Zobrazeno 1 - 10
of 259
pro vyhledávání: '"Christine Ladd"'
Autor:
Michael Yao, Jason Daniels, Luke Grosvenor, Valerie Morrill, Jason I. Feinberg, Kelly M. Bakulski, Joseph Piven, Heather C. Hazlett, Mark D. Shen, Craig Newschaffer, Kristen Lyall, Rebecca J. Schmidt, Irva Hertz-Picciotto, Lisa A. Croen, M. Daniele Fallin, Christine Ladd-Acosta, Heather Volk, Kelly Benke
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Background Common genetic variation has been shown to account for a large proportion of ASD heritability. Polygenic scores generated for autism spectrum disorder (ASD-PGS) using the most recent discovery data, however, explain less variance
Externí odkaz:
https://doaj.org/article/065b3e24ae6742c08b0d1d741348b431
Autor:
Fang Fang, Linran Zhou, Wei Perng, Carmen J. Marsit, Anna K. Knight, Andres Cardenas, Max T. Aung, Marie-France Hivert, Izzuddin M. Aris, Jaclyn M. Goodrich, Alicia K. Smith, Abigail Gaylord, Rebecca C. Fry, Emily Oken, George O’Connor, Douglas M. Ruden, Leonardo Trasande, Julie B. Herbstman, Carlos A. Camargo, Nicole R. Bush, Anne L. Dunlop, Dana M. Dabelea, Margaret R. Karagas, Carrie V. Breton, Carole Ober, Todd M. Everson, Grier P. Page, Christine Ladd-Acosta, on behalf of program collaborators for Environmental influences on Child Health Outcomes
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-14 (2023)
Abstract Background Epigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic clocks in gestational and chronological age determination. Results Our study used data from seven tissue types on
Externí odkaz:
https://doaj.org/article/ba76599e9e1d4dfbacb72eaf17f477e9
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-14 (2023)
Abstract Background Acetaminophen is a commonly used medication by pregnant women and is known to cross the placenta. However, little is known about the biological mechanisms that regulate acetaminophen in the developing offspring. Cytochrome 2E1 (CY
Externí odkaz:
https://doaj.org/article/de947caa66a1481397e18ab5b7064a1c
Autor:
Emma X Yu, John F Dou, Heather E Volk, Kelly M Bakulski, Kelly Benke, Irva Hertz-Picciotto, Rebecca J Schmidt, Craig J Newschaffer, Jason I Feinberg, Jason Daniels, Margaret Daniele Fallin, Christine Ladd-Acosta, Ghassan B Hamra
Publikováno v:
Environmental Health Insights, Vol 18 (2024)
Background: Prenatal exposure to metals is hypothesized to be associated with child autism. We aim to investigate the joint and individual effects of prenatal exposure to urine metals including lead (Pb), mercury (Hg), manganese (Mn), and selenium (S
Externí odkaz:
https://doaj.org/article/4be21fe5ede3449c920059b750726cca
Autor:
Catherine M. Bulka, Todd M. Everson, Amber A. Burt, Carmen J. Marsit, Margaret R. Karagas, Kristen E. Boyle, Sierra Niemiec, Katerina Kechris, Elizabeth J. Davidson, Ivana V. Yang, Jason I. Feinberg, Heather E. Volk, Christine Ladd-Acosta, Carrie V. Breton, T. Michael O’Shea, Rebecca C. Fry
Publikováno v:
Epigenetics, Vol 18, Iss 1 (2023)
The placenta undergoes many changes throughout gestation to support the evolving needs of the foetus. There is also a growing appreciation that male and female foetuses develop differently in utero, with unique epigenetic changes in placental tissue.
