Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Christine L. Hammond"'
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor originally identified as an environmental sensor of xenobiotic chemicals. However, studies have revealed that the AHR regulates crucial aspects of cell growth and metaboli
Externí odkaz:
https://doaj.org/article/a824b0054a2d4e5c815c4d2fc7c351da
Autor:
Steven E. Feldon, Elisa Roztocil, Collynn F. Woeller, Christine L. Hammond, Vardaan Gupta, Mithra O. Gonzalez
Publikováno v:
Surv Ophthalmol
Thyroid eye disease (TED) is an autoimmune disorder that manifests in the orbit. In TED, the connective tissue behind the eye becomes inflamed and remodels with increased fat accumulation and/or increased muscle and scar tissue. As orbital tissue exp
Publikováno v:
Frontiers in toxicology. 4
The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor originally identified as an environmental sensor of xenobiotic chemicals. However, studies have revealed that the AHR regulates crucial aspects of cell growth and metaboli
Autor:
Christine L. Hammond, Elisa Roztocil, Collynn F. Woeller, Steven E. Feldon, Mithra O. Gonzalez
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Thyroid eye disease (TED) affects 25–50% of patients with Graves’ Disease. In TED, collagen accumulation leads to an expansion of the extracellular matrix (ECM) which causes destructive tissue remodeling. The purpose of this study was to investig
Autor:
Steven E. Feldon, Collynn F. Woeller, Elisa Roztocil, Richard P. Phipps, Christine L. Hammond
Publikováno v:
The American Journal of Pathology. 186:3189-3202
Thyroid eye disease (TED) is a degenerative disease that manifests with detrimental tissue remodeling, myofibroblast accumulation, and scarring in the orbit of affected individuals. Currently, there are no effective therapies for TED that target or p
Autor:
Christine L. Hammond, Steven E. Feldon, Elisa Roztocil, Collynn F. Woeller, Mithra O. Gonzalez
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Thyroid eye disease (TED) is a condition that causes the tissue behind the eye to become inflamed and can result in excessive fatty tissue accumulation in the orbit. Two subpopulations of fibroblasts reside in the orbit: those that highly exp
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose To investigate the molecular pathways that drive thyroid stimulating hormone receptor (TSHR)-induced cellular proliferation in orbital fibroblasts (OFs) from thyroid eye disease (TED) patients. Methods Orbital fibroblasts from TED and non-TED
Autor:
Christine L. Hammond, Richard P. Phipps, Elisa Roztocil, Collynn F. Woeller, Steven E. Feldon
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 9, p e0222779 (2019)
PLoS ONE, Vol 14, Iss 9, p e0222779 (2019)
Thyroid eye disease (TED) can lead to scar formation and tissue remodeling in the orbital space. In severe cases, the scarring process leads to sight-threatening pathophysiology. There is no known effective way to prevent scar formation in TED patien
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1778:2413-2420
The proteins responsible for reduced glutathione (GSH) export under both basal conditions and in cells undergoing apoptosis have not yet been identified, although recent studies implicate some members of the multidrug resistance-associated protein fa
Autor:
Suzanne M. Krance, Christine L. Hammond, Jennifer B. Cunningham, Nazzareno Ballatori, Rosemarie Marchan
Publikováno v:
Toxicology and Applied Pharmacology. 204:238-255
The initial step in reduced glutathione (GSH) turnover in all mammalian cells is its transport across the plasma membrane into the extracellular space; however, the mechanisms of GSH transport are not clearly defined. GSH export is required for the d