Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Christine Gjerdrum"'
1
Abstract LB-180: A human breast cancer 3D spheroid platform for microscopy based high throughput screening
Autor: Jeffrey H. Price, Robert G. Oshima, Patrick M. McDonough, Kara L. Gordon, Alexey V. Terskikh, Alyson S. Smith, Christine Gjerdrum Rines, Ranor C.B. Basa, Chen Farhy
Publikováno v: Cancer Research. 80:LB-180
Breast cancer (BC) tumors originate in epithelial cells and rank second as a cause of cancer-related death in women (in 2020, ~270,000 women will be diagnosed, and 42,000 women will die from this disease in the USA). While important progress has been
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27a8138f387c388c48b0e8099df104b3
https://doi.org/10.1158/1538-7445.am2020-lb-180
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2
Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer
Autor: Johanna Ivaska, James B. Lorens, Christine Gjerdrum, John Mpindi, Hallvard Haugen, Jonna Nevo, Kiviluoto S, Karoliina Vuoriluoto, Crina Tiron
Publikováno v: Vuoriluoto, K, Haugen, H, Kiviluoto, S, Mpindi, J, Nevo, J, Gjerdrum, C, Tiron, C, Lorens, J B & Ivaska, J 2011, ' Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer ', Oncogene, vol. 30, no. 12, pp. 1436-1448 . https://doi.org/10.1038/onc.2010.509
Oncogene
Epithelial-to-mesenchymal transition (EMT) is a critical event in the progression toward cancer metastasis. The intermediate filament protein vimentin is an important marker of EMT and a requisite regulator of mesenchymal cell migration. However, it
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25a740e67bbe0924640d08ae8813d842
https://cris.vtt.fi/en/publications/f7943148-1b91-498d-b854-3123bc8085d9
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3
Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival
Autor: Shan Li, Hallvard Haugen, Christine Gjerdrum, Karin Collett, Lars A. Akslen, Ingunn M. Stefansson, Carlotta A. Glackin, Tone Sandal, Crina Tiron, Emmet McCormack, Torill Høiby, David Micklem, James B. Lorens, Bjørn Tore Gjertsen
Publikováno v: ResearcherID
Metastasis underlies the majority of cancer-related deaths. Thus, furthering our understanding of the molecular mechanisms that enable tumor cell dissemination is a vital health issue. Epithelial-to-mesenchymal transitions (EMTs) endow carcinoma cell
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b585b86a72b7929a3d9cf1f76f7a3588
https://europepmc.org/articles/PMC2824310/
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5
The level of synthesis and secretion of Gaussia princeps luciferase in transfected CHO cells is heavily dependent on the choice of signal peptide
Autor: Beate Stern, Hanne Ravneberg, Christine Gjerdrum, Stian Knappskog, Ian F. Pryme, Christiane Trösse
Publikováno v: Journal of biotechnology. 128(4)
There is a great demand for the improvement of mammalian cell production systems such that they can compete economically with their prokaryotic counterparts. Of a number of parameters that need to be explored to accomplish this we have tested the eff
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6487dbd66ac9a0316b765e8909314ef0
https://pubmed.ncbi.nlm.nih.gov/17316861
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6
Flow cytometry-based functional selection of RNA interference triggers for efficient epi-allelic analysis of therapeutic targets
Autor: Erlend Hodneland, Torill Høiby, James B. Lorens, Ola Hammarsten, David Micklem, Christine Gjerdrum, Magnus Blø, Crina Tiron, Petra Bergström
Publikováno v: BMC Biotechnology
Background: The dose-response relationship is a fundamental pharmacological parameter necessary to determine therapeutic thresholds. Epi-allelic hypomorphic analysis using RNA interference (RNAi) can similarly correlate target gene dosage with cellul
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c22862e649ac54d4eca4df8407e001c9
http://europepmc.org/articles/PMC4074332
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7
Functional role of the HIV-1 Rev exon 1 encoded region in complex formation and trans-dominant inhibition
Autor: Anne Marie Szilvay, Annicke Stranda, Christine Gjerdrum
Publikováno v: FEBS letters. 495(1-2)
To study functional aspects of the exon 1 encoded region of the human immunodeficiency virus type 1 Rev protein, the viral Tev protein which exhibits low Rev activity but lacks the rev exon 1 encoded region was examined. Neither Rev–Tev heteromer c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79179c3d985d90e14d306a3541a7bec
https://pubmed.ncbi.nlm.nih.gov/11322956
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8
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9
Abstract B105: Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival
Autor: Lars A. Akslen, Torill Høiby, Ingunn M. Stefansson, Shan Li, David Micklem, Bjørn Tore Gjertsen, Tone Sandal, Hallvard Haugen, Carlotta A. Glackin, James B. Lorens, Karin Collet, Christine Gjerdrum, Crina Tiron, Emmet McCormack
Publikováno v: Molecular Cancer Therapeutics. 8:B105-B105
Metastasis underlies the majority of cancer-related deaths. Hence, furthering our understanding of the molecular mechanisms that enable tumor cell dissemination is a vital health issue. Epithelial-to-mesenchymal transitions (EMT) endow carcinoma cell
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65f6de95d79bfad27f41387ac9b8e55d
https://doi.org/10.1158/1535-7163.targ-09-b105
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