Externí odkaz:
https://doaj.org/article/ac82bc0e677b4fe1971c034cf1d44fb9
Autor:
Ashley Y. Song, Catherine M. Bulka, Sierra S. Niemiec, Katerina Kechris, Kristen E. Boyle, Carmen J. Marsit, T. Michael O’Shea, Rebecca C. Fry, Kristen Lyall, M. Daniele Fallin, Heather E. Volk, Christine Ladd-Acosta
Publikováno v:
Epigenetics, Vol 18, Iss 1 (2023)
Background: ‘Epigenetic clocks’ have been developed to accurately predict chronologic gestational age and have been associated with child health outcomes in prior work. Methods: We meta-analysed results from four prospective U.S cohorts investiga
Externí odkaz:
https://doaj.org/article/9b63eea7be7344c1b85939aa2c1aa51c
Autor:
Max T. Aung, Kelly M. Bakulski, Jason I. Feinberg, John F. Dou, John D. Meeker, Bhramar Mukherjee, Rita Loch-Caruso, Christine Ladd-Acosta, Heather E. Volk, Lisa A. Croen, Irva Hertz-Picciotto, Craig J. Newschaffer, M. Daniele Fallin
Publikováno v:
Epigenetics, Vol 17, Iss 3, Pp 253-268 (2022)
The maternal epigenome may be responsive to prenatal metals exposures. We tested whether metals are associated with concurrent differential maternal whole blood DNA methylation. In the Early Autism Risk Longitudinal Investigation cohort, we measured
Externí odkaz:
https://doaj.org/article/6ab337b726944212b28dba1b8fe8089f
Autor:
Adrienne Tin, Pascal Schlosser, Pamela R. Matias-Garcia, Chris H. L. Thio, Roby Joehanes, Hongbo Liu, Zhi Yu, Antoine Weihs, Anselm Hoppmann, Franziska Grundner-Culemann, Josine L. Min, Victoria L. Halperin Kuhns, Adebowale A. Adeyemo, Charles Agyemang, Johan Ärnlöv, Nasir A. Aziz, Andrea Baccarelli, Murielle Bochud, Hermann Brenner, Jan Bressler, Monique M. B. Breteler, Cristian Carmeli, Layal Chaker, Josef Coresh, Tanguy Corre, Adolfo Correa, Simon R. Cox, Graciela E. Delgado, Kai-Uwe Eckardt, Arif B. Ekici, Karlhans Endlich, James S. Floyd, Eliza Fraszczyk, Xu Gao, Xīn Gào, Allan C. Gelber, Mohsen Ghanbari, Sahar Ghasemi, Christian Gieger, Philip Greenland, Megan L. Grove, Sarah E. Harris, Gibran Hemani, Peter Henneman, Christian Herder, Steve Horvath, Lifang Hou, Mikko A. Hurme, Shih-Jen Hwang, Sharon L. R. Kardia, Silva Kasela, Marcus E. Kleber, Wolfgang Koenig, Jaspal S. Kooner, Florian Kronenberg, Brigitte Kühnel, Christine Ladd-Acosta, Terho Lehtimäki, Lars Lind, Dan Liu, Donald M. Lloyd-Jones, Stefan Lorkowski, Ake T. Lu, Riccardo E. Marioni, Winfried März, Daniel L. McCartney, Karlijn A. C. Meeks, Lili Milani, Pashupati P. Mishra, Matthias Nauck, Christoph Nowak, Annette Peters, Holger Prokisch, Bruce M. Psaty, Olli T. Raitakari, Scott M. Ratliff, Alex P. Reiner, Ben Schöttker, Joel Schwartz, Sanaz Sedaghat, Jennifer A. Smith, Nona Sotoodehnia, Hannah R. Stocker, Silvia Stringhini, Johan Sundström, Brenton R. Swenson, Joyce B. J. van Meurs, Jana V. van Vliet-Ostaptchouk, Andrea Venema, Uwe Völker, Juliane Winkelmann, Bruce H. R. Wolffenbuttel, Wei Zhao, Yinan Zheng, The Estonian Biobank Research Team, The Genetics of DNA Methylation Consortium, Marie Loh, Harold Snieder, Melanie Waldenberger, Daniel Levy, Shreeram Akilesh, Owen M. Woodward, Katalin Susztak, Alexander Teumer, Anna Köttgen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Serum urate concentration can be studied in large datasets to find genetic and epigenetic loci that may be related to cardiometabolic traits. Here the authors identify and replicate 100 urate-associated CpGs, which provide insights into urate GWAS lo
Externí odkaz:
https://doaj.org/article/34e5ed6ae9ad4343931586438a0971b4
Autor:
Amin Haghani, Jason I. Feinberg, Kristy C. Lewis, Christine Ladd-Acosta, Richard G. Johnson, Andrew E. Jaffe, Constantinos Sioutas, Caleb E. Finch, Daniel B. Campbell, Todd E. Morgan, Heather E. Volk
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 13, Iss 1, Pp 1-12 (2021)
Abstract Background Prenatal exposure to air pollutants is associated with increased risk for neurodevelopmental and neurodegenerative disorders. However, few studies have identified transcriptional changes related to air pollutant exposure. Methods
Externí odkaz:
https://doaj.org/article/b8f96af460e54690922cc985e5c80965
Autor:
Linda Ejlskov, Jesper N. Wulff, Amy Kalkbrenner, Christine Ladd-Acosta, M. Danielle Fallin, Esben Agerbo, Preben Bo Mortensen, Brian K. Lee, Diana Schendel
Publikováno v:
Biological Psychiatry Global Open Science, Vol 1, Iss 2, Pp 156-164 (2021)
Background: A family history of specific disorders (e.g., autism, depression, epilepsy) has been linked to risk for autism spectrum disorder (ASD). This study examines whether family history data could be used for ASD risk prediction. Methods: We fol
Externí odkaz:
https://doaj.org/article/e51e38f4826f496888cb3dc8e779a73c