Výsledky vyhledávání - "Christine H Healan-Greenberg"

A Human Immunodeficiency Virus Protease Inhibitor Is a Novel Functional Inhibitor of Human Pregnane X Receptor

Autor: Christine H Healan-Greenberg, Dale J. Kempf, Jeffrey F. Waring, Rommel G. Tirona, Richard B. Kim, Eric A.G. Blomme

Publikováno v: Drug Metabolism and Disposition. 36:500-507

Drug-drug interactions involving induction of cytochrome P450 enzymes (P450s) can lead to loss of drug efficacy. Certain drugs, particularly those used to treat mycobacterial and human immunodeficiency virus (HIV) infections, are especially prone to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a65ae4b42d4ee5ac4c7f32145560f3b5
https://doi.org/10.1124/dmd.107.019547

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Gene Expression Analysis in Rats Treated with Experimental Acetyl-Coenzyme A Carboxylase Inhibitors Suggests Interactions with the Peroxisome Proliferator-Activated Receptor α Pathway

Autor: Xiaojun Wang, Andrew L. Adler, Andrew R. Lisowski, Heidi S. Camp, Bradley A. Zinker, Jeffrey F. Waring, Scott E. Warder, Teresa Mcnally, Yi Yang, Yu Gui Gu, Xiangdong Xu, Eric A.G. Blomme, Moshe Weitzberg, Robert Dickinson, Christine H Healan-Greenberg

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 324:507-516

Acetyl CoA carboxylase (ACC) 2, which catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA, has been identified as a potential target for type 2 diabetes and obesity. Small-molecule inhibitors of ACC2 would be expected to reduce de novo lipi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6ce83ab778b186c59ca2fd92bba088
https://doi.org/10.1124/jpet.107.126938

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N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy derivatives as acetyl-coA carboxylase inhibitors--improvement of cardiovascular and neurological liabilities via structural modifications

Publikováno v: Journal of medicinal chemistry. 50(5)

A preliminary safety evaluation of ACC2 inhibitor 1-(S) revealed serious neurological and cardiovascular liabilities of this chemotype. A systematic structure-toxicity relationship study identified the alkyne linker as the key motif responsible for t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1688a54fd2d6e83db7ff5cfe8990bf69
https://pubmed.ncbi.nlm.nih.gov/17298049

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Akademický článek

N-3-2-(4-Alkoxyphenoxy)thiazol-5-yl-1-methylprop-2-ynylcarboxy Derivatives as Acetyl-CoA Carboxylase InhibitorsImprovement of Cardiovascular and Neurological Liabilities via Structural Modifications.

Publikováno v: Journal of Medicinal Chemistry; Mar2007, Vol. 50 Issue 5, p1078-1082, 5p

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