Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Christine Hantouche"'
Autor:
Patrick Kim Chiaw, Christine Hantouche, Michael J H Wong, Elizabeth Matthes, Renaud Robert, John W Hanrahan, Alvin Shrier, Jason C Young
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0220984 (2019)
Cystic Fibrosis is caused by mutations in the CFTR anion channel, many of which cause its misfolding and degradation. CFTR folding depends on the Hsc70 and Hsp70 chaperones and their co-chaperone DNAJA1, but Hsc70/Hsp70 is also involved in CFTR degra
Externí odkaz:
https://doaj.org/article/80281f7f22984ccf97aa287ac7cca643
Autor:
John W. Hanrahan, Christine Hantouche, Renaud Robert, Michael J.H. Wong, Jason C. Young, Elizabeth Matthes, Patrick Kim Chiaw, Alvin Shrier
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 8, p e0220984 (2019)
PLoS ONE, Vol 14, Iss 8, p e0220984 (2019)
Cystic Fibrosis is caused by mutations in the CFTR anion channel, many of which cause its misfolding and degradation. CFTR folding depends on the Hsc70 and Hsp70 chaperones and their co-chaperone DNAJA1, but Hsc70/Hsp70 is also involved in CFTR degra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167ae493f1e22029bdae7afffbeaedb5
https://pubmed.ncbi.nlm.nih.gov/31408507
https://pubmed.ncbi.nlm.nih.gov/31408507
Autor:
Alvin Shrier, Brittany Williamson, Joshua Solomon, William C. Valinsky, Christine Hantouche, Jason C. Young
Cardiac long QT syndrome type 2 is caused by mutations in the human ether a go-go-related gene (hERG) potassium channel, many of which cause misfolding and degradation at the endoplasmic reticulum instead of normal trafficking to the cell surface. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e551eb24b17af67928dd852f216f73b
https://europepmc.org/articles/PMC5313101/
https://europepmc.org/articles/PMC5313101/
Autor:
Y C Patel, Jason C. Young, Michael J.H. Wong, Imad Baaklini, Christine Hantouche, Alvin Shrier
Publikováno v:
Journal of Biological Chemistry. 287:41939-41954
DNAJA1 (DJA1/Hdj2) and DNAJA2 (DJA2) are the major J domain partners of human Hsp70/Hsc70 chaperones. Although they have overall similarity with the well characterized type I co-chaperones from yeast and bacteria, they are biologically distinct, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eccb09afd13f56743a3445cc3415acc0
https://doi.org/10.1074/jbc.m112.413278
https://doi.org/10.1074/jbc.m112.413278
Autor:
Valerie E. Walker, Christine Hantouche, Alvin Shrier, Roxana Atanasiu, Michael J.H. Wong, Jason C. Young
Publikováno v:
Journal of Biological Chemistry. 285:3319-3329
Loss of function mutations in the hERG (human ether-a-go-go related gene or KCNH2) potassium channel underlie the proarrhythmic cardiac long QT syndrome type 2. Most often this is a consequence of defective trafficking of hERG mutants to the cell sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::606745c3c9e104b10bba3b5bb2881cb9
https://doi.org/10.1074/jbc.m109.024000
https://doi.org/10.1074/jbc.m109.024000