Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Christine Hilt"'
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
RAF family kinases transmit signals from activated RAS at the plasma membrane to downstream kinases to control cell proliferation, differentiation and survival. Here the authors shed light on the molecular mechanisms whereby small molecule RAF inhibi
Externí odkaz:
https://doaj.org/article/72b7a7f1b9c84f32af4cc1decc0c0c7c
Autor:
Chiang Yu, Gregory Vite, Simone Oppenheimer, Derek Norris, Harold Malone, Anne Lewin, Daniel Kukral, Bala Krishnan, John T. Hunt, Christine Hilt, Benjamin Henley, Amy Hammell, Ashvinikumar Gavai, Brian Fink, Joseph Fargnoli, Craig Fairchild, Stuart Emanuel, Francis Y. Lee, Tai W. Wong
Supplementary Tables 1-3, Figure Legends 1-6 from Antitumor and Antiangiogenic Activities of BMS-690514, an Inhibitor of Human EGF and VEGF Receptor Kinase Families
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f909ef46a03d1570a27d99c5261e2b
https://doi.org/10.1158/1078-0432.22441917.v1
https://doi.org/10.1158/1078-0432.22441917.v1
Autor:
Chiang Yu, Gregory Vite, Simone Oppenheimer, Derek Norris, Harold Malone, Anne Lewin, Daniel Kukral, Bala Krishnan, John T. Hunt, Christine Hilt, Benjamin Henley, Amy Hammell, Ashvinikumar Gavai, Brian Fink, Joseph Fargnoli, Craig Fairchild, Stuart Emanuel, Francis Y. Lee, Tai W. Wong
Purpose: The extensive involvement of the HER kinases in epithelial cancer suggests that kinase inhibitors targeting this receptor family have the potential for broad spectrum antitumor activity. BMS-690514 potently inhibits all three HER kinases, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a33f1ae66761ffc51c82294bcb244134
https://doi.org/10.1158/1078-0432.c.6518787
https://doi.org/10.1158/1078-0432.c.6518787
Autor:
Chiang Yu, Gregory Vite, Simone Oppenheimer, Derek Norris, Harold Malone, Anne Lewin, Daniel Kukral, Bala Krishnan, John T. Hunt, Christine Hilt, Benjamin Henley, Amy Hammell, Ashvinikumar Gavai, Brian Fink, Joseph Fargnoli, Craig Fairchild, Stuart Emanuel, Francis Y. Lee, Tai W. Wong
Supplementary Figures 1-6 from Antitumor and Antiangiogenic Activities of BMS-690514, an Inhibitor of Human EGF and VEGF Receptor Kinase Families
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10077e61e239f1a813c40834f158a23d
https://doi.org/10.1158/1078-0432.22441920
https://doi.org/10.1158/1078-0432.22441920
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Nature Communications
Nature Communications
First-generation RAF inhibitors paradoxically induce ERK signaling in normal and tumor cells exhibiting RAS activity. Compound-induced RAF dimerization through stabilization of the RAF ON/active state by inhibitors has emerged as a critical contribut
Autor:
Zarei, Kasra, David, Sabina, Pfleger, Claudia Christine Hilt, Berman, Dalia Cecilia, Poolman, Pieter, Gramlich, Oliver W., Bailey, Jane, Kardon, Randy H.
Publikováno v:
Zarei, K, David, S, Pfleger, C C H, Berman, D C, Poolman, P, Gramlich, O W, Bailey, J & Kardon, R H 2018, ' Smartphone app visual function tests in multiple sclerosis patients with and without optic neuritis ', Investigative Ophthalmology & Visual Science, vol. 59, no. 9, 2186 . < https://iovs.arvojournals.org/article.aspx?articleid=2694295 >
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ff64d7a054c8835eb1cbb925ffd34a1e
https://vbn.aau.dk/da/publications/539b4449-45c0-4cac-9b2e-2b2d27461d05
https://vbn.aau.dk/da/publications/539b4449-45c0-4cac-9b2e-2b2d27461d05
Publikováno v:
Magyari, M, Koch-Henriksen, N, Pfleger, C C & Sørensen, P S 2014, ' Gender and autoimmune comorbidity in multiple sclerosis ', Multiple Sclerosis Journal, vol. 20, no. 9, pp. 1244-1251 . https://doi.org/10.1177/1352458514521515
Magyari, M, Koch-Henriksen, N, Pfleger, C C & Sørensen, P S 2014, ' Gender and autoimmune comorbidity in multiple sclerosis ', Multiple sclerosis (Houndmills, Basingstoke, England), vol. 20, no. 9, pp. 1244-1251 . https://doi.org/10.1177/1352458514521515
Magyari, M, Koch-Henriksen, N, Pfleger, C C & Sørensen, P S 2014, ' Gender and autoimmune comorbidity in multiple sclerosis ', Multiple sclerosis (Houndmills, Basingstoke, England), vol. 20, no. 9, pp. 1244-1251 . https://doi.org/10.1177/1352458514521515
Background: The female preponderance in incidence of multiple sclerosis (MS) calls for investigations into sex differences in comorbidity with other autoimmune diseases (ADs). Objectives: To determine whether male and female patients with MS have a h
Autor:
Benjamin J. Henley, Bala Krishnan, Amy Hammell, Daniel W. Kukral, John T. Hunt, Joseph Fargnoli, Brian E. Fink, Derek J. Norris, Francis Y.F. Lee, Chiang Yu, Tai Wai Wong, Christine Hilt, Gregory D. Vite, Harold Malone, Ashvinikumar V. Gavai, Craig R. Fairchild, Stuart Emanuel, Anne Lewin, Simone Oppenheimer
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 17(12)
Purpose: The extensive involvement of the HER kinases in epithelial cancer suggests that kinase inhibitors targeting this receptor family have the potential for broad spectrum antitumor activity. BMS-690514 potently inhibits all three HER kinases, an
Autor:
Egon Stenager, Nils Koch-Henriksen, Esben Meulengracht Flachs, Claudia Christine Hilt Pfleger, Christoffer Johansen
Publikováno v:
Pfleger, C C H, Koch-Henriksen, N, Stenager, E, Flachs, E M & Johansen, C 2009, ' Head injury is not a risk factor for multiple sclerosis: a prospective cohort study ', Multiple Sclerosis, vol. 15, no. 3, pp. 294-8 . https://doi.org/10.1177/1352458508099475
Pfleger, C C H, Koch-Henriksen, N, Stenager, E, Flachs, E M & Johansen, C 2009, ' Head injury is not a risk factor for multiple sclerosis: a prospective cohort study ', Multiple sclerosis, vol. 15, no. 3, pp. 294-298 . https://doi.org/10.1177/1352458508099475
Pfleger, C C H, Koch-Henriksen, N, Stenager, E, Flachs, E M & Johansen, C 2009, ' Head injury is not a risk factor for multiple sclerosis: a prospective cohort study ', Multiple sclerosis, vol. 15, no. 3, pp. 294-298 . https://doi.org/10.1177/1352458508099475
Background The idea of physical trauma being involved in the causation of multiple sclerosis (MS) had been discussed since the earliest description of the illness. Despite the ongoing debate, the proposed association between physical and especially h