Zobrazeno 1 - 10
of 224
pro vyhledávání: '"Christine J, Cardin"'
Publikováno v:
Nucleic Acids Research. 50:12636-12656
The four natural DNA bases (A, T, G and C) associate in base pairs (A=T and G≡C), allowing the attached DNA strands to assemble into the canonical double helix of DNA (or duplex-DNA, also known as B-DNA). The intrinsic supramolecular properties of
Autor:
Benjamin J. Pages, Sarah P. Gurung, Kane McQuaid, James P. Hall, Christine J. Cardin, John A. Brazier
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
A spectroscopic study of the interactions of Λ- and Δ-[Ru(phen)2(dppz)]2+ with i-motif DNA containing thymine loops of various lengths. In the presence of i-motifs, the luminescence of the Λ enantiomer was enhanced much more than the Δ. Despite t
Externí odkaz:
https://doaj.org/article/aebe21fc890c4d8ba760a90996ef0758
Autor:
Kane T. McQuaid, Shuntaro Takahashi, Lena Baumgaertner, David J. Cardin, Neil G. Paterson, James P. Hall, Naoki Sugimoto, Christine J. Cardin
Publikováno v:
Journal of the American Chemical Society. 144:5956-5964
The DNA G-quadruplex is known for forming a range of topologies and for the observed lability of the assembly, con-sistent with its transient formation in live cells. The stabilisation of a particular topology by a small molecule is of great importan
Autor:
Páraic M. Keane, Clara Zehe, Fergus E. Poynton, Sandra A. Bright, Sandra Estayalo-Adrián, Stephen J. Devereux, Paul M. Donaldson, Igor V. Sazanovich, Michael Towrie, Stanley W. Botchway, Christine J. Cardin, D. Clive Williams, Thorfinnur Gunnlaugsson, Conor Long, John M. Kelly, Susan J. Quinn
Publikováno v:
Physical Chemistry Chemical Physics. 24:27524-27531
Time-resolved IR spectra of porphyrins bound to biomolecules are reported. DFT calculations aid porphyrin vibration assignment while distinctive IR bands reveal interactions with therapeutic targets such as quadruplex DNA and proteins in HeLa cells.
Publikováno v:
Chemical Science
Chemical Science, 2022, ⟨10.1039/D2SC01793H⟩
Chemical Science, 2022, ⟨10.1039/D2SC01793H⟩
International audience; DNA is a strikingly flexible molecule and can form a variety of secondary structures, including the triple helix, which is the subject of this review. The DNA triplex may be formed naturally, during homologous recombination, o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a8c1781656293dae29a7056ea45cc6
https://hal.archives-ouvertes.fr/hal-03762871
https://hal.archives-ouvertes.fr/hal-03762871
Autor:
Frederico R. Baptista, Igor V. Sazanovich, Thorfinnur Gunnlaugsson, Fergus E. Poynton, Christine J. Cardin, John M. Kelly, Stephen J. Devereux, Michael Towrie, Susan J. Quinn
Publikováno v:
Chemistry – A European Journal. 26:17103-17109
Ultrafast time-resolved infrared (TRIR) is used to report on the binding site of the [Ru(phen)2 (dppz)]2+ "light-switch" complex with both bimolecular (Oxytricha nova telomere) and intramolecular (human telomere) guanine-quadruplex structures in both
Autor:
Michael Towrie, James P. Hall, Christine J. Cardin, Sarah P. Gurung, Frederico R. Baptista, Stephen J. Devereux, Igor V. Sazanovich, Susan J. Quinn, John M. Kelly, John A. Brazier
Publikováno v:
Chemical Communications. 56:9703-9706
Ultrafast time resolved infrared (TRIR) is used to report on the binding site of the "light-switch" complex [Ru(phen)2(dppz)]2+1 to i-motif structures in solution. Detailed information is provided due to perturbation of the local base vibrations by a
Autor:
Christine J. Cardin, Kane T. McQuaid
Publikováno v:
Handbook of Chemical Biology of Nucleic Acids ISBN: 9789811613135
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68baaab36d48647751ae7122746b321c
https://doi.org/10.1007/978-981-16-1313-5_13-1
https://doi.org/10.1007/978-981-16-1313-5_13-1
Autor:
Christine J. Cardin, Holly Abell, Thomas Sorensen, Kane McQuaid, John A. Brazier, James P. Hall, Graeme Winter, Sarah P. Gurung, David R. Allan, David J. Cardin
Publikováno v:
Angewandte Chemie International Edition. 58:9881-9885
Using X-ray crystallography, we show an enantiospecificity in DNA G-quadruplex binding, using the complexes Λ/∆-[Ru(TAP)2(dppz-11-CN)]2+ (TAP=1,4,5,8-tetraazaphenanthrene) containing the dppz (dipyridophenazine) ligand, paralleling the specificity
Publikováno v:
Chemical Communications. 55:9116-9119
Λ-[Ru(TAP)2(dppz)]2+ was crystallised with the G-quadruplex-forming heptamer d(TAGGGTT). Surprisingly, even though there are four unique binding sites, the complex is not in contact with any G-quartet surface. Two complexes stabilise cavities formed