Multimodal epigenetic changes and altered NEUROD1 chromatin binding in the mouse hippocampus underlie FOXG1 syndrome

Autor: Ipek Akol, Annalisa Izzo, Fabian Gather, Stefanie Strack, Stefanie Heidrich, Darren Ó hAilín, Alejandro Villarreal, Christine Hacker, Tudor Rauleac, Chiara Bella, Andre Fischer, Thomas Manke, Tanja Vogel

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America 120(2), e2122467120 (2023). doi:10.1073/pnas.2122467120
Proceedings of the National Academy of Sciences of the United States of America

Forkhead box G1 (FOXG1) has important functions in neuronal differentiation and balances excitatory/inhibitory network activity. Thus far, molecular processes underlying FOXG1 function are largely unexplored. Here, we present a multiomics data set ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a63bc501a1af10cdc8ad232f77a2ac2
https://pub.dzne.de/record/169280

ZFP36L1 is regulated by growth factors and cytokines in keratinocytes and influences their VEGF production

Autor: Ralitsa S. Valchanova, Stephanie Adams, Barbara Munz, Christine Hacker

Publikováno v: Growth Factors. 28:178-190

Keratinocyte-derived growth factors and cytokines play an important role in epidermal homeostasis and particularly in cutaneous wound repair. Thus, we analyzed a potential role of the ZFP36/tristetraprolin family of zinc finger proteins, which are ta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362114995a317cb1d5d299e3c0334a6b
https://doi.org/10.3109/08977190903578660

Thyroid hormone regulates the obesity gene tub

Autor: Mathias F. Heikenwälder, Alberto Muñoz, Steffen M. Kurz, Manuel Álvarez-Dolado, Christine Hacker, Martin Zenke, Frank Vogel, Nicolás P. Koritschoner

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Thyroid hormone T3/T4 is a major regulator of energy metabolism in vertebrates, and defects in thyroid status are frequently associated with changes in body weight. It is demonstrated here that thyroid hormone regulates in vivo and in vitro the tub g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679da712e9e2f758f45d3b304e0deff7
https://doi.org/10.1093/embo-reports/kve107

Biosynthesis of Taxol: Enzymatic Acetylation of 10-Deacetylbaccatin-III to Baccatin-III in Crude Extracts from Roots ofTaxus baccata

Autor: Bettina Kammer, Christine Hacker, Till Hornbogen, Wolfram Weckwerth, Dietrich Ewald, Rainer Zocher

Publikováno v: Biochemical and Biophysical Research Communications. 229:16-20

The biosynthesis of taxol is a multistep process. One intermediate reaction is the acetylation of 10-deacetylbaccatin-III (10-DAB) to baccatin-III, an assumed precursor of taxol. Here we describe the cell free acetylation of 10-DAB in crude extracts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::718b480adb6c2fc57f975e922aa3a55f
https://doi.org/10.1006/bbrc.1996.1751

Pluripotency associated genes are reactivated by chromatin-modifying agents in neurosphere cells

Autor: Roberto Ensenat‐Waser, Timo C. Dinger, Alexandra Rolletschek, Anna M. Wobus, Duttu S. Vallabhapurapu, Thomas Hieronymus, Martin Zenke, David Ruau, Christine Hacker, Albrecht M. Müller

Publikováno v: Stem cells (Dayton, Ohio). 26(4)

Chromatin architecture in stem cells determines the pattern of gene expression and thereby cell identity and fate. The chromatin-modifying agents trichostatin A (TSA) and 5-Aza-2′-deoxycytidine (AzaC) affect histone acetylation and DNA methylation,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f93e6b0a5385f820d9a98764f6fce744
https://pubmed.ncbi.nlm.nih.gov/18203677