Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Christine Häger"'
Publikováno v:
Systematic Reviews, Vol 13, Iss 1, Pp 1-12 (2024)
Abstract While undisputedly important, and part of any systematic review (SR) by definition, evaluation of the risk of bias within the included studies is one of the most time-consuming parts of performing an SR. In this paper, we describe a case stu
Externí odkaz:
https://doaj.org/article/a0ca4641c49d44a284aeda90383e0878
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The nasal potential difference test (nPD) is an electrophysiological measurement which is altered in patients and animal models with cystic fibrosis (CF). Because protocols and outcomes vary substantially between laboratories, there are conc
Externí odkaz:
https://doaj.org/article/2b787f74d6544fcda951f00599afdd51
Autor:
Steven R. Talbot, Simone Kumstel, Benjamin Schulz, Guanglin Tang, Ahmed Abdelrahman, Nico Seume, Edgar H. U. Wendt, Johanna Eichberg, Christine Häger, André Bleich, Brigitte Vollmar, Dietmar Zechner
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract The fundament of an evidence-based severity assessment in laboratory animal science is reliable distress parameters. Many readouts are used to evaluate and determine animal distress and the severity of experimental procedures. Therefore, we
Externí odkaz:
https://doaj.org/article/59b5dab59e6e456a83548cc162f6ed59
Autor:
Pia Pascale Peppermüller, Jonathan Gehring, Eva Zentrich, André Bleich, Christine Häger, Manuela Buettner
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
IntroductionBacterial infections and chronic intestinal inflammations triggered by genetic susceptibility, environment or an imbalance in the intestinal microbiome are usually long-lasting and painful diseases in which the development and maintenance
Externí odkaz:
https://doaj.org/article/757c2f7cd6d240eab61b7e3c54863de9
Publikováno v:
Diagnostics, Vol 13, Iss 19, p 3098 (2023)
To address unmet treatment needs in cystic fibrosis (CF), preclinical and clinical studies are warranted. Because it directly reflects the function of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR), the nasal potential difference test
Externí odkaz:
https://doaj.org/article/289a3490da10494aa11eb5e8fbe5d512
Autor:
Lucas Mösch, Janosch Kunczik, Lukas Breuer, Dorit Merhof, Peter Gass, Heidrun Potschka, Dietmar Zechner, Brigitte Vollmar, René Tolba, Christine Häger, André Bleich, Michael Czaplik, Carina Barbosa Pereira
Publikováno v:
PLoS ONE, Vol 18, Iss 9, p e0286230 (2023)
This study presents a novel concept for a smart home cage design, tools, and software used to monitor the physiological parameters of mice and rats in animal-based experiments. The proposed system focuses on monitoring key clinical parameters, includ
Externí odkaz:
https://doaj.org/article/cf27ac11a6d04ccba17afde45c885a2c
Autor:
Steven R. Talbot, Birgitta Struve, Laura Wassermann, Miriam Heider, Nora Weegh, Tilo Knape, Martine C. J. Hofmann, Andreas von Knethen, Paulin Jirkof, Christine Häger, André Bleich
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
Good science in translational research requires good animal welfare according to the principles of 3Rs. In many countries, determining animal welfare is a mandatory legal requirement, implying a categorization of animal suffering, traditionally domin
Externí odkaz:
https://doaj.org/article/a4fc9e7b330b43b6bb9893ea57bb909b
Autor:
Katharina Aulehner, Cathalijn Leenaars, Verena Buchecker, Helen Stirling, Katharina Schönhoff, Hannah King, Christine Häger, Ines Koska, Paulin Jirkof, André Bleich, Marion Bankstahl, Heidrun Potschka
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
Several studies suggested an informative value of behavioral and grimace scale parameters for the detection of pain. However, the robustness and reliability of the parameters as well as the current extent of implementation are still largely unknown.
Externí odkaz:
https://doaj.org/article/23030b4e1e6c4f649c5557650a915b66
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
For ethical and legal reasons it is necessary to assess the severity of procedures in animal experimentation. To estimate the degree of pain, suffering, distress or lasting harm, objective methods that provide gradebale parameters need to be tested a
Externí odkaz:
https://doaj.org/article/5ba1b62ab3ca40488f2af06494317e5d
Autor:
Nora Weegh, Eva Zentrich, Dietmar Zechner, Birgitta Struve, Laura Wassermann, Steven Roger Talbot, Simone Kumstel, Miriam Heider, Brigitte Vollmar, André Bleich, Christine Häger
Publikováno v:
PLoS ONE, Vol 16, Iss 12, p e0261662 (2021)
Laboratory animals frequently undergo routine experimental procedures such as handling, restraining and injections. However, as a known source of stress, these procedures potentially impact study outcome and data quality. In the present study, we, th
Externí odkaz:
https://doaj.org/article/e609b1f29e774138bfdbd8fae1acc3c1