Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Christine Keiper"'
Autor:
Jeffrey Shapiro, Bullock William H, Christine Keiper, Manami Tsutsumi, Ling Yang, Roger B Clark, Xin Ma, Sidney X. Liang, James N. Livingston, Louis-David Cantin, Christiana Iwuagwu, Frederick Ehrgott, Jeffrey Johnson, Thomas H. Claus, Ken Boakye, Herbert Ogutu, Christopher Town, Michael Burns, Michelle Daly, Robert Schoenleber, Fernando E. delaCruz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:1056-1061
Modulation of PPAR activities represents an attractive approach for the treatment of diabetes with associated cardiovascular complications. The indanylacetic acid structural motif has proven useful in the generation of potent and tunable PPAR ligands
Specific Inhibition of Hormone-Sensitive Lipase Improves Lipid Profile while Reducing Plasma Glucose
Autor:
Yin Liang, Christine Keiper Lubeski, Lynn Lemoine, Jian Zhu, Kevin B. Clairmont, Thomas H. Claus, Ling Yang, Arthur I. Salhanick, Derek B. Lowe
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 315:1396-1402
Elevation of plasma free fatty acids has been linked with insulin resistance and diabetes. Inhibition of lipolysis may provide a mechanism to decrease plasma fatty acids, thereby improving insulin sensitivity. Hormone-sensitive lipase (HSL) is a crit
Autor:
Louis-David, Cantin, Sidney, Liang, Herbert, Ogutu, Christiana I, Iwuagwu, Ken, Boakye, William H, Bullock, Michael, Burns, Roger, Clark, Thomas, Claus, Fernando E, delaCruz, Michelle, Daly, Frederick J, Ehrgott, Jeffrey S, Johnson, Christine, Keiper, James N, Livingston, Robert W, Schoenleber, Jeffrey, Shapiro, Christopher, Town, Ling, Yang, Manami, Tsutsumi, Xin, Ma
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(4)
Modulation of PPAR activities represents an attractive approach for the treatment of diabetes with associated cardiovascular complications. The indanylacetic acid structural motif has proven useful in the generation of potent and tunable PPAR ligands
Autor:
Arthur I. Salhanick, Mary E. Bowling, Terri Witman-Jones, Wai C. Wong, Christine Keiper, Furahi Achebe, Ning Qi, Kevin B. Clairmont, Steven Magnuson, Bullock William H, Derek B. Lowe, Ann-Marie Campbell, Zhenqiu Hong, Harold Kluender, Ming Wang, James H. Cook, Mareli Rodriguez
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(12)
A series of (5-(2H)-isoxazolonyl) ureas were developed as nanomolar inhibitors of hormone-sensitive lipase, an enzyme of potential importance in the treatment of diabetes.
Autor:
Claus, Thomas H, Lowe, Derek B, Liang, Yin, Salhanick, Arthur I, Lubeski, Christine Keiper, Yang, Ling, Lemoine, Lynn, Zhu, Jian, Clairmont, Kevin B
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics; December 2005, Vol. 315 Issue: 3 p1396-1402, 7p