Zobrazeno 1 - 10
of 485
pro vyhledávání: '"Christine L. Mummery"'
Autor:
Beatrice Gabbin, Viviana Meraviglia, Maricke L. Angenent, Dorien Ward-van Oostwaard, Wendy Sol, Christine L. Mummery, Ton J. Rabelink, Berend J. van Meer, Cathelijne W. van den Berg, Milena Bellin
Publikováno v:
Materials Today Bio, Vol 23, Iss , Pp 100818- (2023)
Heart and kidney communicate with one another in an interdependent relationship and they influence each other's behavior reciprocally, as pathological changes in one organ can damage the other. Although independent human in vitro models for heart and
Externí odkaz:
https://doaj.org/article/77aeed72b2a14b7c9baa294dfab4caad
Autor:
Dennis M. Nahon, Sravya Ganesh, Francijna E. van den Hil, Christian Freund, Christine L. Mummery, Valeria V. Orlova
Publikováno v:
Stem Cell Research, Vol 71, Iss , Pp 103180- (2023)
Dutch-type cerebral amyloid angiopathy (D-CAA), also known as hereditary cerebral haemorrhage with amyloidosis-Dutch type (HCHWA-D), is an autosomal dominant disorder caused by a G to C transversion in codon 693 of the amyloid precursor protein (APP)
Externí odkaz:
https://doaj.org/article/cfb7b88d0fdd48d5a085207d374e3f15
Autor:
Albert Blanch-Asensio, Babet van der Vaart, Mariana Vinagre, Eline Groen, Christiaan Arendzen, Christian Freund, Niels Geijsen, Christine L. Mummery, Richard P. Davis
Publikováno v:
Stem Cell Research, Vol 66, Iss , Pp 102991- (2023)
STRAIGHT-IN is a platform to precisely integrate DNA payloads into the genome of cells, including hiPSCs. Here, we generated two hiPSC acceptor lines each with one copy of an upgraded landing pad (LP). This improved design allows more efficient (∼1
Externí odkaz:
https://doaj.org/article/1226a2ec50804aaa818af1245a0a9948
On-chip analysis of glycolysis and mitochondrial respiration in human induced pluripotent stem cells
Autor:
Stefanie Fuchs, Ruben W.J. van Helden, Maury Wiendels, Mees N.S. de Graaf, Valeria V. Orlova, Christine L. Mummery, Berend J. van Meer, Torsten Mayr
Publikováno v:
Materials Today Bio, Vol 17, Iss , Pp 100475- (2022)
Recent advances in microfluidic engineering allow the creation of microenvironments in which human cells can be cultured under (patho-)physiological conditions with greater reality than standard plastic tissue culture plates. Microfluidic devices, al
Externí odkaz:
https://doaj.org/article/cd0291a830874cb4afd8c49614c6b254
Autor:
Mohamed Abou-el-Enein, Aris Angelis, Frederick R. Appelbaum, Nancy C. Andrews, Susan E. Bates, Arlene S. Bierman, Malcolm K. Brenner, Marina Cavazzana, Michael A. Caligiuri, Hans Clevers, Emer Cooke, George Q. Daley, Victor J. Dzau, Lee M. Ellis, Harvey V. Fineberg, Lawrence S.B. Goldstein, Stephen Gottschalk, Margaret A. Hamburg, Donald E. Ingber, Donald B. Kohn, Adrian R. Krainer, Marcela V. Maus, Peter Marks, Christine L. Mummery, Roderic I. Pettigrew, Joni L. Rutter, Sarah A. Teichmann, Andre Terzic, Fyodor D. Urnov, David A. Williams, Jedd D. Wolchok, Mark Lawler, Cameron J. Turtle, Gerhard Bauer, John P.A. Ioannidis
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss , Pp 11-14 (2021)
Externí odkaz:
https://doaj.org/article/c3fa45c6e32349f68ffd7fcab701dc16
Autor:
Beatrice Gabbin, Viviana Meraviglia, Christine L. Mummery, Ton J. Rabelink, Berend J. van Meer, Cathelijne W. van den Berg, Milena Bellin
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Heart and kidney diseases cause high morbidity and mortality. Heart and kidneys have vital functions in the human body and, interestingly, reciprocally influence each other’s behavior: pathological changes in one organ can damage the other. Cardior
Externí odkaz:
https://doaj.org/article/157b360d55854f75835e11aed74f1e74
Autor:
Ulgu Arslan, Alessia Moruzzi, Joanna Nowacka, Christine L. Mummery, Dominik Eckardt, Peter Loskill, Valeria V. Orlova
Publikováno v:
Materials Today Bio, Vol 14, Iss , Pp 100259- (2022)
Models of heart disease and drug responses are increasingly based on human pluripotent stem cells (hPSCs) since their ability to capture human heart (dys-)function is often better than animal models. Simple monolayer cultures of hPSC-derived cardiomy
Externí odkaz:
https://doaj.org/article/e02262e66da14e30b503ad44e201cc31
Autor:
Joaquin Montilla-Rojo, Monika Bialecka, Kimberley E. Wever, Christine L. Mummery, Leendert H. J. Looijenga, Bernard A. J. Roelen, Daniela C. F. Salvatori
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3879 (2023)
Pluripotency describes the ability of stem cells to differentiate into derivatives of the three germ layers. In reporting new human pluripotent stem cell lines, their clonal derivatives or the safety of differentiated derivatives for transplantation,
Externí odkaz:
https://doaj.org/article/8a54886de89e48a6b308d2be90296a15
Autor:
Veronika Ramovs, Ignacia Fuentes, Christian Freund, Harald Mikkers, Christine L. Mummery, Karine Raymond
Publikováno v:
Stem Cell Research, Vol 57, Iss , Pp 102582- (2021)
Fibroblasts from two patients carrying a heterozygous mutation in the translation initiation codon (c.2 T > G) of the kelch-like protein 24 (KLHL24) gene were used to generate human induced pluripotent stem cells (hiPSCs), using non-integrating Senda
Externí odkaz:
https://doaj.org/article/4ba238b09fea4e21abaf8fc5682b0447
Autor:
Lettine van den Brink, Karina O. Brandão, Loukia Yiangou, Albert Blanch-Asensio, Mervyn P. H. Mol, Christine L. Mummery, Arie O. Verkerk, Richard P. Davis
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
While rare mutations in ion channel genes are primarily responsible for inherited cardiac arrhythmias, common genetic variants are also an important contributor to the clinical heterogeneity observed among mutation carriers. The common single nucleot
Externí odkaz:
https://doaj.org/article/b3ab6f47f3f748f3a3df91203bd31a56