Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Christine Gravier‑Pelletier"'
Autor:
Mélanie Faria da Cunha, Iwona Pranke, Ali Sassi, Christiane Schreiweis, Stéphanie Moriceau, Dragana Vidovic, Aurélie Hatton, Mariane Sylvia Carlon, Geordie Creste, Farouk Berhal, Guillaume Prestat, Romain Freund, Norbert Odolczyk, Jean Philippe Jais, Christine Gravier-Pelletier, Piotr Zielenkiewicz, Vincent Jullien, Alexandre Hinzpeter, Franck Oury, Aleksander Edelman, Isabelle Sermet-Gaudelus
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Mutations in the Cystic Fibrosis Transmembrane Conductance Regulator gene (CFTR) are responsible for Cystic Fibrosis (CF). The most common CF-causing mutation is the deletion of the 508th amino-acid of CFTR (F508del), leading to dysregulatio
Externí odkaz:
https://doaj.org/article/b8ed4d53b6aa41a99e5f64c0f4e97140
Autor:
Sara Bitam, Ahmad Elbahnsi, Geordie Creste, Iwona Pranke, Benoit Chevalier, Farouk Berhal, Brice Hoffmann, Nathalie Servel, Danielle Tondelier, Aurelie Hatton, Christelle Moquereau, Mélanie Faria Da Cunha, Alexandra Pastor, Agathe Lepissier, Alexandre Hinzpeter, Jean-Paul Mornon, Guillaume Prestat, Aleksander Edelman, Isabelle Callebaut, Christine Gravier-Pelletier, Isabelle Sermet-Gaudelus
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract C407 is a compound that corrects the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein carrying the p.Phe508del (F508del) mutation. We investigated the corrector effect of c407 and its derivatives on F508del-CFTR protein. Mo
Externí odkaz:
https://doaj.org/article/c78c19594a5d4a81b0e0face0bb082c4
Autor:
Hongwei Wan, Raja Ben Othman, Laurent Le Corre, Mélanie Poinsot, Martin Oliver, Ana Amoroso, Bernard Joris, Thierry Touzé, Rodolphe Auger, Sandrine Calvet-Vitale, Michaël Bosco, Christine Gravier-Pelletier
Publikováno v:
Antibiotics, Vol 11, Iss 9, p 1189 (2022)
New inhibitors of the bacterial transferase MraY from Aquifex aeolicus (MraYAA), based on the aminoribosyl uridine central core of known natural MraY inhibitors, have been designed to generate interaction of their oxadiazole linker with the key amino
Externí odkaz:
https://doaj.org/article/898629507e3f462091e3a65387a522ea
Autor:
Sara Bitam, Ahmad Elbahnsi, Geordie Creste, Iwona Pranke, Benoit Chevalier, Farouk Berhal, Brice Hoffmann, Nathalie Servel, Nesrine Baatalah, Danielle Tondelier, Aurelie Hatton, Christelle Moquereau, Mélanie Faria Da Cunha, Alexandra Pastor, Agathe Lepissier, Alexandre Hinzpeter, Jean‑Paul Mornon, Guillaume Prestat, Aleksander Edelman, Isabelle Callebaut, Christine Gravier‑Pelletier, Isabelle Sermet‑Gaudelus
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://doaj.org/article/ffc4fc65088a4bea941ed1fade26fee8
Autor:
Martin Oliver, Laurent Le Corre, Mélanie Poinsot, Michaël Bosco, Hongwei Wan, Ana Amoroso, Bernard Joris, Ahmed Bouhss, Sandrine Calvet-Vitale, Christine Gravier-Pelletier
Publikováno v:
Molecules, Vol 27, Iss 6, p 1769 (2022)
New inhibitors of the bacterial tranferase MraY are described. Their structure is based on an aminoribosyl uridine scaffold, which is known to be important for the biological activity of natural MraY inhibitors. A decyl alkyl chain was introduced ont
Externí odkaz:
https://doaj.org/article/21f58ea949fc468d8947943dab983c17
Autor:
Cécile Morlot, Daniel Straume, Katharina Peters, Olav A. Hegnar, Nolwenn Simon, Anne-Marie Villard, Carlos Contreras-Martel, Francisco Leisico, Eefjan Breukink, Christine Gravier-Pelletier, Laurent Le Corre, Waldemar Vollmer, Nicolas Pietrancosta, Leiv Sigve Håvarstein, André Zapun
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
The amidotransferase MurT/GatD complex catalyzes peptidoglycan precursor amidation in some Gram-positive bacteria. Here the authors present the crystal structure of the Streptococcus pneumoniae MurT/GatD complex and provide mechanistic insights, whic
Externí odkaz:
https://doaj.org/article/4e8f7d6353d84e29a4d53b28f4a9d9e8
Publikováno v:
Molecules, Vol 26, Iss 18, p 5467 (2021)
Quinoline is a versatile heterocycle that is part of numerous natural products and countless drugs. During the last decades, this scaffold also became widely used as ligand in organometallic catalysis. Therefore, access to functionalized quinolines i
Externí odkaz:
https://doaj.org/article/19483694b3354c39a2e07cde9c597cdd
Autor:
Raja Ben Othman, Mickaël J. Fer, Laurent Le Corre, Sandrine Calvet-Vitale, Christine Gravier-Pelletier
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 1533-1541 (2017)
The 5’-alkynylation of uridine-derived aldehydes is described. The addition of alkynyl Grignard reagents on the carbonyl group is significantly influenced by the 2’,3’-di-O-protecting groups (R1): O-alkyl groups led to modest diastereoselectivi
Externí odkaz:
https://doaj.org/article/3b7cabef124f4c70987d30b1fcb59542
Autor:
Ahmad Massarweh, Michaël Bosco, Soria Iatmanen-Harbi, Clarice Tessier, Laura Amana, Patricia Busca, Isabelle Chantret, Christine Gravier-Pelletier, Stuart E.H. Moore
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 8, Pp 1477-1491 (2016)
We reported an oligosaccharide diphosphodolichol (DLO) diphosphatase (DLODP) that generates dolichyl-phosphate and oligosaccharyl phosphates (OSPs) from DLO in vitro. This enzyme could underlie cytoplasmic OSP generation and promote dolichyl-phosphat
Externí odkaz:
https://doaj.org/article/9a77360137a44117ae0fe955a561a1d6
Autor:
Ahmad Massarweh, Michaël Bosco, Soria Iatmanen-Harbi, Clarice Tessier, Nicolas Auberger, Patricia Busca, Isabelle Chantret, Christine Gravier-Pelletier, Stuart E.H. Moore
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 6, Pp 1029-1042 (2016)
Oligosaccharyl phosphates (OSPs) are hydrolyzed from oligosaccharide-diphosphodolichol (DLO) during protein N-glycosylation by an uncharacterized process. An OSP-generating activity has been reported in vitro, and here we asked if its biochemical cha
Externí odkaz:
https://doaj.org/article/b9d56dab62e34c5886594ebde4e64040