Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Christine K. Schmidt"'
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Microbot delivery devices are the latest development in attempts to overcome the systemic toxicity associated with classical chemotherapy. Here, the authors review the recent progress in the field with a focus on the clinical translation and potentia
Externí odkaz:
https://doaj.org/article/b32cc2158a1a44d9b1642c1b78f57099
Publikováno v:
Biomolecules, Vol 10, Iss 11, p 1557 (2020)
Maintenance of genome stability is a crucial priority for any organism. To meet this priority, robust signalling networks exist to facilitate error-free DNA replication and repair. These signalling cascades are subject to various regulatory post-tran
Externí odkaz:
https://doaj.org/article/68fd399dd4264492b6db3789bab6a0d5
Autor:
Charlotte J Heaven, Hannah C Wanstall, Nicholas T Henthorn, John-William Warmenhoven, Samuel P Ingram, Amy L Chadwick, Elham Santina, Jamie Honeychurch, Christine K Schmidt, Karen J Kirkby, Norman F Kirkby, Neil G Burnet, Michael J Merchant
Publikováno v:
Heaven, C J, Wanstall, H C, Henthorn, N T, Warmenhoven, J-W, Ingram, S P, Chadwick, A L, Santina, E, Honeychurch, J, Schmidt, C K, Kirkby, K J, Kirkby, N F, Burnet, N G & Merchant, M J 2022, ' The suitability of micronuclei as markers of relative biological effect ', Mutagenesis, vol. 37, no. 1, pp. 3-12 . https://doi.org/10.1093/mutage/geac001
Mutagenesis
Mutagenesis
Micronucleus (MN) formation is routinely used as a biodosimeter for radiation exposures and has historically been used as a measure of DNA damage in cells. Strongly correlating with dose, MN are also suggested to indicate radiation quality, different
Publikováno v:
Trends in Cell Biology. 31:628-643
Ubiquitin and ubiquitin-like proteins (UBLs) function as critical post-translational modifiers in the maintenance of genome stability. Ubiquitin/UBL-conjugating enzymes (E2s) are responsible, as part of a wider enzymatic cascade, for transferring sin
Publikováno v:
Biomolecular Nmr Assignments
DNA double-strand breaks (DSBs) represent the most cytotoxic DNA lesions, as—if mis- or unrepaired—they can cause cell death or lead to genome instability, which in turn can cause cancer. DSBs are repaired by two major pathways termed homologous
Autor:
Haifeng Xu, Wunan Zhang, Carla Ribeiro, Mariana Medina-Sánchez, Lina P. Restrepo, Richard J. Edmondson, Oliver G. Schmidt, Christine K. Schmidt, Melanie Patricia Hannah Seaton, Steven Bagley, Louisa Nelson, Daniel R Brison, Elkin Lucena, Kang Zeng, Stephen S. Taylor
Publikováno v:
Xu, H, Medina-sánchez, M, Zhang, W, Seaton, M P H, Brison, D R, Edmondson, R, Taylor, S S, Nelson, L, Zeng, K, Bagley, S, Ribeiro, C, Restrepo, L P, Lucena, E, Schmidt, C K & Schmidt, O G 2020, ' Human spermbots for patient-representative 3D ovarian cancer cell treatment ', Nanoscale . https://doi.org/10.1039/D0NR04488A
Nanoscale
Nanoscale
Cellular micromotors are attractive for locally delivering high concentrations of drug, and targeting hard-to-reach disease sites such as cervical cancer and early ovarian cancer lesions by non-invasive means. Spermatozoa are highly efficient micromo
Autor:
Christine K. Schmidt, María J. Cabello-Lobato, Stephen P. Jackson, Matthew J. Cliff, Matthew Jenner, Qian Wu, Christian M. Loch
SUMOylation is critical for a plethora of cellular signalling pathways including the repair of DNA double-strand breaks (DSBs). If misrepaired, DSBs can lead to cancer, neurodegeneration, immunodeficiency and premature ageing. Based on systematic pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::242da52e9e8d256f364e7ed1ae3f2093
https://doi.org/10.1101/2021.01.20.427433
https://doi.org/10.1101/2021.01.20.427433
Publikováno v:
Sandy, Z, Da Costa, I C & Schmidt, C K 2020, ' More than meets the ISG15: emerging roles in the DNA damage response and beyond ', Biomolecules . https://doi.org/10.3390/biom10111557
Biomolecules
Biomolecules, Vol 10, Iss 1557, p 1557 (2020)
Biomolecules
Biomolecules, Vol 10, Iss 1557, p 1557 (2020)
Maintenance of genome stability is a crucial priority for any organism. To meet this priority, robust signalling networks exist to facilitate error-free DNA replication and repair. These signalling cascades are subject to various regulatory post-tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e92dd45b32939fa0c37a5c6a738223
https://pure.manchester.ac.uk/ws/files/185514303/biomolecules_10_01557.pdf
https://pure.manchester.ac.uk/ws/files/185514303/biomolecules_10_01557.pdf
Publikováno v:
Osborne, H C, Durie, A, Schmidt, C K & Larrosa, I 2020, ' C–H Borylation: No Need to Stop for Directions ', Trends in Chemistry . https://doi.org/10.1016/j.trechm.2020.07.009
A recent work by Hartwig et al. (Science, 2020) details an efficient method to borylate strong primary C(sp3)–H bonds via iridium-catalysed C–H activation. The conditions confer counterintuitive selectivity over more labile C–H bonds, while pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba2fb1dfcf097e490eaa52a7fc2ad25
https://pure.manchester.ac.uk/ws/files/175585798/Trends_Spotlight_Titles.pdf
https://pure.manchester.ac.uk/ws/files/175585798/Trends_Spotlight_Titles.pdf
Publikováno v:
Trends in molecular medicine. 26(12)