Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Christine L. Melchior"'
Publikováno v:
Pharmacology Biochemistry and Behavior. 46:309-314
A potential role for central stores of vasopressin in the development of tolerance was studied in the long-term castrate rat. Vasopressin stores in the septal region are known to be dramatically depressed following long-term castration. Sprague-Dawle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886118fec0554ca80c4b50ce1e243394
https://doi.org/10.1016/0091-3057(93)90358-z
https://doi.org/10.1016/0091-3057(93)90358-z
Autor:
Christine L. Melchior, Pamela M. Allen
Publikováno v:
Alcohol. 10:17-20
The handling involved in rectally probing a mouse in order to measure body temperature is a stress which results in an increase in body temperature. However, after an injection of ethanol the fall in body temperature caused by ethanol is exacerbated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aca60156ea888bd79a170118c0e3b1ba
https://doi.org/10.1016/0741-8329(93)90048-s
https://doi.org/10.1016/0741-8329(93)90048-s
Autor:
Christine L. Melchior, Pamela M. Allen
Publikováno v:
Pharmacology Biochemistry and Behavior. 42:605-611
3-alpha-Hydroxy-5-beta-pregnan-20-one [pregnanolone (PA)] and 3-beta-hydroxy-5-pregnen-20-one 3-sulfate [pregnenolone sulfate (PS)] are steroids that have been shown in biochemical studies to be active at the GABA-benzodiazepine-chloride receptor com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9da26c731951b0f7eedbe4c3db295713
https://doi.org/10.1016/0091-3057(92)90005-z
https://doi.org/10.1016/0091-3057(92)90005-z
Publikováno v:
Alcoholism: Clinical and Experimental Research. 15:106-111
The purpose of this investigation was to determine the effect of various acute doses of ethanol (1.0, 3.0, 4.0 g/kg) on the distribution of cardiac output (%CO) and blood flow to the splanchnic vascular bed in conscious male Wistar rats. Regional blo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::983980f3a86432ad92c8d17a0d2f4689
https://doi.org/10.1111/j.1530-0277.1991.tb00526.x
https://doi.org/10.1111/j.1530-0277.1991.tb00526.x
Publikováno v:
Alcoholism: Clinical and Experimental Research. 14:616-622
The purpose of these experiments was to determine whether or not tolerance develops to the effect of 3.0 g/kg ethanol on total and regional splanchnic blood flow in male Wistar rats. The animals were given the Lieber-DeCarli liquid diet containing et
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::556bfe0b16a22f5e04c4571312fc35cc
https://doi.org/10.1111/j.1530-0277.1990.tb01212.x
https://doi.org/10.1111/j.1530-0277.1990.tb01212.x
Publikováno v:
Pharmacology Biochemistry and Behavior. 44:805-807
Working memory is disrupted an Alzheimer's disease and stroke; therefore, any therapeutic drug should deficits in working memory. The win-shift foraging paradigm has been demostrated to be a model of working memory in rats. In the present study, this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0afa7a6a6185e726dfe2742b44feebf
https://doi.org/10.1016/0091-3057(93)90009-i
https://doi.org/10.1016/0091-3057(93)90009-i
Publikováno v:
Journal of gerontology. 49(2)
Because tacrine, a cognitive enhancing agent, was being considered for approval for use in Alzheimer's disease, its possible interaction with ethanol, a commonly used substance to which elderly individuals are generally more sensitive than younger in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67472a3f96ebbe0baedaf4c2bd42b9b0
https://pubmed.ncbi.nlm.nih.gov/8126346
https://pubmed.ncbi.nlm.nih.gov/8126346
Autor:
Christine L. Melchior, R.F. Ritzmann
Publikováno v:
Pharmacology, biochemistry, and behavior. 47(3)
Dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are neurosteroids that have been shown to interact with the GABA system. The present study examined the effects of these compounds in mice on motor activity and behavior in the elevated plus maze.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a16715c934038311030d222137a1b06
https://pubmed.ncbi.nlm.nih.gov/7911573
https://pubmed.ncbi.nlm.nih.gov/7911573
Publikováno v:
Alcohol (Fayetteville, N.Y.). 10(6)
Using a test of working memory which is not influenced by learning, the win-shift foraging paradigm, ethanol was found to produce amnesia in mice. This effect was produced by very low doses of ethanol, 0.5 and 1.5 g/kg, which did not alter motivation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7623bec9473f07c54790ffb528165352
https://pubmed.ncbi.nlm.nih.gov/8123206
https://pubmed.ncbi.nlm.nih.gov/8123206
Publikováno v:
Pharmacology, biochemistry, and behavior. 43(1)
Recent reports have indicated that the neurosteroid dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) interact with the GABAA receptor complex. Because many of the behavioral effects of ethanol and pentobarbital are due to activity at this comple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42a2c84f02c2fb83dcbd8d5db54d3945
https://pubmed.ncbi.nlm.nih.gov/1409808
https://pubmed.ncbi.nlm.nih.gov/1409808