Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Christine L O'Keefe"'
Autor:
Fabiola Traina, Valeria Visconte, Anna M Jankowska, Hideki Makishima, Christine L O'Keefe, Paul Elson, Yingchun Han, Fred H Hsieh, Mikkael A Sekeres, Raghuveer Singh Mali, Matt Kalaycio, Alan E Lichtin, Anjali S Advani, Hien K Duong, Edward Copelan, Reuben Kapur, Sara T Olalla Saad, Jaroslaw P Maciejewski, Ramon V Tiu
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43090 (2012)
We hypothesized that analysis of single nucleotide polymorphism arrays (SNP-A) and new molecular defects may provide new insight in the pathogenesis of systemic mastocytosis (SM). SNP-A karyotyping was applied to identify recurrent areas of loss of h
Externí odkaz:
https://doaj.org/article/3bd5ec1f93014f6daa4b072541ae3ce8
Autor:
Jaroslaw P. Maciejewski, Michael A. McDevitt, Xiao Fei Wang, Mikkael A. Sekeres, Hadrian Szpurka, Manjot S. Rataul, Hideki Makishima, Christine L. O'Keefe, Lukasz P. Gondek, Andrew J. Dunbar
Supplementary Table A from 250K Single Nucleotide Polymorphism Array Karyotyping Identifies Acquired Uniparental Disomy and Homozygous Mutations, Including Novel Missense Substitutions of c-Cbl, in Myeloid Malignancies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68884e8dd3601fd8a371a4ab6041f642
https://doi.org/10.1158/0008-5472.22375763
https://doi.org/10.1158/0008-5472.22375763
Autor:
Jaroslaw P. Maciejewski, Michael A. McDevitt, Xiao Fei Wang, Mikkael A. Sekeres, Hadrian Szpurka, Manjot S. Rataul, Hideki Makishima, Christine L. O'Keefe, Lukasz P. Gondek, Andrew J. Dunbar
Supplementary Figure A from 250K Single Nucleotide Polymorphism Array Karyotyping Identifies Acquired Uniparental Disomy and Homozygous Mutations, Including Novel Missense Substitutions of c-Cbl, in Myeloid Malignancies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7457e2da63a3c3c31dd73545daadc78a
https://doi.org/10.1158/0008-5472.22375766.v1
https://doi.org/10.1158/0008-5472.22375766.v1
Autor:
Manuel G. Afable, Mohammed Shaik, Yuka Sugimoto, Paul Elson, Michael Clemente, Hideki Makishima, Mikkael A. Sekeres, Alan Lichtin, Anjali Advani, Matt Kalaycio, Ramon V. Tiu, Christine L. O’Keefe, Jaroslaw P. Maciejewski
Publikováno v:
Haematologica, Vol 96, Iss 9 (2011)
Background A combination of horse anti-thymocyte globulin and cyclosporine produces responses in 60–70% of patients with severe aplastic anemia. We performed a phase II study of rabbit anti-thymocyte globulin and cyclosporine as first-line therapy
Externí odkaz:
https://doaj.org/article/7c26f0276b1e4d5c802c5ea75f3f6f44
Autor:
Yuka Sugimoto, Matt Kalaycio, Ramon V. Tiu, Anna M. Jankowska, Edward A. Copelan, Hadrian Szpurka, Valeria Visconte, Christine L. O'Keefe, Hideki Makishima, Anjali S. Advani, S. T. Olalla Saad, Fabiola Traina, Jaroslaw P. Maciejewski, Ali Tabarroki, Mikkael A. Sekeres, Edy Hasrouni, Yogen Saunthararajah, Paul Elson
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
We hypothesized that specific molecular mutations are important biomarkers for response to DNA methyltransferase inhibitors (DNMT inhibitors) and may have prognostic value in patients with myelodysplastic syndromes (MDS). Mutational analysis was perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a264302f71293fd146d6cc3e57146013
https://doi.org/10.1038/leu.2013.269
https://doi.org/10.1038/leu.2013.269
Autor:
Michael A. McDevitt, Yuka Sugimoto, Jaroslaw P. Maciejewski, Andrew Dunbar, Sergei Vatolin, Naoko Hosono, Bartlomiej P Przychodzen, Alan F. List, Mikkael A. Sekeres, Venugopalan Cheriyath, Zhenbo Hu, Hideki Makishima, Yogen Saunthararajah, Frederic J. Reu, Reda Z. Mahfouz, Shahper N. Khan, Christine L. O'Keefe, Alison R. Moliterno, Anna M. Jankowska
