Výsledky vyhledávání - "Christine J. F. Nielsen"

Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases

Autor: Christine J. F. Nielsen, Kurt V. Gothelf, J. Simon C. Arthur, Erik Daa Funder, Helle Gotfred-Rasmussen, Jacob Andersen, Poul Nissen, Mads Kirchheiner Rasmussen, Borbala Gesser, Rachel Toth, Lars Iversen

Publikováno v: Andersen, J L, Gesser, B, Funder, E D, Nielsen, C J F, Gotfred-Rasmussen, H, Rasmussen, M K, Toth, R, Gothelf, K V, Arthur, J S C, Iversen, L & Nissen, P 2018, ' Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases ', Nature Communications, vol. 9, no. 1, 4344 . https://doi.org/10.1038/s41467-018-06787-w
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)

Dimethyl fumarate (DMF) has been applied for decades in the treatment of psoriasis and now also multiple sclerosis. However, the mechanism of action has remained obscure and involves high dose over long time of this small, reactive compound implicati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a8b9f1ef81620ab1ee814f6c2f8a1b
https://pure.au.dk/portal/da/publications/dimethyl-fumarate-is-an-allosteric-covalent-inhibitor-of-the-p90-ribosomal-s6-kinases(ff27ac53-9409-4678-aaee-a1e66d966606).html

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Droplet microfluidics platform for highly sensitive and quantitative detection of malaria-causing Plasmodium parasites based on enzyme activity measurement

Publikováno v: ACS Nano
ACS Nano, American Chemical Society, 2012, 6 (12), pp.10676-10683
Juul, S, Nielsen, C J F, Labouriau, R, Roy, A, Tesauro, C, Jensen, P W, Harmsen, C, Kristoffersen, E L, Chiu, Y-L, Hougaard, R F, Fiorani, P, Cox-Singh, J, Tordrup, D P, Koch, J E, Bienvenu, A-L, Desideri, A, Picot, S, Petersen, E, Leong, K W, Ho, Y-P, Stougaard, M & Knudsen, B R 2012, ' Droplet Microfluidics Platform for Highly Sensitive and Quantitative Detection of Malaria-Causing Plasmodium Parasites Based on Enzyme Activity Measurement ', A C S Nano, vol. 6, no. 12, pp. 10676-10683 . https://doi.org/10.1021/nn3038594
ACS nano 6 (2012): 10676–10683. doi:10.1021/nn3038594
info:cnr-pdr/source/autori:Juul S.; Nielsen C.J.F.; Labouriau R.; Roy A.; Tesauro C.; Jensen P.W.; Harmsen C.; Kristoffersen E.L.; Chiu Y.-L.; Frohlich R.; Fiorani P.; Cox-Singh J.; Tordrup D.; Koch J.; Bienvenu A.-L.; Desideri A.; Picot S.; Petersen E.; Leong K.W.; Ho Y.-P.; Stougaard M.; Knudsen B.R./titolo:Droplet microfluidics platform for highly sensitive and quantitative detection of malaria-causing plasmodium parasites based on enzyme activity measurement/doi:10.1021%2Fnn3038594/rivista:ACS nano/anno:2012/pagina_da:10676/pagina_a:10683/intervallo_pagine:10676–10683/volume:6

We present an attractive new system for the specific and sensitive detection of the malaria-causing Plasmodium parasites. The system relies on isothermal conversion of single DNA cleavage-ligation events catalyzed specifically by the Plasmodium enzym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c14843167531818ad0825b1fd5dec43
https://pubmed.ncbi.nlm.nih.gov/23121492

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Specific detection of topoisomerase I from the malaria causing P. falciparum parasite using isothermal rolling circle amplification

Autor: Eskild Petersen, Birgitta R. Knudsen, Barbara Arnò, Rikke Frøhlich, Felicie F. Andersen, Magnus Stougaard, Alessandro Desideri, Paola Fiorani, Christine J. F. Nielsen, Cinzia Tesauro, Sissel Juul

Publikováno v: Tesauro, C, Juul, S, Arno, B, Nielsen, C J F, Fiorani, P, Frøhlich, R F, Andersen, F F, Desideri, A, Stougaard, M, Petersen, E & Knudsen, B R 2012, ' Specific detection of topoisomerase i from the malaria causing P. falciparum parasite using isothermal Rolling Circle Amplification ', I E E E Engineering in Medicine and Biology Society. Conference Proceedings, vol. 2012, pp. 2416-2419 . https://doi.org/10.1109/EMBC.2012.6346451
EMBC

We present a Rolling-Circle-Enhance-Enzyme-Activity-Detection (REEAD) system with potential use for future point-of-care diagnosis of malaria. In the developed setup, specific detection of malaria parasites in crude blood samples is facilitated by th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad4f040d182e278619089941e6f2e8a
http://hdl.handle.net/2108/79107

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Peptide Inhibition of Topoisomerase IB from Plasmodium falciparum

Autor: Rune R. Laursen, Amit Roy, Ilda D'Annessa, Birgitta R. Knudsen, Alessandro Desideri, Christine J. F. Nielsen, Felicie F. Andersen, David Tordrup

Publikováno v: Molecular Biology International
Roy, A, D'Annessa, I, Nielsen, C J F, Tordrup, D P, Laursen, R R, Andersen, F F, Desideri, A & Knudsen, B R 2011, ' Peptide Inhibition of Topoisomerase IB from Plasmodium falciparum. ', Molecular Biology International, pp. 854626 . https://doi.org/10.4061/2011/854626

Control of diseases inflicted by protozoan parasites such asLeishmania, Trypanosoma, andPlasmodium, which pose a serious threat to human health worldwide, depends on a rather small number of antiparasite drugs, of which many are toxic and/or ineffici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4389708d29d25c1141ed0aa3d0a0eea8
http://europepmc.org/articles/PMC3200115

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