Výsledky vyhledávání - "Christine I. Furtek"

Safety, Tolerability, and Pharmacokinetics of Escalating High Doses of Ivermectin in Healthy Adult Subjects

Autor: Christine I. Furtek, Robert Tipping, Cong Chen, Arturo G. Porras, Cynthia A Guzzo, David G Sciberras, John Y.-K. Hsieh, Kenneth C. Lasseter, Coleen M Clineschmidt

Publikováno v: The Journal of Clinical Pharmacology. 42:1122-1133

Safety and pharmacokinetics (PK) of the antiparasitic drug ivermectin, administered in higher and/or more frequent doses than currently approved for human use, were evaluated in a double-blind, placebo-controlled, dose escalation study. Subjects (n =

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ac96cfa40989bdf8c68141aa88364ed
https://doi.org/10.1177/009127002237994

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Lack of polymorphism of the conversion of losartan to its active metabolite E-3174 in extensive and poor metabolizers of debrisoquine (cytochrome P450 2D6) and mephenytoin (cytochrome P450 2C19)

Autor: Folke Sjöqvist, M. A. Ritter, B. Jonzon, Gunnar Alván, M.-W. Lo, P. Dalén, Christine I. Furtek, P. Sandwall, Jacqueline B. McCrea

Publikováno v: European Journal of Clinical Pharmacology. 55:279-283

Objective: Losartan was given to subjects with known phenotypes of the polymorphic enzymes CYP2D6 and CYP2C19 to study any possible influence on the metabolism of the drug. Methods: Plasma concentrations of losartan and E-3174 were studied after oral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c47915fc18e99b97476e13e15211670
https://doi.org/10.1007/s002280050629

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Pharmacokinetics of Intravenous and Oral Losartan in Patients with Heart Failure

Autor: Jenny Toh, Man-Wai Lo, Barry F. Uretsky, Ewa J. Rucinska, Michael A. Ritter, Hannah Lu, Christine I. Furtek, Wilson S. Colucci, Scott E. Emmert

Publikováno v: The Journal of Clinical Pharmacology. 38:525-532

The pharmacokinetics of a selective AT1-subtype, nonpeptide, orally active, angiotensin II receptor antagonist, losartan, were characterized in 11 patients with heart failure (New York Heart Association class II, n = 6; class III, n = 4; class IV, n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4731b7b691a21697ec09b3dd896cc9df
https://doi.org/10.1002/j.1552-4604.1998.tb05790.x

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Pharmacokinetics of losartan, an angiotensin II receptor antagonist, and its active metabolite EXP3174 in humans

Autor: Michael R. Goldberg, Man-Wai Lo, Christine I. Furtek, Jacqueline B. McCrea, Hannah Lu, Thorir D. Bjornsson

Publikováno v: Clinical Pharmacology & Therapeutics. 58:641-649

The pharmacokinetics of the angiotensin II receptor antagonist losartan potassium and its active carboxylic acid metabolite EXP3174 were characterized in 18 healthy male subjects after administration of intravenous losartan, intravenous EXP3174, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d279504878375e523c28aaebbc5774ca
https://doi.org/10.1016/0009-9236(95)90020-9

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Effect of within-household reinfestation on design sensitivity

Autor: A. Lawrence Gould, Cong Chen, Cynthia A Guzzo, Christine I. Furtek, Robert Tipping

Publikováno v: Journal of biopharmaceutical statistics. 13(2)

The effect of within-household reinfestation on design sensitivity is investigated through statistical modeling of the reinfestation process. When reinfestation is present, household randomization tends to magnify treatment differences when compared

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a629b732b8e8455b03c43b2317ce27
https://pubmed.ncbi.nlm.nih.gov/12729398

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An observer-blinded study of 1% permethrin creme rinse with and without adjunctive combing in patients with head lice

Autor: Coleen M. Clineschmidt, Michael A. Kolber, Terri L. Meinking, Robert W. Tipping, Cong Chen, Christine I. Furtek, Maria Elena Villar, Cynthia A. Guzzo

Publikováno v: The Journal of pediatrics. 141(5)

Objectives: To determine if NIX (Warner Lambert Healthcare, Morris Plains, NJ) 1% Permethrin Creme Rinse Lice Treatment (1% PLT) without combing will effectively treat ≥95% of patients on day 2 or on day 15; to determine whether combing influences

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e01ddc668d7b2f5f633c38c48eac94
https://pubmed.ncbi.nlm.nih.gov/12410195

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DuP 532, an angiotensin II receptor antagonist: first administration and comparison with losartan

Autor: Jerome Biollaz, David D. Christ, Man-Wai Lo, Michael R. Goldberg, Christine I. Furtek, Juerg Nussberger, Ohad Amit, Hans R. Brunner, Alexandra D. Carides, Valerie Piguet, Rita Chiou

Publikováno v: Clinical pharmacology and therapeutics. 61(1)

We investigated the tolerability and angiotensin II antagonist activity of oral DuP 532 in healthy male subjects. DuP 532 (1 to 200 mg) was well tolerated, with no effect on blood pressure or heart rate. Compared with losartan (100 mg), DuP 532 (200

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a5685f5502e4bcaa89303f5f666e64
https://pubmed.ncbi.nlm.nih.gov/9024174

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