Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Christine E. Tinberg"'
Autor:
Riti Biswas, Ed Belouski, Kevin Graham, Michelle Hortter, Marissa Mock, Christine E. Tinberg, Alan J. Russell
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTWe are entering an era in which therapeutic proteins are assembled using building block-like strategies, with no standardized schema to discuss these formats. Existing nomenclatures, like AbML, sacrifice human readability for precision. There
Externí odkaz:
https://doaj.org/article/a742f5fea5fa4f1dba7e11771a364ca2
Autor:
Ameya Harmalkar, Roshan Rao, Yuxuan Richard Xie, Jonas Honer, Wibke Deisting, Jonas Anlahr, Anja Hoenig, Julia Czwikla, Eva Sienz-Widmann, Doris Rau, Austin J. Rice, Timothy P. Riley, Danqing Li, Hannah B. Catterall, Christine E. Tinberg, Jeffrey J. Gray, Kathy Y. Wei
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTOver the last three decades, the appeal for monoclonal antibodies (mAbs) as therapeutics has been steadily increasing as evident with FDA’s recent landmark approval of the 100th mAb. Unlike mAbs that bind to single targets, multispecific bi
Externí odkaz:
https://doaj.org/article/f28435022c594bb495320039c11e0b93
Autor:
Sumedha Roy, Karen Fitzgerald, Almin Lalani, Chin-Wen Lai, Aeryon Kim, Jennie Kim, Peiqi Ou, Annie Mirsoian, Xian Liu, Ambika Ramrakhiani, Huiren Zhao, Hong Zhou, Haoda Xu, Hans Meisen, Chi-Ming Li, Bryan Vander Lugt, Steve Thibault, Christine E. Tinberg, Jason DeVoss, Jackson Egen, Lawren C. Wu, Rajkumar Noubade
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 12 (2023)
While the rapid advancement of immunotherapies has revolutionized cancer treatment, only a small fraction of patients derive clinical benefit. Eradication of large, established tumors appears to depend on engaging and activating both innate and adapt
Externí odkaz:
https://doaj.org/article/d95e2a61244d4914a737061907108286
Autor:
Ameya Harmalkar, Roshan Rao, Jonas Honer, Wibke Deisting, Jonas Anlahr, Anja Hoenig, Julia Czwikla, Eva Sienz-Widmann, Doris Rau, Austin Rice, Timothy P. Riley, Danqing Li, Hannah B. Catterall, Christine E. Tinberg, Jeffrey J. Gray, Kathy Y. Wei
Over the last three decades, the appeal for monoclonal antibodies (mAbs) as therapeutics has been steadily increasing as evident with FDA’s recent landmark approval of the 100th mAb. Unlike mAbs that bind to single targets, multispecific biologics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b3aad643c74f4e957cce72de0e34d15
https://doi.org/10.1101/2022.06.03.494724
https://doi.org/10.1101/2022.06.03.494724
Autor:
Justin Feng, Benjamin W Jester, Christine E Tinberg, Daniel J Mandell, Mauricio S Antunes, Raj Chari, Kevin J Morey, Xavier Rios, June I Medford, George M Church, Stanley Fields, David Baker
Publikováno v:
eLife, Vol 4 (2015)
Biosensors for small molecules can be used in applications that range from metabolic engineering to orthogonal control of transcription. Here, we produce biosensors based on a ligand-binding domain (LBD) by using a method that, in principle, can be a
Externí odkaz:
https://doaj.org/article/e23b7635567844d98bb67dbfb1f20994
Publikováno v:
ACS Synthetic Biology. 7:2457-2467
Biosensors are important components of many synthetic biology and metabolic engineering applications. Here, we report a second generation of Saccharomyces cerevisiae digoxigenin and progesterone biosensors based on destabilized dimeric ligand-binding
Autor:
James B. Dunbar, Heather A. Carlson, Ginger Kubish, Sagar D. Khare, Jeanne A. Stuckey, Krishnapriya Chinnaswamy, Kelly L. Damm-Ganamet, David Baker, Jiayi Dou, James Delproposto, Christine E. Tinberg, Lindsey Doyle, Aqeel Ahmed, Richard D. Smith
Publikováno v:
Journal of Chemical Information and Modeling. 56:1022-1031
The Community Structure Activity Resource (CSAR) conducted a benchmark exercise to evaluate the current computational methods for protein design, ligand docking, and scoring/ranking. The exercise consisted of three phases. The first phase required th
Autor:
William J. Van Patten, Rashmi Ravichandran, Christine E. Tinberg, Thomas T. Perkins, Ayush Adhikari, Stephen R. Okoniewski, Robert Walder, David Baker
Publikováno v:
Chemphyschem : a European journal of chemical physics and physical chemistry. 19(1)
Quantifying the energy landscape underlying protein-ligand interactions leads to an enhanced understanding of molecular recognition. A powerful yet accessible single-molecule technique is atomic force microscopy (AFM)-based force spectroscopy, which
Autor:
Aaron A. Nazarian, Haruki Hasegawa, Karen Siegler, Christine E. Tinberg, Mei-Mei Tsai, Ann Hsu
Publikováno v:
mAbs. 9(5)
Amino acid sequence differences in the variable region of immunoglobulin (Ig) cause wide variations in secretion outputs. To address how a primary sequence difference comes to modulate Ig secretion, we investigated the biosynthetic process of 2 human
Autor:
Christine E, Tinberg, Sagar D, Khare
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1529
The ability to design novel small-molecule binding sites in proteins is a stringent test of our understanding of the principles of molecular recognition, and would have many practical applications, in synthetic biology and medicine. Here, we describe