Zobrazeno 1 - 10
of 200
pro vyhledávání: '"Christine L Hann"'
Autor:
Laura C Cappelli, Patrick M Forde, Ami A Shah, Julie Brahmer, Joseph C Murray, Paola Ghanem, Vincent K Lam, Benjamin P Levy, Kristen A Marrone, Susan C Scott, Josephine L Feliciano, Christine L Hann, David S Ettinger, Christopher Mecoli
Publikováno v:
RMD Open, Vol 9, Iss 4 (2023)
Purpose Concomitant autoimmune rheumatic diseases (ARD) can add morbidity and complicate treatment decisions for patients with lung cancer. We evaluated the tumour characteristics at diagnosis and clinical outcomes in lung cancer patients with or wit
Externí odkaz:
https://doaj.org/article/0a0d1f66575040e49d7c3c68700e07dc
Autor:
Jennifer A MacDiarmid, Veronika Langova, Dale Bailey, Scott T Pattison, Stacey L Pattison, Neil Christensen, Luke R Armstrong, Vatsala N Brahmbhatt, Katarzyna Smolarczyk, Matthew T Harrison, Marylia Costa, Nancy B Mugridge, Ilya Sedliarou, Nicholas A Grimes, Debra L Kiss, Bruce Stillman, Christine L Hann, Gary L Gallia, Robert M Graham, Himanshu Brahmbhatt
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0151832 (2016)
Cytotoxic chemotherapy can be very effective for the treatment of cancer but toxicity on normal tissues often limits patient tolerance and often causes long-term adverse effects. The objective of this study was to assist in the preclinical developmen
Externí odkaz:
https://doaj.org/article/e116e1cea4c448e58b0ddb5f6f713be5
Autor:
I-Mei Siu, Jacob Ruzevick, Qi Zhao, Nick Connis, Yuchen Jiao, Chetan Bettegowda, Xuewei Xia, Peter C Burger, Christine L Hann, Gary L Gallia
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78895 (2013)
Chordomas are rare primary bone tumors that occur along the neuraxis. Primary treatment is surgery, often followed by radiotherapy. Treatment options for patients with recurrence are limited and, notably, there are no FDA approved therapeutic agents.
Externí odkaz:
https://doaj.org/article/6730dfb885de47f5b56a2e97daee58b1
Autor:
Aaron S. Mansfield, David S. Hong, Christine L. Hann, Anna F. Farago, Himisha Beltran, Saiama N. Waqar, Andrew E. Hendifar, Lowell B. Anthony, Matthew H. Taylor, Alan H. Bryce, Scott T. Tagawa, Karl Lewis, Jiaxin Niu, Christine H. Chung, James M. Cleary, Michael Rossi, Carrianne Ludwig, Ricardo Valenzuela, Yan Luo, Rahul Aggarwal
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-7 (2021)
Abstract Delta-like protein 3 (DLL3) is highly expressed in solid tumors, including neuroendocrine carcinomas/neuroendocrine tumors (NEC/NET). Rovalpituzumab tesirine (Rova-T) is a DLL3-targeting antibody-drug conjugate. Patients with NECs and other
Externí odkaz:
https://doaj.org/article/41cea5032a0d44ac9ceef9a9bed44b7a
Autor:
Susan C. Scott, Xiaoshan M. Shao, Noushin Niknafs, Archana Balan, Gavin Pereira, Kristen A. Marrone, Vincent K. Lam, Joseph C. Murray, Josephine L. Feliciano, Benjamin P. Levy, David S. Ettinger, Christine L. Hann, Julie R. Brahmer, Patrick M. Forde, Rachel Karchin, Jarushka Naidoo, Valsamo Anagnostou
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
IntroductionThe magnitude of response to immune checkpoint inhibitor (ICI) therapy may be sex-dependent, as females have lower response rates and decreased survival after ICI monotherapy. The mechanisms underlying this sex dimorphism in ICI response
Externí odkaz:
https://doaj.org/article/2f91c0b2890647729b3fe999f6a97a89
Autor:
