Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Christine Josenhans"'
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-22 (2024)
Abstract Background Bacterial epigenetics is a rapidly expanding research field. DNA methylation by diverse bacterial methyltransferases (MTases) contributes to genomic integrity and replication, and many recent studies extended MTase function also t
Externí odkaz:
https://doaj.org/article/9f196c903e5a437b9505e565c111ec38
Autor:
Diego García-Weber, Anne-Sophie Dangeard, Veronica Teixeira, Martina Hauke, Alexis Carreaux, Christine Josenhans, Cécile Arrieumerlou
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Alpha-protein kinase 1 (ALPK1) is a pathogen recognition receptor that detects ADP-heptose (ADPH), a lipopolysaccharide biosynthesis intermediate, recently described as a pathogen-associated molecular pattern in Gram-negative bacteria. ADPH
Externí odkaz:
https://doaj.org/article/434deacb5e94426db8c6d6142e4b9424
Publikováno v:
International Journal of Medical Microbiology, Vol 313, Iss 4, Pp 151585- (2023)
Lipopolysaccharide inner core heptose metabolites, including ADP-heptose, play a substantial role in the activation of cell-autonomous innate immune responses in eukaryotic cells, via the ALPK1-TIFA signaling pathway, as demonstrated for various path
Externí odkaz:
https://doaj.org/article/8b8ca4b699b2432289317768dd0dbb28
Autor:
Martina Hauke, Felix Metz, Johanna Rapp, Larissa Faass, Simon H. Bats, Sandra Radziej, Hannes Link, Wolfgang Eisenreich, Christine Josenhans
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT Heptose metabolites including ADP-d-glycero-β-d-manno-heptose (ADP-heptose) are involved in bacterial lipopolysaccharide and cell envelope biosynthesis. Recently, heptoses were also identified to have potent proinflammatory activity on huma
Externí odkaz:
https://doaj.org/article/6bfe2c934cc848208d93214055eee2fb
Publikováno v:
PLoS Pathogens, Vol 19, Iss 4, p e1011306 (2023)
As a facultative intracellular pathogen, Salmonella enterica serovar Typhimurium is one of the leading causes of food-borne diseases in humans. With the ingestion of fecal contaminated food or water, S. Typhimurium reaches the intestine. Here, the pa
Externí odkaz:
https://doaj.org/article/0aff72cfa79744fda3aba7cc9b0b345c
Autor:
Sebastian Suerbaum, Nina Coombs, Lubna Patel, Dimitri Pscheniza, Katharina Rox, Christine Falk, Achim D. Gruber, Olivia Kershaw, Patrick Chhatwal, Mark Brönstrup, Ursula Bilitewski, Christine Josenhans
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
Externí odkaz:
https://doaj.org/article/e76f3508d5c14d18a67d2816e6e1fe80
Autor:
Sebastian Suerbaum, Nina Coombs, Lubna Patel, Dimitri Pscheniza, Katharina Rox, Christine Falk, Achim D. Gruber, Olivia Kershaw, Patrick Chhatwal, Mark Brönstrup, Ursula Bilitewski, Christine Josenhans
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT New treatment options against the widespread cancerogenic gastric pathogen Helicobacter pylori are urgently needed. We describe a novel screening procedure for inhibitors of H. pylori flagellar biosynthesis. The assay is based on a flaA flag
Externí odkaz:
https://doaj.org/article/23a756c0b8254db1bc9461c34a8acd08
Autor:
Zeli Shen, JoAnn Dzink-Fox, Yan Feng, Sureshkumar Muthupalani, Anthony J. Mannion, Alexander Sheh, Mark T. Whary, Hilda R. Holcombe, Blanca M. Piazuelo, Luis E. Bravo, Christine Josenhans, Sebastian Suerbaum, Keith T. Wilson, Richard M. Peek, Timothy C. Wang, James G. Fox
Publikováno v:
mSphere, Vol 7, Iss 1 (2022)
ABSTRACT In populations with similar prevalence of Helicobacter pylori infection, cancer risk can vary dramatically. Changes in composition or structure of bacterial communities in the stomach, either at the time of exposure or over the course of H.
Externí odkaz:
https://doaj.org/article/9e55ff19818544809735685cec27b446
Autor:
Larissa Faass, Saskia C. Stein, Martina Hauke, Madeleine Gapp, Manuel Albanese, Christine Josenhans
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The human gastric pathogen Helicobacter pylori activates human epithelial cells by a particular combination of mechanisms, including NOD1 and ALPK1-TIFA activation. These mechanisms are characterized by a strong participation of the bacterial cag pat
Externí odkaz:
https://doaj.org/article/ca6309487e974da2bd590bd42ce840fe
Autor:
Saskia Schmitt, Siret Tahk, Alina Lohner, Gerulf Hänel, Andreas Maiser, Martina Hauke, Lubna Patel, Maurine Rothe, Christine Josenhans, Heinrich Leonhardt, Marieke Griffioen, Katrin Deiser, Nadja C. Fenn, Karl-Peter Hopfner, Marion Subklewe
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Conventional dendritic cell (DC) vaccine strategies, in which DCs are loaded with antigens ex vivo, suffer biological issues such as impaired DC migration capacity and laborious GMP production procedures. In a promising alternative, antigens are targ
Externí odkaz:
https://doaj.org/article/e082309ebca1404a9c1701d0a15f7f62