Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Christine Huard"'
Autor:
Ankur Sharma, Christine Huard, Cecile Vernochet, Daniel Ziemek, Kelly M Knowlton, Edyta Tyminski, Theresa Paradis, Ying Zhang, Jessica E C Jones, David von Schack, Christopher T Brown, Patrice M Milos, Anthony J Coyle, Frederic Tremblay, Robert V Martinez
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92608 (2014)
Brown adipose tissue (BAT) plays a pivotal role in promoting energy expenditure by the virtue of uncoupling protein-1 (UCP-1) that differentiates BAT from its energy storing white adipose tissue (WAT) counterpart. The clinical implication of "classic
Externí odkaz:
https://doaj.org/article/35e422420472415ea5da98951dbe7a46
Autor:
Mika M. Tabata, Luqman Mushila Hodgkinson, Tiffany T. Wu, Shufeng Li, Christine Huard, Shanrong Zhao, Donald Bennett, Jillian Johnson, Cassandra Tierney, Wen He, Janet E. Buhlmann, Karen M. Page, Kristen Johnson, Livia Casciola‐Rosen, Lorinda Chung, Kavita Y. Sarin, David Fiorentino
Publikováno v:
Arthritis & Rheumatology.
Autor:
Stefano V Gullà, Stephen P. Berasi, Ryan Bellmore, Steven A. Greenberg, Ankur Sharma, Janet E. Buhlmann, Christine Huard, Edyta Tyminski, Christine Loreth, Anthony J. Coyle, Ryan Nistler, Katrina Meeth, Alireza Kalbasi
Publikováno v:
ImmunoHorizons. 4:332-338
Several human autoimmune diseases are characterized by increased expression of type 1 IFN-stimulated genes in both the peripheral blood and tissue. The contributions of different type I IFNs to this gene signature are uncertain as the type I IFN fami
Autor:
Stefano V Gullà, D.V. Bennett, Christine Huard, Steven A. Greenberg, Anthony J. Coyle, Ruth Ann Vleugels
Publikováno v:
British Journal of Dermatology. 176:1224-1230
SummaryBackground Dermatomyositis (DM) is an autoimmune disease primarily affecting skin and muscle. Objectives The purpose of this study was to determine whether an association exists between clinical skin disease activity as measured by the validat
Autor:
Kathryn R Coser, Ivana Nikolic, Xiuli Huang, Anthony J Faugno, Samuel D Paskin-Flerlage, Stephen P. Berasi, Kari E. Roberts, Geoffrey A. Bocobo, Paul D. Upton, Lai Ming Yung, Rajeev Malhotra, Teresa Dinter, Raymond T. Chung, Kathleen E. Tumelty, Megan E. McNeil, Nicholas W. Morrell, Arthur Lee, Carol S. Lai, Marie-José Goumans, Wei Zheng, Luca Troncone, Christine Huard, Peiran Yang, C. Gregory Elliott, Richard W Channick, Paul B. Yu, Roham T. Zamanian
Publikováno v:
American Journal of Respiratory and Critical Care Medicine, 199(7), 891-902. AMER THORACIC SOC
American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine
RATIONALE: BMP9 (bone morphogenetic protein 9) is a circulating endothelial quiescence factor with protective effects in pulmonary arterial hypertension (PAH). Loss-of-function mutations in BMP9, its receptors, and downstream effectors have been repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c64dbe9c17a8e976df4f924f8d01c0dc
http://hdl.handle.net/1887/122297
http://hdl.handle.net/1887/122297
Autor:
David Fiorentino, Christine Huard, Karen Page, Kristen Johnson, Shanrong Zhao, Mika M. Tabata, Jillian Johnson, Donald V. Bennett, Nareh Marukian, Kavita Y. Sarin
Publikováno v:
Ann Transl Med
Interferon signaling is upregulated in dermatomyositis and thought to play a role in pathogenesis. An interferon gene signature in peripheral blood of dermatomyositis patients correlates with skin disease. However, studies have not analyzed how inter
Autor:
Jing Zhang, Christine Huard, Sung Choe, Michael Cain, Ying Zhang, Yan Liu, Bheem M. Bhat, Ramesh A. Bhat, Stephen P. Berasi, Shoichi Fukayama, Kathryn L Auld, Robert V. Martinez, Wenyan Zhong, Eugene L. Brown
Publikováno v:
Journal of Molecular Endocrinology. 48:177-191
Based on its homology to the estrogen receptor and its roles in osteoblast and chondrocyte differentiation, the orphan nuclear receptor estrogen-related receptor α (ERRα (ESRRA)) is an intriguing therapeutic target for osteoporosis and other bone d
Autor:
Christine Huard, Ying Zhang, Robert V. Martinez, James Tobin, Frédéric Tremblay, Tracy Revett, Ruth E. Gimeno
Publikováno v:
Journal of Biological Chemistry. 284:8136-8147
Adipocyte-secreted proteins play important roles in metabolic regulation through autocrine, paracrine, and endocrine mechanisms. Using transcriptional profiling, we identified coiled-coil domain containing 80 (Ccdc80; also known as DRO1 and URB) as a
Autor:
Lisa Borges-Marcucci, Christine Huard, KehDih Lai, George P. Vlasuk, Douglas C. Harnish, Stephen J. Gardell, Mark J. Evans, Paige E. Mahaney, Julie A. Krueger, Shuguang Wang, Robert V. Martinez
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 296:G543-G552
The nuclear hormone receptor farnesoid X receptor (FXR) plays a critical role in the regulation of bile acid, triglyceride (TG), and cholesterol homeostasis. WAY-362450 (FXR-450/XL335) is a potent synthetic FXR agonist as characterized in luciferase
Autor:
Wenyan Zhong, Ying Sun, Christine Huard, Eugene L. Brown, Janet E. Paulsen, Stephen P. Berasi, Heather H. Shih, Dongmei Li, Ruth E. Gimeno, Robert V. Martinez
Publikováno v:
Journal of Biological Chemistry. 281:27167-27177
Increased hepatic gluconeogenesis is an important contributor to the fasting hyperglycemia found in Type 2 diabetic patients. Low energy states activate the intracellular energy sensor AMP-activated kinase (AMPK). AMPK activation by the AMP mimetic A