Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Christine E. Prosser"'
Autor:
Christian Ottmann, Christine E. Prosser, Alice Ballone, Francesca Picarazzi, Mattia Mori, Jeremy Martin Davis
Publikováno v:
Journal of Chemical Information and Modeling, 60(12). American Chemical Society
The exploration of the druggability of certain protein-protein interactions (PPIs) still remains a challenging task in drug discovery. Here, we present a case study using the 14-3-3-PPI, showing how small molecules can be located that are able to mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdb0cb464e91f1c0f188b40a060f4ec3
https://doi.org/10.1021/acs.jcim.0c00722
https://doi.org/10.1021/acs.jcim.0c00722
Autor:
Richard J. K. Taylor, Mark D. Carr, Sarah L. Strong, Alistair James Henry, Vaclav Veverka, Frederick W. Muskett, Christine E. Prosser, Alastair D. G. Lawson, Lorna C. Waters, Neesha Dedi
Publikováno v:
Cytokine. 142
The proinflammatory cytokines IL-17A and IL-17F have been identified as key drivers of a range of human inflammatory diseases, such as psoriasis, which has led to several therapeutic antibodies targeted at IL-17A. The two cytokines have been shown to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed0c7804fde5d7886fc531c9469bb750
https://pubmed.ncbi.nlm.nih.gov/33706174
https://pubmed.ncbi.nlm.nih.gov/33706174
Autor:
Vaclav Veverka, Christine E. Prosser, Lorna C. Waters, Mark D. Carr, Ian C. Wilkinson, Alistair James Henry, Shaun Bruton, Frederick W. Muskett, Philip W. Addis, Catherine J. Hall, Richard J. K. Taylor, Bruce Carrington, Alastair D. G. Lawson, Robert G. Griffin, Philip S. Renshaw
Publikováno v:
Journal of Biological Chemistry. 289:7200-7210
Specific, high affinity protein-protein interactions lie at the heart of many essential biological processes, including the recognition of an apparently limitless range of foreign proteins by natural antibodies, which has been exploited to develop th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d241c2a3777d5638bfc84b10d0539a8
https://doi.org/10.1074/jbc.m113.492215
https://doi.org/10.1074/jbc.m113.492215
Autor:
Matthew P. Crump, Harry Mackenzie, Christine E. Prosser, Adam Hold, John Crosby, Daniel James Ford, John Robert Porter, Ian Whitcombe, Richard J. K. Taylor, Rachel A. Garlish, Hannah J. Maple
Publikováno v:
Analytical Chemistry. 85:5958-5964
Atropisomerism of pharmaceutical compounds is a challenging area for drug discovery programs (Angew. Chem., Int. Ed. 2009, 48, 6398-6401). Strategies for dealing with these compounds include raising the energy barrier to atropisomerization in order t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a50540ddc595d11014f0fa978c95838f
https://doi.org/10.1021/ac400760p
https://doi.org/10.1021/ac400760p
Autor:
Christine E, Prosser, Lorna C, Waters, Frederick W, Muskett, Vaclav, Veverka, Philip W, Addis, Laura M, Griffin, Terry S, Baker, Alastair D G, Lawson, Ulrich, Wernery, Jorg, Kinne, Alistair J, Henry, Richard J, Taylor, Mark D, Carr
Publikováno v:
Biomolecular NMR assignments. 8(1)
Heavy chain antibodies differ in structure to conventional antibodies lacking both the light chain and the first heavy chain constant domain (CH1). Characteristics of the antigen-binding variable heavy domain of the heavy chain antibody (VHH) includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f4e966baaf6ccbf1dc09b9bab89f9aaa
https://pubmed.ncbi.nlm.nih.gov/23359223
https://pubmed.ncbi.nlm.nih.gov/23359223
Autor:
John Robert Porter, Richard J. K. Taylor, John Crosby, Matthew P. Crump, Rachel A. Garlish, Hannah J. Maple, Christine E. Prosser, Alistair James Henry, Jeff Kennedy, Ian Whitcombe, Laura Rigau-Roca
Publikováno v:
Journal of medicinal chemistry. 55(2)
Identifying protein-ligand binding interactions is a key step during early-stage drug discovery. Existing screening techniques are often associated with drawbacks such as low throughput, high sample consumption, and dynamic range limitations. The inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f71f6a302defb2bce662b9a633e88fda
https://pubmed.ncbi.nlm.nih.gov/22148839
https://pubmed.ncbi.nlm.nih.gov/22148839