Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Christine J. Rossant"'
Autor:
Danielle Carroll, John Elvin, Simon T. Barry, Christine J. Rossant, Joris J. Benschop, Eldar E Kim, Frances Neal, Ling Huang, Edward H. Walker, Tristan J. Vaughan
Publikováno v:
mAbs. 6:1425-1438
Generation of functional antibodies against integral membrane proteins such as the G-protein coupled receptor CXCR2 is technically challenging for several reasons, including limited epitope accessibility, the requirement for a lipid environment to ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eadd41c44080ce3b82ae4fa01b304bd
https://doi.org/10.4161/mabs.34376
https://doi.org/10.4161/mabs.34376
Autor:
Ralph Minter, Evert Bokma, Desmond J. O'Shea, Lutz Jermutus, Andrea L. Gonzalez-Munoz, Kevin Minton, Christine J. Rossant, Strain Martin D, Katherine A. Vousden
Publikováno v:
mAbs
Antibodies are a unique class of proteins with the ability to adapt their binding sites for high affinity and high specificity to a multitude of antigens. Many analyses have been performed on antibody sequences and structures to elucidate which amino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276623908cc6301a07204df56569a0a0
http://europepmc.org/articles/PMC3502233
http://europepmc.org/articles/PMC3502233
Autor:
Caroline Colley, Christine J. Rossant, Trevor Wilkinson, David Lowne, Joanne Arnold, Sadhana Podichetty, Claire Dobson, Frances Neal, Rob Howes, Tristan J. Vaughan
Publikováno v:
Journal of biomolecular screening. 21(1)
Calcitonin gene-related peptide (CGRP) is a small neuropeptide and a potent vasodilator that is widely associated with chronic pain and migraine. An antibody that inhibits CGRP function would be a potential therapeutic for treatment of these disorder
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6db2d3b87dfc70da13474714bc20559
https://pubmed.ncbi.nlm.nih.gov/26450103
https://pubmed.ncbi.nlm.nih.gov/26450103
Autor:
Turkstra Johan, Catherine Jane Marsden, Clive Graham Copley, Ronald S Boshuizen, Jerry W. Slootstra, Klaus Schwamborn, Christine J. Rossant
Publikováno v:
mAbs. 6(6)
Development of functional monoclonal antibodies against intractable GPCR targets.Identification of structured peptides mimicking the ligand binding site, their use in panning to enrich for a population of binders, and the subsequent challenge of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e6f80c57c02fbfc776aa697c7db44d
https://pubmed.ncbi.nlm.nih.gov/25484047
https://pubmed.ncbi.nlm.nih.gov/25484047
Autor:
Caroline Colley, Tristan J. Vaughan, Christine J. Rossant, Carl Anthony Matthews, Frances Neal, Matthew J. Gardener
Publikováno v:
Journal of biomolecular screening. 20(4)
Identification of potential lead antibodies in the drug discovery process requires the use of assays that not only measure binding of the antibody to the target molecule but assess a wide range of other characteristics. These include affinity ranking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d4da2fa8760ba348a3d59e5c2530291
https://pubmed.ncbi.nlm.nih.gov/25381254
https://pubmed.ncbi.nlm.nih.gov/25381254
Autor:
Christine J. Rossant, Caroline Colley, Elizabeth England, Frances Neal, Lisa Kitching, Philip Newton
Publikováno v:
Journal of biomolecular screening. 20(4)
Highly sensitive, high-throughput assay technologies are required for the identification of antibody therapeutics. Multiplexed assay systems are particularly advantageous because they allow evaluation of several parameters within 1 well, increasing t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93086580b0fcd69d729d1d0c6a41f641
https://pubmed.ncbi.nlm.nih.gov/25381256
https://pubmed.ncbi.nlm.nih.gov/25381256
Publikováno v:
Journal of neurochemistry. 62(4)
All known nicotinic receptor alpha subunits include a conserved disulfide bond that is essential for function and is a site for labeling via biochemical modification. In an effort to develop a universal ligand for all subtypes of nicotinic receptors,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8565954bd0ecc8c224f5427602f346
https://pubmed.ncbi.nlm.nih.gov/8133267
https://pubmed.ncbi.nlm.nih.gov/8133267