Publikováno v:
Leukemia. 27:1301-1309
Polycomb repressive complex 2 (PRC2) is involved in trimethylation of histone H3 lysine 27 (H3K27), chromatin condensation and transcriptional repression. The silencing function of PRC2 complex is mostly attributed to its intrinsic activity for methy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc7a28ed7b9127586e50cff9922f99f5
https://doi.org/10.1038/leu.2013.80
https://doi.org/10.1038/leu.2013.80
Autor:
Anna M. Jankowska, Andrea Pellagatti, Jacqueline Boultwood, Alison R. Moliterno, Hideki Makishima, Azim M Mohamedali, Alan F. List, Austin G. Kulasekararaj, Jaroslaw P. Maciejewski, Andres Jerez, Bartlomiej P Przychodzen, Mikkael A. Sekeres, Yuka Sugimoto, Ramon V. Tiu, Amit Verma, Kathy L. McGraw, Seiji Kojima, Hideki Muramatsu, Valeria Visconte, Michael A. McDevitt, Ghulam J. Mufti, Christine L. O'Keefe
Loss of heterozygosity affecting chromosome 7q is common in acute myeloid leukemia and myelodysplastic syndromes, pointing toward the essential role of this region in disease phenotype and clonal evolution. The higher resolution offered by recently d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ecf8566733871fb7ebd477d2644a62
https://doi.org/10.1182/blood-2011-12-397620
https://doi.org/10.1182/blood-2011-12-397620
Autor:
John Barnard, Jarnail Singh, Manoj Bupathi, Heesun J. Rogers, Hideki Makishima, Anjali S. Advani, Edward A. Copelan, Hadrian Szpurka, Sami Osman, Anna M. Jankowska, Christine L. O'Keefe, James E. McMahon, Richard A. Padgett, Kazunori Koide, Kyoichi Isono, Mikkael A. Sekeres, Fabiola Traina, Valeria Visconte, Yogen Saunthararajah, Andres Jerez, Jaroslaw P. Maciejewski, Ramon V. Tiu, Haruhiko Koseki
Publikováno v:
Blood. 120:3173-3186
Whole exome/genome sequencing has been fundamental in the identification of somatic mutations in the spliceosome machinery in myelodysplastic syndromes (MDSs) and other hematologic disorders. SF3B1, splicing factor 3b subunit 1 is mutated in 60%-80%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37745ed5ef81b87ecd29ced8d11c04a
https://doi.org/10.1182/blood-2012-05-430876
https://doi.org/10.1182/blood-2012-05-430876
Autor:
Yogenthiran Saunthararajah, J.P. Maciejewski, Hadrian Szpurka, Christine L. O'Keefe, Hideki Muramatsu, Michael J. Clemente, Hideki Makishima, Yuka Sugimoto, Kwok Peng Ng
Publikováno v:
Leukemia. 26:1547-1554
Recurrent homozygous CBL-inactivating mutations in myeloid malignancies decrease ubiquitin ligase activity that inactivates SRC family kinases (SFK) and receptor tyrosine kinases (RTK). However, the most important SFK and RTK affected by these mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f00427d6c3b660ab9017ad92f2a3936d
https://doi.org/10.1038/leu.2012.7
https://doi.org/10.1038/leu.2012.7
Autor:
Hirotoshi Sakaguchi, Hideki Makishima, Yoshiyuki Takahashi, Hideki Muramatsu, Akira Shimada, Koji Kato, Hadrian Szpurka, Seiji Kojima, Sayoko Doisaki, Christine L. O'Keefe, Jaroslaw P. Maciejewski, Hitoshi Kiyoi, Asahito Hama, Monika Jasek, Nobuhiro Watanabe, Tomoki Naoe, Yuka Sugimoto
Publikováno v:
British Journal of Haematology. 156:316-325
While acute megakaryoblastic leukaemia (AMKL) occurs in children with (DS-AMKL) and without (paediatric non-DS-AMKL) Down syndrome, it can also affect adults without DS (adult non-DS-AMKL). We have analysed these subgroups of patients (11 children wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7229850d7dacb54217f71415cf87c35d
https://doi.org/10.1111/j.1365-2141.2011.08948.x
https://doi.org/10.1111/j.1365-2141.2011.08948.x