Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Christine Espiritu"'
Autor:
Lindsey G. DeRatt, Bart Stoops, Paul Shaffer, Angela M. Lam, Christine Espiritu, Robert Vogel, Vincent Lau, Osvaldo A. Flores, Scott D. Kuduk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be8563853e1080a3605e868030d58bb
https://doi.org/10.2139/ssrn.4437984
https://doi.org/10.2139/ssrn.4437984
Autor:
Scott D. Kuduk, Lindsey G. DeRatt, Bart Stoops, Paul Shaffer, Angela M. Lam, Christine Espiritu, Robert Vogel, Vincent Lau, Osvaldo A. Flores, George D. Hartman
Publikováno v:
Bioorganicmedicinal chemistry letters. 72
The HBV capsid core protein serves a number of important functions in the viral life cycle enabling chronic HBV infection to persist, and therefore is a promising drug target. Interfering with capsid assembly has shown efficacy in clinical trials wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec63428738a7d2b18279c29d843bf0c8
https://pubmed.ncbi.nlm.nih.gov/35644301
https://pubmed.ncbi.nlm.nih.gov/35644301
Autor:
Scott D. Kuduk, Vincent Lau, Osvaldo Flores, Christine Espiritu, Robert Vogel, Angela M. Lam, George D. Hartman, Klaus Klumpp
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2405-2409
The HBV core protein has multiple essential functions in the HBV life cycle to enable chronic HBV infection. The core protein oligomerizes to form the viral capsid, and modulation of the HBV capsid assembly process has shown clinical efficacy in earl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2146095186499eb78cb90423f3a153b7
https://doi.org/10.1016/j.bmcl.2019.05.029
https://doi.org/10.1016/j.bmcl.2019.05.029
Publikováno v:
ACS Med Chem Lett
[Image: see text] Herein is reported a novel screening paradigm PURE (P450s under restriction) for the identification and optimization of hits as part of a hepatitis B virus (HBV) antiviral discovery program. To closely represent in vivo hepatocytes,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0176ff0b5305bc6336491bfd4cff5a59
https://europepmc.org/articles/PMC7549254/
https://europepmc.org/articles/PMC7549254/
Autor:
Scott D. Kuduk, Vincent Lau, Mollie Kelly, Suping Ren, Robert Vogel, Klaus Klumpp, Osvaldo Flores, Christine Espiritu, George D. Hartman, Angela M. Lam
Publikováno v:
Antimicrobial Agents and Chemotherapy
NVR 3-778 is the first capsid assembly modulator (CAM) that has demonstrated antiviral activity in hepatitis B virus (HBV)-infected patients. NVR 3-778 inhibited the generation of infectious HBV DNA-containing virus particles with a mean antiviral 50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b2c8a417236d3d07631a54c8201b55b
https://doi.org/10.1128/aac.01734-18
https://doi.org/10.1128/aac.01734-18
Autor:
Klaus Klumpp, Scott D. Kuduk, Robert Vogel, Vincent Lau, Richard Alexander, Christine Espiritu, Angela M. Lam, Bart Stoops, Osvaldo Flores, George D. Hartman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 39:127848
The HBV core protein is a druggable target of interest due to the multiple essential functions in the HBV life cycle to enable chronic HBV infection. The core protein oligomerizes to form the viral capsid, and modulation of the HBV capsid assembly ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::031ea1b6cab6d5d83c0f537e0367c5d4
https://doi.org/10.1016/j.bmcl.2021.127848
https://doi.org/10.1016/j.bmcl.2021.127848
Autor:
Charles M. Rice, Andrea D. Branch, Jose M. Silva, Ursula Andreo, Christine Espiritu, Hyo-Young Chung, Mohsan Saeed
Publikováno v:
Nature
Since its discovery in 1989, efforts to grow clinical isolates of the hepatitis C virus (HCV) in cell culture have met with limited success. Only the JFH-1 isolate has the capacity to replicate efficiently in cultured hepatoma cells without cell cult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7881b8c95cef06841cae511379b966b5
https://doi.org/10.1038/nature14899
https://doi.org/10.1038/nature14899
Autor:
Mollie Kelly, Suping Ren, Osvaldo Flores, Klaus Klumpp, Angela M. Lam, Lingjie Zheng, George D. Hartman, Vincent Lau, Christine Espiritu
Publikováno v:
Antimicrobial Agents and Chemotherapy
The hepatitis B virus (HBV) core protein serves multiple essential functions in the viral life cycle, and antiviral agents that target the core protein are being developed. Capsid assembly modulators (CAMs) are compounds that target core and misdirec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1585dfa7abeee3ad72db09e47be642f7
http://europepmc.org/articles/PMC5527605
http://europepmc.org/articles/PMC5527605
Autor:
Yalei Liu, Valerie Clausen, Amin A. Nomeir, Xiaoyan Zhang, Christie Morrill, William Joseph Lennox, Anthony Turpoff, Zhengxian Gu, Takashi Komatsu, Christine Espiritu, Neil Gregory Almstead, F. George Njoroge, Gary Mitchell Karp, Guangming Chen, Steven D. Paget, Joseph M. Colacino, Hongyu Ren, Chunshi Li, Jin Zhu, Jason D. Graci, Nanjing Zhang, Nicole Risher, Frederick C. Lahser, Marla Weetall, James J. Takasugi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3947-3953
A novel series of 6-(indol-2-yl)pyridine-3-sulfonamides was prepared and evaluated for their ability to inhibit HCV RNA replication in the HCV replicon cell culture assay. Preliminary optimization of this series furnished compounds with low nanomolar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7637387fd6f4b0f3d5c90b600082ee8
https://doi.org/10.1016/j.bmcl.2013.04.049
https://doi.org/10.1016/j.bmcl.2013.04.049
Autor:
Hamsika Chandrasekar, Sangeeta N. Bhatia, Robert E. Schwartz, Timothy P. Sheahan, Mei Lyn Ong, Alexander van Oudenaarden, Kartik Trehan, Christine Espiritu, Kathleen Christine, Vyas Ramanan, Hans Heinrich Hoffmann, Charles M. Rice, Joseph M. Luna
Publikováno v:
PMC
Virology, 494, 236. Academic Press Inc.
Virology, 494, 236-47. Academic Press
Virology, 494, 236. Academic Press Inc.
Virology, 494, 236-47. Academic Press
Hepatitis C virus (HCV) is a positive single-stranded RNA virus of enormous global health importance, with direct-acting antiviral therapies replacing an immunostimulatory interferon-based regimen. The dynamics of HCV positive and negative-strand vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::241b28eef4ffa3f80720396ccfea8021
https://orcid.org/0000-0001-6214-4788
https://orcid.org/0000-0001-6214-4788