Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christine Fregeau"'
Autor:
Jessica D. Weaver, Edward C. Stack, Joshua A. Buggé, Changyun Hu, Lara McGrath, Amy Mueller, Masie Wong, Boris Klebanov, Tanzila Rahman, Rosemary Kaufman, Christine Fregeau, Vikki Spaulding, Michelle Priess, Kristen Legendre, Sarah Jaffe, Dhruvkumar Upadhyay, Anirudh Singh, Chang-Ai Xu, Kristin Krukenberg, Yan Zhang, Yassine Ezzyat, Dorothée Saddier Axe, Michelle R. Kuhne, Michael A. Meehl, Donald R. Shaffer, Brian M. Weist, Dmitri Wiederschain, Fabien Depis, Monica Gostissa
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
The presence of T regulatory (Treg) cells in the tumor microenvironment is associated with poor prognosis and resistance to therapies aimed at reactivating anti-tumor immune responses. Therefore, depletion of tumor-infiltrating Tregs is a potential a
Externí odkaz:
https://doaj.org/article/9a4049560acc4a71971464efbe2cc5d2
Autor:
Benjamin Umiker, Hyun-Hee Lee, Julia Cope, Nadim J. Ajami, Jean-Philippe Laine, Christine Fregeau, Heidi Ferguson, Stephen E Alves, Nunzio Sciammetta, Melanie Kleinschek, Michael Salmon
Publikováno v:
Innate Immunity, Vol 25 (2019)
Crohn’s disease (CD) is a chronic disorder of the gastrointestinal tract characterized by inflammation and intestinal epithelial injury. Loss of function mutations in the intracellular bacterial sensor NOD2 are major risk factors for the developmen
Externí odkaz:
https://doaj.org/article/cc0221bbdaa040889d91e9a575c129f6
Autor:
Stephen E. Alves, Christine Fregeau, Nadim J. Ajami, Julia L. Cope, Michael Salmon, Jean-Philippe Laine, Nunzio Sciammetta, Hyun-Hee Lee, Heidi Ferguson, Melanie A. Kleinschek, Benjamin R. Umiker
Publikováno v:
Innate Immunity
Crohn’s disease (CD) is a chronic disorder of the gastrointestinal tract characterized by inflammation and intestinal epithelial injury. Loss of function mutations in the intracellular bacterial sensor NOD2 are major risk factors for the developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfa874f14b54bb52149878cc6fab7643
https://doi.org/10.1177/1753425919826367
https://doi.org/10.1177/1753425919826367
Autor:
Donald R. Shaffer, Seema Naheed, Chang-Ai Xu, Michael A. Meehl, Jessica Weaver, Monica Gostissa, Edward C. Stack, Joshua Adam Buggé, Masie Wong, Yan Zhang, Vikki Spaulding, Margaret Willer, Alessandro Mora, Anirudh Singh, Kristan Meetze, Lara McGrath, Boris Klebanov, Christine Fregeau, Fabien Dépis, Dhruvkumar Upadhyay, Michelle Priess, Changyun Hu, Ben Umiker, Kristin Legendre
Publikováno v:
Cancer Research. 80:4532-4532
Introduction: Immune checkpoint blockade (ICB) has revolutionized the treatment of many cancers, still most patients do not respond to PD-1 or CTLA-4 inhibitors. Thus, new Immuno-Oncology (IO) therapies that could potentially benefit non-responding p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14b5213193fab5060f3cc3592ee811dd
https://doi.org/10.1158/1538-7445.am2020-4532
https://doi.org/10.1158/1538-7445.am2020-4532
Autor:
Susan C. Nicholson, George L. Drusano, Christine Fregeau, James B. Kahn, Arnold Louie, Weiguo Liu, Brian Morrow, Mohammed Khashab, Brian Van Scoy, David Brown, Karen Bush, Adam Bied, Anne-Marie Queenan, Robert Kulawy
Publikováno v:
Antimicrobial Agents and Chemotherapy. 54:2638-2645
We compared drugs (imipenem and doripenem), doses (500 mg and 1 g), and infusion times (0.5 and 1.0 [imipenem], 1.0 and 4.0 h [doripenem]) in our hollow-fiber model, examining cell kill and resistance suppression for three isogenic strains of Pseudom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1fad088b3b024d37fa21e8a2a8e8945
https://doi.org/10.1128/aac.01721-09
https://doi.org/10.1128/aac.01721-09
Publikováno v:
Antimicrobial Agents and Chemotherapy. 53:3325-3330
The dose choice for Pseudomonas aeruginosa remains a matter of debate. The actual exposure targets required for multilog killing of organisms at the primary infection site have not been delineated. We studied Pseudomonas aeruginosa PAO1 using a murin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912848c8c28a25a682d368bf2534e01d
https://doi.org/10.1128/aac.00006-09
https://doi.org/10.1128/aac.00006-09
Autor:
Weiguo Liu, Arnold Louie, Christine Fregeau, George L. Drusano, Haley Conde, Julia Zack, Brian VanScoy, Daniel S. Stein
Publikováno v:
Antimicrobial agents and chemotherapy. 55(7)
Systemic candidiasis causes significant mortality in patients despite amphotericin B (AMB) therapy. Mycograb C28Y variant, a human recombinant antibody fragment to heat shock protein 90, is closely related to Mycograb, which showed a survival advanta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1cd78f202bf4e3534c7c7045a90f08
https://pubmed.ncbi.nlm.nih.gov/21502626
https://pubmed.ncbi.nlm.nih.gov/21502626
Autor:
Martina Kinzig, Arnold Louie, Christine Fregeau, Henry S. Heine, Olanrewaju O. Okusanya, B. van Scoy, George L. Drusano, A. O. Okusanya, David L. Brown, Robert Kulawy, Fritz Sörgel
Bacillus anthracis is complex because of its spore form. The spore is invulnerable to antibiotic action. It also has an impact on the emergence of resistance. We employed the hollow-fiber infection model to study the impacts of different doses and sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f619c7dc5ccd1f7e0813a30bcd54cf7
https://europepmc.org/articles/PMC2772353/
https://europepmc.org/articles/PMC2772353/
Publikováno v:
Antimicrobial agents and chemotherapy. 53(6)
The drug interaction terminology (synergy, additivity, antagonism) relates to bacterial kill. The suppression of resistance requires greater drug exposure. We examined the combination of meropenem and tobramycin for kill and resistance suppression (w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::053b437def3c3a02d792ded9be14d99b
https://pubmed.ncbi.nlm.nih.gov/19289521
https://pubmed.ncbi.nlm.nih.gov/19289521
Autor:
Tawanda Gumbo, Weiguo Liu, Robert Kulawy, Christine Fregeau, Vasha Hsu, Arnold Louie, George L. Drusano
Publikováno v:
Antimicrobial agents and chemotherapy. 51(3)
The effect of micafungin dose scheduling on the treatment of candidemia is unknown. Neutropenic mice with disseminated Candida glabrata infection were treated with single intraperitoneal micafungin doses of 0 to 100 mg/kg of body weight and sacrifice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d258aeb98034315c11028f359f0ae8
https://pubmed.ncbi.nlm.nih.gov/17194830
https://pubmed.ncbi.nlm.nih.gov/17194830