Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Christine E. Peters"'
Autor:
Christine E. Peters, Ursula Schulze-Gahmen, Manon Eckhardt, Gwendolyn M. Jang, Jiewei Xu, Ernst H. Pulido, Conner Bardine, Charles S. Craik, Melanie Ott, Or Gozani, Kliment A. Verba, Ruth Hüttenhain, Jan E. Carette, Nevan J. Krogan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Actin histidine methyltransferase SETD3 is a host factor critical for the replication of enteroviruses. Here, the authors report the 3.5 Å cryoEM structure of SETD3 interacting with enterovirus CV-B3 2A protease, defining the actin-binding SET domai
Externí odkaz:
https://doaj.org/article/22221195d9174bdcb9744f12954ad8ae
Autor:
Christine E. Peters, Jan E. Carette
Publikováno v:
Viruses, Vol 13, Iss 2, p 166 (2021)
Enteroviruses are among the most common human infectious agents. While infections are often mild, the severe neuropathogenesis associated with recent outbreaks of emerging non-polio enteroviruses, such as EV-A71 and EV-D68, highlights their continuin
Externí odkaz:
https://doaj.org/article/e566012c90f04dfaa54526ede343dcae
Autor:
Christopher M. Richards, Sabrina Jabs, Wenjie Qiao, Lauren D. Varanese, Michaela Schweizer, Peter R. Mosen, Nicholas M. Riley, Malte Klüssendorf, James R. Zengel, Ryan A. Flynn, Arjun Rustagi, John C. Widen, Christine E. Peters, Yaw Shin Ooi, Xuping Xie, Pei-Yong Shi, Ralf Bartenschlager, Andreas S. Puschnik, Matthew Bogyo, Carolyn R. Bertozzi, Catherine A. Blish, Dominic Winter, Claude M. Nagamine, Thomas Braulke, Jan E. Carette
Publikováno v:
Science
Lysosomes are key degradative compartments of the cell. Transport to lysosomes relies on GlcNAc-1-phosphotransferase–mediated tagging of soluble enzymes with mannose 6-phosphate (M6P). GlcNAc-1-phosphotransferase deficiency leads to the severe lyso
Autor:
Jan E. Carette, Christine E. Peters
Publikováno v:
Viruses, Vol 13, Iss 166, p 166 (2021)
Viruses
Viruses
Enteroviruses are among the most common human infectious agents. While infections are often mild, the severe neuropathogenesis associated with recent outbreaks of emerging non-polio enteroviruses, such as EV-A71 and EV-D68, highlights their continuin
Autor:
Or Gozani, Jan E. Carette, Jeffrey R. Johnson, Peter Sarnow, Erik Verschueren, Jonathan Diep, Harry B. Greenberg, Tracy Young, Eileen Foy, Kristi J. Kobluk, James Zengel, Raul Andino, Christine E. Peters, Kuo-Feng Weng, Jiewei Xu, Alex W. Wilkinson, Ruth Hüttenhain, Siyuan Ding, Nevan J. Krogan, Gwendolyn M. Jang, Joshua E. Elias, Yaw Shin Ooi, Orly Laufman, Claude M. Nagamine
Publikováno v:
Nature microbiology, vol 4, iss 12
Nature microbiology
Nature microbiology
Enteroviruses (EVs) comprise a large genus of positive-sense, single-stranded RNA viruses whose members cause a number of important and widespread human diseases, including poliomyelitis, myocarditis, acute flaccid myelitis and the common cold. How E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73230660466375e76f25ef7276487c26
https://escholarship.org/uc/item/4xj9w0zf
https://escholarship.org/uc/item/4xj9w0zf
Autor:
Mohamed N. Seleem, Haroon Mohammad, Mohamed Hagras, Abdelrahman S. Mayhoub, Christine E. Peters, Mohamed M. Elsebaei, Kit Pogliano, Youssef A. Hegazy, Bruce A. Cooper, Hamada S. Abulkhair, Joe Pogliano, Islam Eid
Publikováno v:
European Journal of Medicinal Chemistry. 139:665-673
The promising antibacterial potency of arylthiazole antibiotics is offset by their limited activity against intracellular bacteria (namely methicillin-resistant Staphylococcus aureus (MRSA)), similar to many clinically-approved antibiotics. The failu
Publikováno v:
Nucleic Acids Research
Many bacterial adaptive responses to changes in growth conditions due to biotic and abiotic factors involve reprogramming of gene expression at the transcription level. The bacterial RNA polymerase (RNAP), which catalyzes transcription, can thus be c
Autor:
Joe Pogliano, Lauren Brumage, Anne Lamsa, Kit Pogliano, Christine E. Peters, Diana Quach, Joseph Sugie, Javier Lopez-Garrido, Roland B. Liu
Publikováno v:
ACS chemical biology. 13(12)
Understanding the mechanism of action (MOA) of new antimicrobial agents is a critical step in drug discovery but is notoriously difficult for compounds that appear to inhibit multiple cellular pathways. We recently described image-based approaches [b
Autor:
Waleed Younis, Haroon Mohammad, Bruce A. Cooper, Kit Pogliano, Joe Pogliano, Christine E. Peters, Ahmed Abdelkhalek, Hany G. Ezzat, Abdelrahman S. Mayhoub, Mohamed N. Seleem
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 8, p e0182821 (2017)
PloS one, vol 12, iss 8
PLoS ONE, Vol 12, Iss 8, p e0182821 (2017)
PloS one, vol 12, iss 8
Bacterial resistance to antibiotics remains an imposing global public health challenge. Of the most serious pathogens, methicillin-resistant Staphylococcus aureus (MRSA) is problematic given strains have emerged that exhibit resistance to several ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6109994bb796e7751729c2bb0d3fe620
https://hdl.handle.net/10919/100041
https://hdl.handle.net/10919/100041
Publikováno v:
Endocrine. 6(2)
Estrogen and progesterone replacement in ovariectomized rats in an often-used experimental system for determination of the specific effects of these hormones. In this study, two different delivery systems and two different dosage levels of estrogen,