PPARs: Protectors or Opponents of Myocardial Function?

Autor: Christine J. Pol, Melissa Lieu, Konstantinos Drosatos

Publikováno v: PPAR Research, Vol 2015 (2015)

Over 5 million people in the United States suffer from the complications of heart failure (HF), which is a rapidly expanding health complication. Disorders that contribute to HF include ischemic cardiac disease, cardiomyopathies, and hypertension. Pe

Externí odkaz: https://doaj.org/article/614a5c09e70649a68dac710eb3b1c2f2

Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21

Autor: Iordanes Karagiannides, Konstantinos Drosatos, Ira J. Goldberg, Brett R. Brown, Michael J. Jurczak, Christine J. Pol, Effimia Zacharia, Nina M. Pollak, Panagiotis Ntziachristos, Diego Scerbo, Iannis Aifantis, Ioannis D. Kyriazis, Gerald I. Shulman

Publikováno v: Biochim Biophys Acta Mol Basis Dis

Cardiac metabolism affects systemic energetic balance. Previously, we showed that Krüppel-like factor (KLF)-5 regulates cardiomyocyte PPARα and fatty acid oxidation-related gene expression in diabetes. We surprisingly found that cardiomyocyte-speci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e22264f3426d338f4c050904ae06354
https://pubmed.ncbi.nlm.nih.gov/31029826

Modified Low-Dose Triiodo-L-thyronine Therapy Safely Improves Function Following Myocardial Ischemia-Reperfusion Injury

Autor: Olga V. Savinova, Youhua Zhang, Clifford Costello, Viswanathan Rajagopalan, Ann Lehto, Yue-Feng Chen, Samantha Seitter, Christine J. Pol, A. Martin Gerdes

Publikováno v: Frontiers in Physiology

Background: We have shown that thyroid hormones (THs) are cardioprotective and can be potentially used as safe therapeutic agents for diabetic cardiomyopathy and permanent infarction. However, no reliable, clinically translatable protocol exists for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f9018700e733e77222e962a8b9dc04
http://europepmc.org/articles/PMC5388763

Abstract 301: Initial Increase of Klf5 and Ppara Expression After Myocardial Ischemia/Reperfusion in Mice Appears to be Critical for Survival

Autor: Mesele-Christina Valenti, Erhe Gao, Christine J. Pol, Konstantinos Drosatos, Ira J. Goldberg, Ancai Yuan, Sarah M. Schumacher, Walter J. Koch

Publikováno v: Circulation Research. 119

Krüppel-like factors (KLF) have important roles in metabolism. We previously found that KLF5 is a positive transcriptional regulator of peroxisome proliferator-activated receptor α ( Ppara) , a central regulator of cardiac fatty acid oxidation (FAO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba305db934baad2377918eb4609650ea
https://doi.org/10.1161/res.119.suppl_1.301

Cardiomyocyte-specific inactivation of thyroid hormone in pathologic ventricular hypertrophy: an adaptative response or part of the problem?

Autor: Warner S. Simonides, Christine J. Pol, A. Muller

Publikováno v: Heart Failure Reviews
Heart Failure Reviews, 15(2), 133-142. Springer Netherlands
Pol, C J, Muller, A & Simonides, W S 2010, ' Cardiomyocyte-specific inactivation of thyroid hormone in pathologic ventricular hypertrophy: an adaptative response or part of the problem? ', Heart Failure Reviews, vol. 15, no. 2, pp. 133-142 . https://doi.org/10.1007/s10741-008-9133-7

Recent studies in various rodent models of pathologic ventricular hypertrophy report the re-expression of deiodinase type 3 (D3) in cardiomyocytes. D3 inactivates thyroid hormone (T3) and is mainly expressed in tissues during development. The stimula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00852c18bf33eb8be7992d1d9ab0f14
https://doi.org/10.1007/s10741-008-9133-7