Zobrazeno 1 - 10
of 484
pro vyhledávání: '"Christine L Mummery"'
Autor:
Marga J Bouma, Christian Freund, Adriaan P IJzerman, Dorret I Boomsma, Christine L Mummery, Karine Raymond
Publikováno v:
Stem Cell Research, Vol 41, Iss , Pp - (2019)
Lymphoblast cells from four individuals of a family of two genetically unrelated parents and their monozygotic twins were used to generate integration-free human induced pluripotent stem cells (hiPSCs). Reprogramming factors were delivered by co-elec
Externí odkaz:
https://doaj.org/article/6f0d0c1dd6694eb997fd28c6d045c575
Autor:
Harsha D Devalla, Roselle Gélinas, Elhadi H Aburawi, Abdelaziz Beqqali, Philippe Goyette, Christian Freund, Marie‐A Chaix, Rafik Tadros, Hui Jiang, Antony Le Béchec, Jantine J Monshouwer‐Kloots, Tom Zwetsloot, Georgios Kosmidis, Frédéric Latour, Azadeh Alikashani, Maaike Hoekstra, Jurg Schlaepfer, Christine L Mummery, Brian Stevenson, Zoltan Kutalik, Antoine AF de Vries, Léna Rivard, Arthur AM Wilde, Mario Talajic, Arie O Verkerk, Lihadh Al‐Gazali, John D Rioux, Zahurul A Bhuiyan, Robert Passier
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 12, Pp 1390-1408 (2016)
Abstract Genetic causes of many familial arrhythmia syndromes remain elusive. In this study, whole‐exome sequencing (WES) was carried out on patients from three different families that presented with life‐threatening arrhythmias and high risk of
Externí odkaz:
https://doaj.org/article/fbd3c37951794a57a006bfdb37a6a0d0
Autor:
Luca Sala, Zhiyi Yu, Dorien Ward‐van Oostwaard, Jacobus PD van Veldhoven, Alessandra Moretti, Karl‐Ludwig Laugwitz, Christine L Mummery, Adriaan P IJzerman, Milena Bellin
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 9, Pp 1065-1081 (2016)
Abstract Long‐QT syndrome (LQTS) is an arrhythmogenic disorder characterised by prolongation of the QT interval in the electrocardiogram, which can lead to sudden cardiac death. Pharmacological treatments are far from optimal for congenital forms o
Externí odkaz:
https://doaj.org/article/767b30a7cd6e491aa4968dd31eb2d71b
Autor:
Arti A Ramkisoensing, Daniël A Pijnappels, Saïd F A Askar, Robert Passier, Jim Swildens, Marie José Goumans, Cindy I Schutte, Antoine A F de Vries, Sicco Scherjon, Christine L Mummery, Martin J Schalij, Douwe E Atsma
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24164 (2011)
Mesenchymal stem cells (MSCs) show unexplained differences in differentiation potential. In this study, differentiation of human (h) MSCs derived from embryonic, fetal and adult sources toward cardiomyocytes, endothelial and smooth muscle cells was i
Externí odkaz:
https://doaj.org/article/c6ee5c629f21467ba02a67d6dd875c9c
Autor:
Masataka Fujiwara, Peishi Yan, Tomomi G Otsuji, Genta Narazaki, Hideki Uosaki, Hiroyuki Fukushima, Koichiro Kuwahara, Masaki Harada, Hiroyuki Matsuda, Satoshi Matsuoka, Keisuke Okita, Kazutoshi Takahashi, Masato Nakagawa, Tadashi Ikeda, Ryuzo Sakata, Christine L Mummery, Norio Nakatsuji, Shinya Yamanaka, Kazuwa Nakao, Jun K Yamashita
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16734 (2011)
Induced pluripotent stem cells (iPSCs) are novel stem cells derived from adult mouse and human tissues by reprogramming. Elucidation of mechanisms and exploration of efficient methods for their differentiation to functional cardiomyocytes are essenti
Externí odkaz:
https://doaj.org/article/ebcc9e28bec240eb83991bb68d5b334c
Autor:
Beatrice Gabbin, Viviana Meraviglia, Christine L. Mummery, Ton J. Rabelink, Berend J. van Meer, Cathelijne W. van den Berg, Milena Bellin
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Heart and kidney diseases cause high morbidity and mortality. Heart and kidneys have vital functions in the human body and, interestingly, reciprocally influence each other’s behavior: pathological changes in one organ can damage the other. Cardior
Externí odkaz:
https://doaj.org/article/157b360d55854f75835e11aed74f1e74
Autor:
Phong D. Nguyen, Iris Gooijers, Giulia Campostrini, Arie O. Verkerk, Hessel Honkoop, Mara Bouwman, Dennis E. M. de Bakker, Tim Koopmans, Aryan Vink, Gerda E. M. Lamers, Avraham Shakked, Jonas Mars, Aat A. Mulder, Sonja Chocron, Kerstin Bartscherer, Eldad Tzahor, Christine L. Mummery, Teun P. de Boer, Milena Bellin, Jeroen Bakkers
Publikováno v:
Science, 380(6646), 758-764. American Association for the Advancement of Science
Zebrafish hearts can regenerate by replacing damaged tissue with new cardiomyocytes. Although the steps leading up to the proliferation of surviving cardiomyocytes have been extensively studied, little is known about the mechanisms that control proli
Autor:
Mees N. S. de Graaf, Aisen Vivas, Andries D. van der Meer, Christine L. Mummery, Valeria V. Orlova
Publikováno v:
Micromachines, Vol 13, Iss 8, p 1359 (2022)
Organ-on-chip (OoC) devices are increasingly used to mimic the tissue microenvironment of cells in intact organs. This includes microchannels to mimic, for example, fluidic flow through blood vessels. Present methods for controlling microfluidic flow
Externí odkaz:
https://doaj.org/article/0998b380767740f0bdcac4f5f3ff011e
Autor:
Viviana Meraviglia, Christiaan H. Arendzen, Christian Freund, Douwe E. Atsma, Christine L. Mummery, Milena Bellin
Publikováno v:
Stem Cell Research, Vol 45, Iss , Pp - (2020)
Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) is a malignant channelopathy associated with exercise- and stress-induced cardiac sudden death. The autosomal dominant form of CPVT is due to mutations in the ryanodine receptor 2 (RYR2) ge
Externí odkaz:
https://doaj.org/article/04f096cec0ac49378a48a48f736017ae
Autor:
Verena Schwach, Arie O. Verkerk, Mervyn Mol, Jantine J. Monshouwer-Kloots, Harsha D. Devalla, Valeria V. Orlova, Konstantinos Anastassiadis, Christine L. Mummery, Richard P. Davis, Robert Passier
Publikováno v:
Stem Cell Reports, Vol 9, Iss 6, Pp 1765-1779 (2017)
Summary: Reporter cell lines have already proven valuable in identifying, tracking, and purifying cardiac subtypes and progenitors during differentiation of human pluripotent stem cells (hPSCs). We previously showed that chick ovalbumin upstream prom
Externí odkaz:
https://doaj.org/article/86741319e29f4ce69b257080865b7f66