Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Christine L E Siezen"'
1
The pre- and post-authorisation data published by the European Medicines Agency on the use of Biologics during pregnancy and lactation
Autor: Christine L E Siezen, N Ghalandari, J M W Hazes, J W van der Laan, E P van Puijenbroek, Radboud J E M Dolhain, H J M J Crijns, C J van der Woude
Publikováno v: British Journal of Clinical Pharmacology, 86, 580-590. Wiley-Blackwell Publishing Ltd
British Journal of Clinical Pharmacology
British Journal of Clinical Pharmacology, 86(3), 580-590. Wiley
Aims: The effects of biologics on reproduction/lactation are mostly unknown although many patients that receive biologics are women of reproductive age. The first objective of this study was to investigate the publicly available data on pregnancy/lac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5dd5a00756ba9e47f79d108d6211f77
https://hdl.handle.net/11370/63f314a7-f23b-49ad-801a-059c93e47cfc
Zobrazit plný text záznamu
3
Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: An opposite effect in boys and girls
Autor: Tjeerd G. Kimman, Christine L. E. Siezen, Louis Bont, Hans C. van Houwelingen, Jan L. L. Kimpen, Annemieke Schuurhof, Riny Janssen, Hennie M. Hodemaekers, Barbara Hoebee
Publikováno v: Pediatric Pulmonology. 45:608-613
The predominance of severe respiratory syncytial virus (RSV) bronchiolitis in boys compared to girls is well known, but its mechanism is not yet understood. This is the first study focusing on gender-specific genetic factors affecting the risk of sev
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::efa79fa816d1df88813d12d1cdfafa58
https://doi.org/10.1002/ppul.21229
Zobrazit plný text záznamu
4
Genetic variations in regulatory pathways of fatty acid and glucose metabolism are associated with obesity phenotypes: a population-based cohort study
Autor: Edith J. M. Feskens, Christine L. E. Siezen, Cisca Wijmenga, S. W. van den Berg, Jolanda M. A. Boer, W.M.M. Verschuren, B. Hoebee, Sandra Imholz, Martijn E.T. Dollé, C. Strien, R. van 't Slot
Publikováno v: International Journal of Obesity 33 (2009) 10
International Journal of Obesity, 33(10), 1143-1152
International Journal of Obesity, 33(10), 1143-1152. Nature Publishing Group
Background: As nuclear receptors and transcription factors have an important regulatory function in adipocyte differentiation and fat storage, genetic variation in these key regulators and downstream pathways may be involved in the onset of obesity.O
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69af005ae822944d374a49b88555c473
https://doi.org/10.1038/ijo.2009.152
Zobrazit plný text záznamu
5
Alternative signaling network activation through different insulin receptor family members caused by pro-mitogenic antidiabetic insulin analogues in human mammary epithelial cells
Autor: Christine L E Siezen, Bas ter Braak, Bob van de Water, Steven Wink, Esmee Koedoot, Jan Willem van der Laan, Chantal Pont
Publikováno v: Breast cancer research
Breast cancer research, 17, 97. BioMed Central
Breast Cancer Research : BCR
Introduction Insulin analogues are designed to have improved pharmacokinetic parameters compared to regular human insulin. This provides a sustained control of blood glucose levels in diabetic patients. All novel insulin analogues are tested for thei
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ca27b1a8202ab95802a48660d21201
https://doi.org/10.1186/s13058-015-0600-5
Zobrazit plný text záznamu
6
Mammary gland tumor promotion by chronic administration of IGF1 and the insulin analogue AspB10 in the p53(R270H/+)WAPCre mouse model
Autor: Esmee Koedoot, Bob van de Water, Harry van Steeg, Christine L E Siezen, Ewoud N Speksnijder, Jan Willem van der Laan, Daniela C.F. Salvatori, Bas ter Braak
Publikováno v: Breast cancer research, 17, 14
Breast Cancer Research : BCR
Breast cancer research
Introduction Insulin analogues are structurally modified molecules with altered pharmaco-kinetic and -dynamic properties compared to regular human insulin used by diabetic patients. While these compounds are tested for undesired mitogenic effects, an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a44ef2a76d9f269f14bad03f9ac274
https://doi.org/10.1186/s13058-015-0518-y
Zobrazit plný text záznamu
7
Classifying the adverse mitogenic mode of action of insulin analogues using a novel mechanism-based genetically engineered human breast cancer cell panel
Autor: Esmee Koedoot, J. W. van der Laan, Nynke M. Kannegieter, B. van de Water, B. ter Braak, Christine L E Siezen
Publikováno v: Archives of toxicology. 88(4)
Insulin analogues are widely used in clinical practice. Modifications on the insulin molecular structure can affect the affinity and activation towards two closely related receptor tyrosine kinases: the insulin receptor (INSR) and the insulin-like gr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::086114d0a46934267c78096371c5d573
https://pubmed.ncbi.nlm.nih.gov/24464500
Zobrazit plný text záznamu
8
GENETIC SUSCEPTIBILITY TO RESPIRATORY SYNCYTIAL VIRUS BRONCHIOLITIS IN PRETERM CHILDREN IS ASSOCIATED WITH AIRWAY REMODELING GENES AND INNATE IMMUNE GENES
Autor: Jan L. L. Kimpen, Tjeerd G. Kimman, Barbara Hoebee, Riny Janssen, Ciska Wijmenga, Hennie M. Hodemaekers, Marieke J. Ermers, Hans C. van Houwelingen, Gerda Doornbos, Ruben vanʼt Slot, Louis Bont, Christine L. E. Siezen
Publikováno v: Pediatric infectious disease journal, 28(4), 333-335. LIPPINCOTT WILLIAMS & WILKINS
The Pediatric Infectious Disease Journal 28 (2009) 4
The Pediatric Infectious Disease Journal, 28(4), 333-335
Prematurity is a risk factor for severe respiratory syncytial virus bronchiolitis. We show that genetic factors in innate immune genes (IFNA13, IFNAR2, STAT2. IL27, NFKBIA, C3, IL1RN, TLR5), in innate and adaptive immunity (IFNG), and in airway remod
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84da128b9ab986090a895af2607e9418
https://doi.org/10.1097/INF.0b013e31818e2aa9
Zobrazit plný text záznamu
9
Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls
Autor: Annemieke, Schuurhof, Louis, Bont, Christine L E, Siezen, Hennie, Hodemaekers, Hans C, van Houwelingen, Tjeerd G, Kimman, Barbara, Hoebee, Jan L L, Kimpen, Riny, Janssen
Publikováno v: Pediatric pulmonology. 45(6)
The predominance of severe respiratory syncytial virus (RSV) bronchiolitis in boys compared to girls is well known, but its mechanism is not yet understood. This is the first study focusing on gender-specific genetic factors affecting the risk of sev
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::98957cabd7f4e51209846b042298e862
https://pubmed.ncbi.nlm.nih.gov/20503287
Zobrazit plný text záznamu
10
Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production
Autor: Pooja Rao, Christine L E Siezen, Eytan Ruppin, Bas ter Braak, Bob van de Water, Joo Sang Lee, Jan Willem van der Laan, Charlotte Voorhoeve
Publikováno v: Breast Cancer Research : BCR
Breast cancer research, 19, 14
Breast cancer research
Background The insulin-like growth factor 1 (IGF1) signaling axis plays a major role in tumorigenesis. In a previous experiment, we chronically treated mice with several agonists of the IGF1 receptor (IGF1R). We found that chronic treatment with insu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a63347b9edebd11e7531f3511a8eda25
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje