Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Christine G. Smothers"'
Autor:
Grant C. O’Connell, Kyle B. Walsh, Christine G. Smothers, Suebsarn Ruksakulpiwat, Bethany L. Armentrout, Chris Winkelman, Truman J. Milling, Steven J. Warach, Taura L. Barr
Publikováno v:
BMC Neurology, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Background The development of tools that could help emergency department clinicians recognize stroke during triage could reduce treatment delays and improve patient outcomes. Growing evidence suggests that stroke is associated with several c
Externí odkaz:
https://doaj.org/article/310a178bda384b22bf7c3a447a591363
Publikováno v:
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 94
Our group recently performed a genome-wide informatic analysis that highlighted eight brain-enriched proteins with strong potential to serve as blood biomarkers of neurological injury (GFAP, MBP, β-synuclein, OPALIN, MT-3, SNAP-25, KIF5A, MOBP), inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798084ef36f299bdc0b89eda51891631
https://pubmed.ncbi.nlm.nih.gov/34863423
https://pubmed.ncbi.nlm.nih.gov/34863423
Publikováno v:
Proc Natl Acad Sci U S A
The identification of precision blood biomarkers which can accurately indicate damage to brain tissue could yield molecular diagnostics with the potential to improve how we detect and treat neurological pathologies. However, a majority of candidate b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03aa33f2a644e5040b8a625ca0f35d1d
https://pubmed.ncbi.nlm.nih.gov/32764143
https://pubmed.ncbi.nlm.nih.gov/32764143
Autor:
Carolyn H Still, Megan L. Alder, Christine G. Smothers, Grant C. O’Connell, Shirley M. Moore, Allison R. Webel
Publikováno v:
Neurol Res
BACKGROUND: Historically, limited sensitivity associated with traditional immunoassay methods have prevented the use of brain-specific proteins as blood biomarkers of traumatic brain injury (TBI) during triage, as these proteins exhibit low concentra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f1f7fda67f1053d0e7c63017e244e58
https://europepmc.org/articles/PMC7192520/
https://europepmc.org/articles/PMC7192520/
Autor:
Megan L. Alder, Carolyn H Still, Grant C. O’Connell, Allison R. Webel, Shirley M. Moore, Christine G. Smothers
Publikováno v:
Brain Res
Limited lower detection ranges associated with traditional immunoassay techniques have prevented the use of brain-specific proteins as blood biomarkers of stroke in the acute phase of care, as these proteins are often only present in circulation at l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a71ec10c5059aa1cbbf1a3bc515ef0cf
https://pubmed.ncbi.nlm.nih.gov/32353434
https://pubmed.ncbi.nlm.nih.gov/32353434
BackgroundDetection of brain-specific miRNAs in the peripheral blood could serve as a surrogate marker of traumatic brain injury (TBI). Here, we systematically identified brain-enriched miRNAs, and tested their utility for use as TBI biomarkers in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b81f64a8bd3fa9bc4d6db322a597d693
https://doi.org/10.1101/794321
https://doi.org/10.1101/794321
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2431a4ce74764604d109ca1d436af5d
https://doi.org/10.1096/fasebj.2019.33.1_supplement.lb339
https://doi.org/10.1096/fasebj.2019.33.1_supplement.lb339
Publikováno v:
Journal of Biological Methods
Bias and background issues make efficient amplification of complex template mixes such as aptamer and genomic DNA libraries via conventional PCR methods difficult; emulsion PCR is being increasingly used in such scenarios to circumvent these problems
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117f65ad9bb1fc9b1ce09feb9c5ab1e7
https://doi.org/10.14440/jbm.2020.316
https://doi.org/10.14440/jbm.2020.316
Autor:
O'Connell, Grant C.1,2 (AUTHOR) grant.oconnell@case.edu, Walsh, Kyle B.3,4 (AUTHOR), Smothers, Christine G.1 (AUTHOR), Ruksakulpiwat, Suebsarn1 (AUTHOR), Armentrout, Bethany L.1 (AUTHOR), Winkelman, Chris1 (AUTHOR), Milling, Truman J.5 (AUTHOR), Warach, Steven J.5 (AUTHOR), Barr, Taura L.6,7 (AUTHOR)
Publikováno v:
BMC Neurology. 6/3/2022, Vol. 22 Issue 1, p1-13. 13p.
Publikováno v:
Brain Injury; 2020, Vol. 34 Issue 7, p965-974, 10p