the use of performance-based evaluations of specific hydrogen hazards. However, the hydrogen fueling industry in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3c313ed2937cf3dcf63ec3859223e25
https://doi.org/10.1016/j.ijhydene.2016.06.167
https://doi.org/10.1016/j.ijhydene.2016.06.167
Autor:
Trygve Skjold, Angela Christine LaFleur, D. Siccama, Helene Hisken, Andrea Brambilla, Prankul Middha, Katrina M. Groth
Publikováno v:
International Journal of Hydrogen Energy. 42:7721-7730
This paper introduces the 3D risk management (3DRM) concept, with particular emphasis on hydrogen installations (Hy3DRM). The 3DRM framework entails an integrated solution for risk management that combines a detailed site-specific 3D geometry model,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94ba92edbe626488d7b9d22e71492329
https://doi.org/10.1016/j.ijhydene.2016.07.006
https://doi.org/10.1016/j.ijhydene.2016.07.006
Autor:
Julie Brind’Amour, Ariane Lismer, Sarah Kimmins, Christine Lafleur, Vanessa Dumeaux, Romain Lambrot, Matthew C. Lorincz
Publikováno v:
Developmental Cell. 56:671-686.e6
Summary A father's lifestyle impacts offspring health; yet, the underlying molecular mechanisms remain elusive. We hypothesized that a diet that changes methyl donor availability will alter the sperm and embryo epigenomes to impact embryonic gene exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b85610a79681cd2210b3741036ef3702
https://doi.org/10.1016/j.devcel.2021.01.014
https://doi.org/10.1016/j.devcel.2021.01.014
Autor:
Angela Christine LaFleur
The objective of this project was to devolop a plan for modifying the Turbulent Combustion Laboratory (TCL) with the necessary infrastructure to produce a cold (near liquid temperature) hydrogen jet. The necessary infrastructure has been specified an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3ab0c0f4084e55eb25756c159c85512
https://doi.org/10.2172/1234187
https://doi.org/10.2172/1234187