Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Christine K Mauck"'
Autor:
Christine K Mauck, George J Atiee, Jennifer McCulloh, Laurie Reynolds, Nadene Zack, David R Friend
Publikováno v:
Journal of Antimicrobial Chemotherapy. 78:257-262
Objectives To evaluate pharmacokinetics (PK) of a single dose of an investigational 2% clindamycin phosphate vaginal gel in healthy women by assessment of plasma and vaginal clindamycin concentrations over 7 days, and assess safety. Methods Single-ce
Autor:
Jeffrey T. Jensen, Kurt T. Barnhart, Breione J. St. Claire, Terri L. Walsh, Anita L. Nelson, Jill L. Schwartz, Livia Wan, Christine K. Mauck, David F. Archer, Margaret C. Snead, Diana L. Blithe, Mark A. Weaver, Ron G. Frezieres, Michael A. Thomas
Publikováno v:
Contraception
Objective To investigate whether rates of self-reported Woman's Condom (WC) clinical failure and semen exposure from a functionality study are comparable to results from a contraceptive efficacy substudy. Study design We structured our comparative an
Autor:
Susana N. Asin, Gustavo F. Doncel, Jill L. Schwartz, Christiane Rollenhagen, Christine K. Mauck, Sharon L. Hillier, Vivian Brache, Neelima Chandra, Raina N. Fichorova, Debra H. Weiner, Betsy C. Herold, Andrea R. Thurman, Beatrice A. Chen
Publikováno v:
AIDS Research and Human Retroviruses. 35:853-864
Reproductive age women may choose to concurrently use topical antiretrovirals and hormonal contraceptives (HCs) to simultaneously prevent HIV-1 infection and unintended/mistimed pregnancy. There are conflicting data on the effect of HCs on mucosal su
Autor:
Jill L. Schwartz, Andrea R. Thurman, Gustavo F. Doncel, Debra H. Weiner, Angela D. M. Kashuba, Neelima Chandra, Vivian Brache, Beatrice A. Chen, Christine K. Mauck
Publikováno v:
JAIDS Journal of Acquired Immune Deficiency Syndromes. 80:79-88
Endogenous and exogenous contraceptive hormones may affect mucosal pharmacokinetics (PKs) of topical antiretrovirals such as tenofovir. We present PK data from healthy women using tenofovir vaginal gel, at baseline (follicular and luteal phases) and
Autor:
Jacques Ravel, Pawel Gajer, Li Fu, Christine K. Mauck, Sara S. K. Koenig, Joyce Sakamoto, Alison A. Motsinger-Reif, Gustavo F. Doncel, Steven L. Zeichner
Publikováno v:
mBio, Vol 3, Iss 6 (2012)
ABSTRACT Vaginal HIV microbicides offer great promise in preventing HIV transmission, but failures of phase 3 clinical trials, in which microbicide-treated subjects had an increased risk of HIV transmission, raised concerns about endpoints used to ev
Externí odkaz:
https://doaj.org/article/a7718b81e5254717a9f4623129494649
Autor:
Christine K Mauck, Kathleen L. Vincent
Publikováno v:
Biology of Reproduction
Postcoital tests (PCTs) have been used for over a century in the clinical evaluation of infertile couples, and for nearly 70 years in the evaluation of new vaginal contraceptive products. PCTs have been largely replaced by more modern methods in the
Autor:
Gustavo F. Doncel, Nazita Yousefieh, Andrea R. Thurman, Jill L. Schwartz, Sharon Anderson, Neelima Chandra, Xi Fang, Oluwatosin E. Adedipe, Suzanne S. Jackson, Christine K. Mauck, Irina A. Zalenskaya
Publikováno v:
Journal of Clinical Investigation. 128:4622-4638
BACKGROUND. Injectable depot medroxyprogesterone acetate (DMPA) is one of the most popular contraception methods in areas of high HIV seroprevalence. Evidence is accumulating that use of DMPA might be associated with an increased risk of HIV-1 acquis
Autor:
David F. Archer, Margaret C. Snead, Terry A. Jacot, R. Jamshidi, Thomas Kimble, Andrea R. Thurman, Christine K. Mauck, Angie Wheeless, Johan H. Melendez, Gustavo F. Doncel
Publikováno v:
Contraception. 94:512-520
The primary objective of this pilot study is to determine and compare the residence time in the vagina of biomarkers of semen exposure for up to 15 days post exposure. The biomarkers are prostate-specific antigen (PSA), Y chromosome DNA, the sex dete
Autor:
Kathleen L. Vincent, Christine K Mauck
Publikováno v:
Biology of Reproduction
Postcoital tests (PCTs) have been used for over a century in the clinical evaluation of infertile couples, and for nearly 70 years in the evaluation of new vaginal contraceptive products. PCTs have been largely replaced by more modern methods in the
Autor:
Lynn Bradley, David F. Archer, Jill L. Schwartz, Kurt T. Barnhart, Ron G. Frezieres, Christine K. Mauck, Debra H. Weiner, Maggie Kilbourne-Brook, Alfred N. Poindexter, Jaim Jou Lai, Mitchell D. Creinin, Marianne M. Callahan
Publikováno v:
Obstetrics & Gynecology. 125:895-903
OBJECTIVE:: To estimate contraceptive efficacy safety acceptability and fit of a single-size diaphragm used with contraceptive gel. METHODS:: We conducted a multicenter trial in which 450 couples used the single-size diaphragm 300 randomized to acid-