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Autor:
Christine Falcoz, Serge Guzy, Jana Kovač, Isabel Meister, Jean Coulibaly, Somphou Sayasone, David Wesche, Yu-Wei Lin, Jennifer Keiser
Publikováno v:
Journal of pharmacokinetics and pharmacodynamics. 49(3)
Racemic praziquantel (PZQ) is the standard treatment for schistosomiasis and liver fluke infections (opisthorchiasis and clonorchiasis). The development of an optimal pediatric formulation and dose selection would benefit from a population pharmacoki
Autor:
Christine Falcoz, Serge Guzy, Jana Kovač, Isabel Meister, Jean Coulibaly, Somphou Sayasone, David Wesche, Yu-Wei Lin, Jennifer Keiser
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 49:395-395
Autor:
Jean T. Coulibaly, Isabel Meister, Jana Kovač, Christine Falcoz, Jennifer Keiser, Anna Neodo, Gordana Panic
Publikováno v:
Antimicrobial agents and chemotherapy. 62(8)
There is a growing consensus to include preschool-aged children in preventive chemotherapy programs with praziquantel to improve schistosomiasis control. However, pharmacokinetic data, crucial to establish a safe and effective dose for this age group
Autor:
William T. Prince, Christine Falcoz, Scott D. Studenberg, Timothy C. Hardman, Julian Jenkins, Carole Bye, H. Fuder, Kathy B. Kenney
Publikováno v:
The Journal of Clinical Pharmacology. 42:887-898
These two Phase I, open-label, single-dose, randomized, crossoverstudies in 40 healthymale subjects investigated the pharmacokinetic and safety profiles of various formulations of the amprenavir prodrug GW433908 in the presence and absence of food co
Publikováno v:
Drug Information Journal. 35:1047-1063
Computer-assisted drug development (CADD) is a knowledge-based process that integrates newly collected information in a drug/disease-specific knowledge frame and provides a rational basis for decision making during drug development. A mathematical mo
Publikováno v:
Clinical Pharmacokinetics. 39:1-8
The aim of this analysis was to assess the rate and extent of systemic availability of inhaled fluticasone propionate (FP) from 2 dry powder systems (Diskhaler and Diskus) and a metered-dose inhaler (MDI) by deconvolution analysis.The inhalation devi
Autor:
Alan Bye, Jo E. McDowall, Pietro Ventresca, Christine Falcoz, Ruth Oliver, Peter T. Daley-Yates
Publikováno v:
Clinical Pharmacokinetics. 39:9-15
The aim of this study was to determine the absolute oral bioavailability of fluticasone propionate (FP) in healthy volunteers.A 3-period incomplete block crossover design was used. On separate occasions, 21 male volunteers received a single 250 micro
Autor:
Christine Falcoz, M. Wagner, Heike Weisser, Jürgen Barth, Michael Krieg, Ricarda Stöckmann, Hartmut Derendorf, Helmut Möllmann, Günther Hochhaus, Bernd Meibohm
Publikováno v:
European Journal of Clinical Pharmacology. 53:459-467
To evaluate the pharmacokinetic and systemic pharmacodynamic properties of inhaled fluticasone propionate (FP).Single doses of 0.25, 0.5, 1.0 and 3.0 mg FP were administered to groups of six healthy subjects. Serum concentration profiles of FP were m
Autor:
Ricarda Stöckmann, Helmut Möllmann, Christine Falcoz, Caroline Lawlor, Yufei Tang, Michael Krieg, Hartmut Derendorf, Hristina Dimova, Günther Hochhaus, Sriram Krishnaswami, Jürgen Barth, Peter T. Daley-Yates, A.C. Möllmann, M. Wagner
Publikováno v:
Journal of clinical pharmacology. 41(12)
Direct comparisons of the pharmacokinetic (PK) and systemic pharmacodynamic (PD) properties of inhaled corticosteroids after single and multiple dosing in the same subjects are scarce. The objective of this study was to compare thePK/PDproperties of