Joshua E. Reuss, MD, Emily Brigham, MD, MHS, Kevin J. Psoter, PhD, Khinh Ranh Voong, MD, Bairavi Shankar, BS, David S. Ettinger, MD, Kristen A. Marrone, MD, Christine L. Hann, MD, Benjamin Levy, MD, Josephine L. Feliciano, MD, Julie R. Brahmer, MD, David Feller-Kopman, MD, Andrew D. Lerner, MD, Hans Lee, MD, Lonny Yarmus, DO, Russell K. Hales, MD, Franco D’Alessio, MD, Sonye K. Danoff, MD, PhD, Patrick M. Forde, MBBCH, Karthik Suresh, MD, Jarushka Naidoo, MBBCH, MHS
Publikováno v:
JTO Clinical and Research Reports, Vol 2, Iss 10, Pp 100220- (2021)
Introduction: Checkpoint inhibitor pneumonitis (CIP) is a serious toxicity of anti–programmed death-(ligand) 1 immunotherapy. Whether pretreatment differences in pulmonary function exist in patients who develop CIP is unknown. We analyzed the pulmo
Externí odkaz:
https://doaj.org/article/d916673ba4b249d5ba179b35fe488531
Autor:
Lavanya Sivapalan, Wade T. Iams, Zineb Belcaid, Susan C. Scott, Noushin Niknafs, Archana Balan, James R. White, Prasad Kopparapu, Christopher Cann, Blair V. Landon, Gavin Pereira, Victor E. Velculescu, Christine L. Hann, Christine M. Lovly, Valsamo Anagnostou
Publikováno v:
Clinical Cancer Research. :OF1-OF14
Purpose: Patients with small-cell lung cancer (SCLC) have an exceptionally poor prognosis, calling for improved real-time noninvasive biomarkers of therapeutic response. Experimental Design: We performed targeted error-correction sequencing on 171 se
Autor:
Gary L. Gallia, Ming Zhang, Yi Ning, Michael C. Haffner, Denise Batista, Zev A. Binder, Justin A. Bishop, Christine L. Hann, Ralph H. Hruban, Masaru Ishii, Alison P. Klein, Douglas D. Reh, Lisa M. Rooper, Vafi Salmasi, Rafael J. Tamargo, Qing Wang, Tara Williamson, Tianna Zhao, Ying Zou, Alan K. Meeker, Nishant Agrawal, Bert Vogelstein, Kenneth W. Kinzler, Nickolas Papadopoulos, Chetan Bettegowda
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-6 (2018)
Olfactory neuroblastoma (ONB) is a rare malignant tumor whose genetic basis is poorly understood. Here the authors identify recurrent deletions involving dystrophin in the majority of ONB patient tumors examined.
Externí odkaz:
https://doaj.org/article/666203899eb144b58109b82017f4bbe7
Autor:
Xing Wang, Natasha Raman, Ghali Lemtiri-Chlieh, Jinhee Chang, Shreya Jagtap, Dipanwita Dutta Chowdhury, Matthew Ballew, Francesca Anna Carrieri, Triet Nguyen, Katriana Nugent, Travis Peck, Michelle S. Levine, Aaron Chan, Christine Lam, Reem Malek, Tung Hoang, Ryan Phillips, ZhuoAn Cheng, Kekoa Taparra, Nick Connis, Christine L. Hann, Andrew Holland, Phuoc T. Tran, Audrey Lafargue, Hailun Wang
Publikováno v:
Molecular Cancer Therapeutics. 22:519-528
Extra copies of centrosomes are frequently observed in cancer cells. To survive and proliferate, cancer cells have developed strategies to cluster extra-centrosomes to form bipolar mitotic spindles. The aim of this study was to investigate whether ce
Autor:
Noushin Niknafs, Archana Balan, Christopher Cherry, Karlijn Hummelink, Kim Monkhorst, Xiaoshan M. Shao, Zineb Belcaid, Kristen A. Marrone, Joseph Murray, Kellie N. Smith, Benjamin Levy, Josephine Feliciano, Christine L. Hann, Vincent Lam, Drew M. Pardoll, Rachel Karchin, Tanguy Y. Seiwert, Julie R. Brahmer, Patrick M. Forde, Victor E. Velculescu, Valsamo Anagnostou
Publikováno v:
Nature Medicine. 29:440-449
Tumor mutation burden is an imperfect proxy of tumor foreignness and has therefore failed to consistently demonstrate clinical utility in predicting responses in the context of immunotherapy. We evaluated mutations in regions of the genome that are u