Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Christine J Weydert"'
Autor:
Lyse A Norian, Timothy P Kresowik, Henry M Rosevear, Britnie R James, Timothy R Rosean, Andrew J Lightfoot, Tamara A Kucaba, Christopher Schwarz, Christine J Weydert, Michael D Henry, Thomas S Griffith
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31085 (2012)
Despite evidence that antitumor immunity can be protective against renal cell carcinoma (RCC), few patients respond objectively to immunotherapy and the disease is fatal once metastases develop. We asked to what extent combinatorial immunotherapy wit
Externí odkaz:
https://doaj.org/article/4fe1df20141b475bafe5b1f1f928699e
Autor:
Ram V. Sharma, Christine J. Weydert, Ashley K. Woods, Scott D. Butler, Robin L. Davisson, Yi Zhou, Darren S. Hoffmann
Publikováno v:
Hypertension. 57:94-102
An imbalance in circulating proangiogenic and antiangiogenic factors is postulated to play a causal role in preeclampsia (PE). We have described an inbred mouse strain, BPH/5, which spontaneously develops a PE-like syndrome including late-gestational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a89c812d841f9de5e4faf3edeb513163
https://doi.org/10.1161/hypertensionaha.110.160242
https://doi.org/10.1161/hypertensionaha.110.160242
Autor:
Jingru Liu, Larry W. Oberley, Christine J. Weydert, Wenqing Sun, Yuping Zhang, Douglas R. Spitz, Lei Yu, Joseph J. Cullen
Publikováno v:
Cancers
Volume 2
Issue 1
Pages 68-87
Cancers, Vol 2, Iss 1, Pp 68-87 (2010)
Volume 2
Issue 1
Pages 68-87
Cancers, Vol 2, Iss 1, Pp 68-87 (2010)
Overexpression of manganese superoxide dismutase (MnSOD) can sensitize a variety of cancer cell lines to many anticancer drugs. Recent work has shown that cancer cells can be sensitized to cell killing by raising peroxide levels through increased man
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b1e326adb853da273ab466fd560ee2
http://europepmc.org/articles/PMC2880814
http://europepmc.org/articles/PMC2880814
Autor:
Darren S. Hoffmann, Ram V. Sharma, William J. Kutschke, Christine J. Weydert, Eric Lazartigues, Martha F. Kienzle, Jenny E. Leach, Jennifer A. Sharma, Robin L. Davisson
Publikováno v:
Hypertension. 51:1058-1065
Recently we described a mouse model, BPH/5, that spontaneously develops the hallmark clinical features of preeclampsia. BPH/5 exhibit impaired placentation before the onset of hypertension and proteinuria, supporting a causal role for the placenta in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee5c5c6444c04824a79a794356e4eac6
https://doi.org/10.1161/hypertensionaha.107.107219
https://doi.org/10.1161/hypertensionaha.107.107219
Autor:
Kelly K. Andringa, Brian J. Smith, Yuping Zhang, Douglas R. Spitz, Melissa L.T. Teoh, Trent A. Waugh, Larry W. Oberley, Wenqing Sun, Christine J. Weydert, Nukhet Aykin-Burns
Publikováno v:
Free Radical Biology and Medicine. 44:856-867
Superoxide dismutases (SODs) have been found to decrease tumor formation and angiogenesis. SOD gene therapy, as with many other gene transfer strategies, may not completely inhibit tumor growth on its own. Thus, concomitant therapies are necessary to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08c249d5020e3dfa8c6d12a4523f687c
https://doi.org/10.1016/j.freeradbiomed.2007.11.009
https://doi.org/10.1016/j.freeradbiomed.2007.11.009
Autor:
Sujatha Venkataraman, Freya Q. Schafer, Hannah J. Zhang, Min Wang, Douglas R. Spitz, Larry W. Oberley, Garry R. Buettner, Christine J. Weydert, Frederick E. Domann, Shawn W. Flanagan, Jeanie S Kirk
Publikováno v:
Oncogene. 24:8154-8166
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that governs cellular responses to reduced O2 availability by mediating crucial homeostatic processes. HIF-1 is composed of an HIF-1alpha subunit and an HIF-1beta subunit. HIF-1alpha is deg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2224ce09505d4f9828006d941857817
https://doi.org/10.1038/sj.onc.1208986
https://doi.org/10.1038/sj.onc.1208986
Autor:
Christine J. Weydert, Steven P. Donald, Gregory L. Borchert, Larry W. Oberley, Chien-An Andy Hu, James M. Phang, Yongmin Liu, Arkadiusz Surazynski
Publikováno v:
Carcinogenesis. 26:1335-1342
Proline oxidase (POX), localized on inner mitochondrial membranes, is encoded by a p53-induced gene and metabolically participates in p53-induced apoptosis. Previously, we showed that POX catalyzed the generation of reactive oxygen species (ROS). We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c27eb4f51f8575d72802618380116d1
https://doi.org/10.1093/carcin/bgi083
https://doi.org/10.1093/carcin/bgi083
Autor:
Christine J. Weydert, Justine M. Ritchie, Marilyn M. Hinkhouse, Joseph J. Cullen, Wenqing Sun, Jingru Liu, Larry W. Oberley
Publikováno v:
Human Gene Therapy. 15:239-250
Pancreatic cancer has low levels of antioxidant enzymes including manganese superoxide dismutase (MnSOD), which converts superoxide radical (O(2)(*-)) into hydrogen peroxide (H(2)O(2)), and glutathione peroxidase (GPx), which converts H(2)O(2) into w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0863165c081d13427f5f2573c84b2e7
https://doi.org/10.1089/104303404322886093
https://doi.org/10.1089/104303404322886093
Autor:
Christine J. Weydert, Kevin C. Kregel, Linjing Xu, Larry W. Oberley, Justine M. Ritchie, Charles S. Davis, Benjamin B. Smith
Publikováno v:
Free Radical Biology and Medicine. 34:316-329
We hypothesized that inhibitors of peroxide removal, such as BCNU, an indirect inhibitor of glutathione peroxidase (GPx), and 3-amino-1,2,4-triazole (AT), a direct inhibitor of catalase (CAT), should cause toxicity to cancer cells after manganese sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c93d576af4385946b7d05b6b105822e8
https://doi.org/10.1016/s0891-5849(02)01245-5
https://doi.org/10.1016/s0891-5849(02)01245-5
Publikováno v:
Antioxidants & Redox Signaling. 3:387-395
Activator protein-2 (AP-2) is a transcription factor with transactivating and transrepressing potential in different promoter contexts. AP-2 contains seven cysteines, and its in vitro DNA binding activity is redox-sensitive. Superoxide dismutase-2 (S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b55d0f8dc73e04df00b43350b943b7a
https://doi.org/10.1089/15230860152409031
https://doi.org/10.1089/15230860152409031