Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Christine K. Maurer"'
Autor:
Giuseppe Allegretta, Christine K. Maurer, Jens Eberhard, Damien Maura, Rolf W. Hartmann, Laurence Rahme, Martin Empting
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
Pseudomonas aeruginosa is a Gram-negative bacterium, which causes opportunistic infections in immuno-compromised individuals. Due to its multiple resistances toward antibiotics, the development of new drugs is required. Interfering with Quorum Sensin
Externí odkaz:
https://doaj.org/article/9c7fffecdf724a0497e57d75b984355f
Autor:
Giuseppe Allegretta, Christine K. Maurer, Jens Eberhard, Damien Maura, Rolf W. Hartmann, Laurence Rahme, Martin Empting
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
Pseudomonas aeruginosa is a Gram-negative bacterium, which causes opportunistic infections in immuno-compromised individuals. Due to its multiple resistances toward antibiotics, the development of new drugs is required. Interfering with Quorum Sensin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::889c055998baaafeddfda59200ee919a
Autor:
Ningna Xu, Wulf Blankenfeldt, Andreas M. Kany, Martin Empting, Carsten Börger, Benjamin Kirsch, Michael Zender, Alexander Kiefer, Florian Witzgall, Stefan Schmelz, Christine K. Maurer
Publikováno v:
Chemmedchem
ChemMedChem
ChemMedChem
Hit‐to‐lead optimization is a critical phase in drug discovery. Herein, we report on the fragment‐based discovery and optimization of 2‐aminopyridine derivatives as a novel lead‐like structure for the treatment of the dangerous opportunisti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ccd8e32bc9ff84e8ccb59341424d39
http://europepmc.org/articles/PMC7004148
http://europepmc.org/articles/PMC7004148
Autor:
Konrad Viehrig, Alberto Plaza, Shwan Rachid, Rolf Müller, Christine K. Maurer, Rolf W. Hartmann, Frank Surup
Publikováno v:
ACS Chemical Biology. 13:267-272
Analysis of the genome sequence of the myxobacterium Chondromyces crocatus Cm c5 revealed the presence of numerous cryptic megasynthetase gene clusters, one of which we here assign to two previously unknown chlorinated metabolites by a comparative ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63bc2fae55aed92370757f8c9fb70aea
https://doi.org/10.1021/acschembio.7b00900
https://doi.org/10.1021/acschembio.7b00900
Autor:
Jennifer Herrmann, Christine K. Maurer, Olga Avrutina, Rolf W. Hartmann, Martin Empting, Petra Dersch, Jan Gorges, Martina Fruth, Suvd Nadmid, Rolf Müller, Uli Kazmaier, Jörn Hoßmann
Publikováno v:
Future Medicinal Chemistry. 8:931-947
Aim: CsrA is a global post-transcriptional regulator protein affecting mRNA translation and/or stability. Widespread among bacteria, it is essential for their full virulence and thus represents a promising anti-infective drug target. Therefore, we ai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a30e097d4fed351b12c5f57067c1693
https://doi.org/10.4155/fmc-2016-0033
https://doi.org/10.4155/fmc-2016-0033
Autor:
Steffen L. Drees, Martin Empting, Florian Witzgall, Wulf Blankenfeldt, Elisabeth Weidel, Susanne Fetzner, Christine K. Maurer, Rolf W. Hartmann, Michael Zender
Publikováno v:
ACS Chemical Biology. 11:1755-1763
Pseudomonas aeruginosa uses quorum sensing (QS) as a cell-to-cell communication system to orchestrate the expression of virulence determinants. The biosynthesis of the important Pseudomonas quinolone signal (PQS) requires the pqsABCDE operon. Here, P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d7b5f5d82c7e2e22f7f7b228756c34c
https://doi.org/10.1021/acschembio.6b00156
https://doi.org/10.1021/acschembio.6b00156
Autor:
Florian Witzgall, Christine K. Maurer, Stefan Schmelz, Carsten Börger, Benjamin Kirsch, Ningna Xu, Wulf Blankenfeldt, Martin Empting, Andreas M. Kany, Michael Zender, Alexander Kiefer
Publikováno v:
ChemMedChem. 15:176-176
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88aadf0c566bfbdd51847e835cbbc6c2
https://doi.org/10.1002/cmdc.201900684
https://doi.org/10.1002/cmdc.201900684
Autor:
Andreas M. Kany, Samir Yahiaoui, Ewgenij Proschak, Christine K. Maurer, Asfandyar Sikandar, Rolf W. Hartmann, Jörg Haupenthal, Jesko Köhnke
Publikováno v:
ACS infectious diseases. 4(6)
The increasing emergence of antibiotic resistance necessitates the development of anti-infectives with novel modes of action. Targeting bacterial virulence is considered a promising approach to develop novel antibiotics with reduced selection pressur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04350cb68fc54e9c902368628c3e1110
https://pubmed.ncbi.nlm.nih.gov/29485268
https://pubmed.ncbi.nlm.nih.gov/29485268
Autor:
Ahmed A. M. Kamal, Christine K. Maurer, Martin Empting, Giuseppe Allegretta, Rolf W. Hartmann, Jörg Haupenthal
Publikováno v:
Topics in Medicinal Chemistry ISBN: 9783319708386
Decades after the Golden Age of antibiotics, it is evident that antibiotic resistance is rapidly evolving and spreading among clinically relevant pathogens. The medical need for alternative anti-infective treatments is tremendously high today. A nove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fdd34f2a611cb3ed7170a4b5f4c1720
https://doi.org/10.1007/7355_2017_17
https://doi.org/10.1007/7355_2017_17
Autor:
Christine K. Maurer, Anke Steinbach, Rolf W. Hartmann, Chiara De Rossi, Marc Schneider, Claus-Michael Lehr, Ayman Husari, Noha Nafee, Cenbin Lu
Publikováno v:
Journal of Controlled Release. 192:131-140
Cystic fibrosis (CF) is a genetic disease mainly manifested in the respiratory tract. Pseudomonas aeruginosa (P. aeruginosa) is the most common pathogen identified in cultures of the CF airways, however, its eradication with antibiotics remains chall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edf3a8d138545fd24e31979e7ddecbfb
https://doi.org/10.1016/j.jconrel.2014.06.055
https://doi.org/10.1016/j.jconrel.2014.06.055