Hyaluronan-CD44 interaction promotes HPV 16 E6 oncogene-mediated oropharyngeal cell carcinoma survival and chemoresistance

Autor: Lilly Y.W. Bourguignon, Christine Earle, Marisa Shiina

Publikováno v: Matrix biology : journal of the International Society for Matrix Biology.

Head and neck squamous cell carcinoma (HNSCC) is a malignancy that often involves the oral cavity, pharynx, larynx, or paranasal sinuses. There is a compelling evidence of the human papilloma virus including HPV16 E6 oncogene drives cell transformati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::736be7f590d3f8c9ed9079be3b3eace3
https://pubmed.ncbi.nlm.nih.gov/30077625

Interaction of low molecular weight hyaluronan with CD44 and toll-like receptors promotes the actin filament-associated protein 110-actin binding and MyD88-NFκB signaling leading to proinflammatory cytokine/chemokine production and breast tumor invasion

Autor: Christine Earle, Gabriel Wong, Lilly Y.W. Bourguignon, Weiliang Xia

Publikováno v: Cytoskeleton. 68:671-693

Both high and low molecular weight hyaluronan (HMW-HA vs. LMW-HA) exist in various tissues and cells. In this study, we investigated LMW-HA-mediated CD44 interaction with Toll-like receptors (TLRs), the actin filament-associated protein (AFAP-110), a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8fcdc7f5bb3e5fc4dd7e77cbddc064e
https://doi.org/10.1002/cm.20544

Hyaluronan-CD44 Interaction Promotes c-Src-mediated Twist Signaling, MicroRNA-10b Expression, and RhoA/RhoC Up-regulation, Leading to Rho-kinase-associated Cytoskeleton Activation and Breast Tumor Cell Invasion

Autor: Lilly Y.W. Bourguignon, Gabriel Wong, Katherine C. Krueger, Christine Earle, Christina C. Spevak

Publikováno v: Journal of Biological Chemistry. 285:36721-36735

Dysregulation of microRNAs is observed in many cancers, including breast cancer. In particular, miR-10b appears to play an important role in tumor cell invasion and breast cancer progression. In this study, we investigated hyaluronan (HA)-induced CD4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad265e1ef04cadd9d5283943ca380f2
https://doi.org/10.1074/jbc.m110.162305

Activation of Matrix Hyaluronan-Mediated CD44 Signaling, Epigenetic Regulation and Chemoresistance in Head and Neck Cancer Stem Cells

Autor: Christine Earle, Marisa Shiina, Lilly Y.W. Bourguignon

Publikováno v: International Journal of Molecular Sciences, Vol 18, Iss 9, p 1849 (2017)
International Journal of Molecular Sciences
International journal of molecular sciences, vol 18, iss 9

Head and neck squamous cell carcinoma (HNSCC) is a solid tumor composed by a genotypically and phenotypically heterogeneous population of neoplastic cells types. High recurrence rate and regional metastases lead to major morbidity and mortality. Rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150582658975596372f79177f7368646
https://doi.org/10.3390/ijms18091849

Hyaluronan-CD44v3 Interaction with Oct4-Sox2-Nanog Promotes miR-302 Expression Leading to Self-renewal, Clonal Formation, and Cisplatin Resistance in Cancer Stem Cells from Head and Neck Squamous Cell Carcinoma*

Autor: Gabriel Wong, Lilly Y.W. Bourguignon, Liqun Chen, Christine Earle

Publikováno v: The Journal of biological chemistry, vol 287, iss 39

Human head and neck squamous cell carcinoma (HNSCC) is a highly malignant cancer associated with major morbidity and mortality. In this study, we determined that human HNSCC-derived HSC-3 cells contain a subpopulation of cancer stem cells (CSCs) char

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a704cbe83890016befff275671553de3
https://europepmc.org/articles/PMC3463333/