Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Christine Haenggeli"'
Autor:
Christine Haenggeli, Jean-Pierre Julien, R. Lee Mosley, Natalie Perez, Alok Dhar, Howard E. Gendelman, Jeffrey D. Rothstein
Publikováno v:
Neurobiology of Disease, Vol 26, Iss 1, Pp 146-152 (2007)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. The cause of motor neuron degeneration remains largely unknown, and there is no potent treatment. Overexpression of various human mutant superoxide dismutase-1 (SOD1) genes in
Externí odkaz:
https://doaj.org/article/9091a46c31d8491595831738ca5e6e28
Autor:
Jerònia Lladó, Christine Haenggeli, Andrea Pardo, Victor Wong, Leah Benson, Carol Coccia, Jeffrey D. Rothstein, Jeremy M. Shefner, Nicholas J. Maragakis
Publikováno v:
Neurobiology of Disease, Vol 21, Iss 1, Pp 110-118 (2006)
The transgenic mutant superoxide dismutase (SOD1) mice and rats have been important tools in attempting to understand motor neuron pathology and degeneration but the mechanism behind death in this model has not been studied. We studied the electrophy
Externí odkaz:
https://doaj.org/article/c7f5d4120253499fb8688d810a2e1d7b
Autor:
Nicholas J. Maragakis, Kathie M. Bishop, Mehdi Gasmi, Christine Haenggeli, Angelo C. Lepore, Raymond T. Bartus, Jeffrey D. Rothstein
Publikováno v:
Brain Research. 1185:256-265
The potent neuroprotective activities of neurotrophic factors, including insulin-like growth factor 1 (IGF-1), make them promising candidates for treatment of amyotrophic lateral sclerosis (ALS). In an effort to maximize rate of motor neuron transduc
Publikováno v:
Journal of Applied Physiology. 102:926-932
Amyothrophic lateral sclerosis (ALS) is a progressive, lethal neuromuscular disease that is associated with the degeneration of cortical and spinal motoneurons, leading to atrophy of limb, axial, and respiratory muscles. Patients with ALS invariably
Autor:
Pankaj Gupta, Jeffrey D. Rothstein, Dwight E. Bergles, Yanhua H. Huang, Lin Jin, Zao-Zhong Su, Lucie I. Bruijn, Svetlana Vidensky, Christine Haenggeli, Paul B. Fisher, Dorothy S. Chung, Margaret Dykes Hoberg, Sarjubhai Patel, Shuy Vang Toan, Melissa R. Regan
Publikováno v:
Nature. 433:73-77
Glutamate is the principal excitatory neurotransmitter in the nervous system. Inactivation of synaptic glutamate is handled by the glutamate transporter GLT1 (also known as EAAT2; refs 1, 2), the physiologically dominant astroglial protein. In spite
Autor:
Christine Haenggeli, Ann C. Kato
Publikováno v:
Journal of Neuroscience Methods. 116:119-124
A murine model of motoneuron disease, the wobbler mouse, is characterized by a selective loss of cervical spinal cord motoneurons. To determine the number of motoneurons that degenerate in mice with ongoing disease, we have developed two rapid and re
Autor:
Vivianne L. Tawfik, Natalie Perez, Nancy Nutile-McMenemy, Michael L. LaCroix-Fralish, Christine Haenggeli, Joyce A. DeLeo, Melissa R. Regan, Jeffrey D. Rothstein
Publikováno v:
Neuroscience. 152(4)
We have previously shown that the atypical methylxanthine, propentofylline, reduces mechanical allodynia after peripheral nerve transection in a rodent model of neuropathy. In the present study, we sought to determine whether propentofylline-induced
Autor:
Natalie Perez, Alok Dhar, Christine Haenggeli, Jean-Pierre Julien, Jeffrey D. Rothstein, R. Lee Mosley, Howard E. Gendelman
Publikováno v:
Neurobiology of Disease, Vol 26, Iss 1, Pp 146-152 (2007)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. The cause of motor neuron degeneration remains largely unknown, and there is no potent treatment. Overexpression of various human mutant superoxide dismutase-1 (SOD1) genes in
Autor:
Jeremy M. Shefner, Leah M. Benson, Jeffrey D. Rothstein, Jerònia Lladó, Andrea C. Pardo, Christine Haenggeli, Carol Coccia, Nicholas J. Maragakis, Victor Wong
Publikováno v:
Neurobiology of Disease, Vol 21, Iss 1, Pp 110-118 (2006)
The transgenic mutant superoxide dismutase (SOD1) mice and rats have been important tools in attempting to understand motor neuron pathology and degeneration but the mechanism behind death in this model has not been studied. We studied the electrophy
Autor:
Jerònia Lladó, Nicholas J. Maragakis, Jeffrey D. Rothstein, Evan Y. Snyder, Christine Haenggeli
Publikováno v:
Molecular and cellular neurosciences. 27(3)
Besides their capacity to give rise to neurons and/or glia, neural stem cells (NSCs) appear to inherently secrete neurotrophic factors beneficial to injured neurons. To test this potential, we have implanted NSCs onto or adjacent to spinal cord cultu