Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Christine K. Jordan"'
Autor:
Fiona Clarke, Christine K Jordan, Enrique Gutiérrez-Martinez, Jack A Bibby, Cristina Sanchez-Blanco, Georgina H Cornish, Xuezhi Dai, David J Rawlings, Rose Zamoyska, Pierre Guermonprez, Andrew P Cope, Harriet A Purvis
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186625 (2017)
The PTPN22R620W single nucleotide polymorphism increases the risk of developing multiple autoimmune diseases including type 1 diabetes, rheumatoid arthritis and lupus. PTPN22 is highly expressed in antigen presenting cells (APCs) where the expression
Externí odkaz:
https://doaj.org/article/fa86f2a42392422eaf03f48c18aab3f6
OP0296 Autoimmune associated gene PTPN22 negatively regulates DECTIN-1 signalling in dendritic cells
Autor:
Andrew P. Cope, Georgina H. Cornish, Rose Zamoyska, Fiona Clarke, David J. Rawlings, Cristina Sanchez-Blanco, Harriet A. Purvis, Christine K. Jordan
Publikováno v:
Oral Presentations.
Background A single nucleotide polymorphism within the phosphatase PTPN22 increases the risk of developing multiple autoimmune and connective tissue diseases.1 Ptpn22 is a negative regulator of Syk and Src family kinases downstream of immuno-receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3f1a097b3d084630542a4f68348a8f7
https://doi.org/10.1136/annrheumdis-2017-eular.4717
https://doi.org/10.1136/annrheumdis-2017-eular.4717
Autor:
Clare A. Notley, Christine K. Jordan, Jenny L. McGovern, Mark A. Brown, Michael R. Ehrenstein
Publikováno v:
Scientific Reports
Efficient clearance of apoptotic cells (AC) is pivotal in preventing autoimmunity and is a potent immunosuppressive stimulus. However, activation of cells prior to apoptosis abolishes their immunoregulatory properties. Here we show using the antigen-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::73da5a826bb31d389ac52b258d9a0727
http://europepmc.org/articles/PMC5294421
http://europepmc.org/articles/PMC5294421
Autor:
Clare A, Notley, Mark A, Brown, Jenny L, McGovern, Christine K, Jordan, Michael R, Ehrenstein
Publikováno v:
The Journal of Immunology Author Choice
Phagocytosis of apoptotic cells (ACs) is usually a potent immunoregulatory signal but can also promote inflammation. In this article, we show that administration of apoptotic dendritic cells (DCs) inhibited inflammation in vivo through increasing pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5c9e892bf64d1f772b7d15e7d51e1de6
https://pubmed.ncbi.nlm.nih.gov/25601923
https://pubmed.ncbi.nlm.nih.gov/25601923