Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Christine E. Oborski"'
Autor:
Timothy A. Subashi, Douglas S. Johnson, Christine E. Oborski, Kevin Atchison, Kathleen M. Wood, Christine P. Parker, Rathna Iyer, Bruce A. Maguire, Martin Pettersson, Kelly R. Bales, Nikolay Pozdnyakov, Gary Bora
Publikováno v:
Neuroscience and Medicine. :149-161
γ-Secretase is involved in the final processing of the amyloid precursor protein into a heterogeneous pool of β-amyloid (Aβ) peptides. Current Alzheimer’s disease drug discovery efforts include targeting γ-secretase activity in brain to attenua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60af06540d662be62708d6c734dd860c
https://doi.org/10.4236/nm.2012.32020
https://doi.org/10.4236/nm.2012.32020
Autor:
Douglas E. Wood, Robert B. Nelson, Barbara G. Sahagan, Xingrong Liu, Lei Zhang, Nikolay Pozdnyakov, Jeffrey Van Deusen, Karl E.G. Richter, James E. Finley, Christine P. Parker, Karen J. Coffman, Michael Aaron Brodney, Barbara-Anne Martin, David D. Auperin, Joel B. Schachter, Dane R. Liston, Michael J. Karmilowicz, Tracy M. Brown, Barbara Tate, Christine E. Oborski, Sharon A. Sokolowski, Stacey L. Becker, Bronk Brian Scott, Thomas A. Lanz, Carol D. Hicks, Charles E. Nolan, Kathleen M. Wood
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2637-2640
A novel series of tetralin containing amino imidazoles, derived from modification of the corresponding phenyl acetic acid derivatives is described. Replacement of the amide led to identification of a potent series of tetralin-amino imidazoles with ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecedc3d6dd0ae90f3f64245736a002bc
https://doi.org/10.1016/j.bmcl.2010.12.118
https://doi.org/10.1016/j.bmcl.2010.12.118
Autor:
Kathleen M. Wood, Ping Du, Karen J. Coffman, Karl E.G. Richter, Sharon A. Sokolowski, Barbara-Anne Martin, Dane R. Liston, Barbara Tate, Douglas E. Wood, Tracy M. Brown, Michael Aaron Brodney, Carol D. Hicks, Charles E. Nolan, Nikolay Pozdnyakov, James E. Finley, Christine E. Oborski, Stacey L. Becker, Thomas A. Lanz, Kieran F. Geoghegan
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 334:269-277
PF-3084014 [(S)-2-((S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-3-ylamino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide] is a novel gamma-secretase inhibitor that reduces amyloid-beta (Abeta) production with an in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe3da18b952deeed900e3aece6d23d62
https://doi.org/10.1124/jpet.110.167379
https://doi.org/10.1124/jpet.110.167379
Autor:
Claude Ambroise, Matthew F. Calabrese, David Riddell, Stephen Noell, Christine E. Oborski, Warren D. Hirst, Zdenek Berger, Sarah Perkins
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 3, p e0119141 (2015)
PLoS ONE, Vol 10, Iss 3, p e0119141 (2015)
Mutations in glucocerebrosidase (GBA1) cause Gaucher disease and also represent a common risk factor for Parkinson’s disease and Dementia with Lewy bodies. Recently, new tool molecules were described which can increase turnover of an artificial sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9290310ed676a796d82029d152eb46e
http://europepmc.org/articles/PMC4357465
http://europepmc.org/articles/PMC4357465
Autor:
Yasong Lu, Liming Zhang, David Riddell, Cathleen Gonzales, Antonia F. Stepan, Michael Aaron Brodney, Stephen Noell, Leslie R. Pustilnik, Charles E. Nolan, Eva Hajos-Korcsok, Christine E. Oborski, Kevin Atchison, Ivan Viktorovich Efremov, Claude Ambroise, Ashley Robshaw, Chakrapani Subramanyam
Publikováno v:
Alzheimer's & Dementia. 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adea9195a6e959c02150f073988a9f43
https://doi.org/10.1016/j.jalz.2013.05.1671
https://doi.org/10.1016/j.jalz.2013.05.1671
Autor:
Michael Aaron Brodney, Kevin Atchison, Yao Zhang, Cheng Chang, Leslie R. Pustilnik, Yasong Lu, Sandra J. Engle, Stephen Noell, Kewa Mou, Ashley Robshaw, David Riddell, Charles E. Nolan, Christine E. Oborski
Publikováno v:
Alzheimer's & Dementia. 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c91a0ff3e15138253e122a11041c4a0
https://doi.org/10.1016/j.jalz.2013.05.1684
https://doi.org/10.1016/j.jalz.2013.05.1684
Autor:
Andre Negahban, Kevin Atchison, Stephen Noell, Cathleen Gonzales, David Riddell, Leslie R. Pustilnik, Christopher Ryan Butler, Brian T. O’Neill, Cheng Chang, Shawn D. Doran, Feng Pan, Yasong Lu, Elizabeth Mary Beck, Jianhua Liu, Ashley Robshaw, Charles E. Nolan, Christine E. Oborski, Michael Aaron Brodney, Claude Ambroise, Eva Hajos-Korcsok
Publikováno v:
Alzheimer's & Dementia. 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::763cd00940c0fd892ea9ab25dc1a4772
https://doi.org/10.1016/j.jalz.2013.05.1670
https://doi.org/10.1016/j.jalz.2013.05.1670
Autor:
ONeill Brian, Claude Ambroise, Michael Aaron Brodney, Christine E. Oborski, Kevin Atchison, David Riddell, Stephen Noell, Charles E. Nolan, Leslie R. Pustilnik
Publikováno v:
Alzheimer's & Dementia. 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1061963399b2c50e860667de488c88f0
https://doi.org/10.1016/j.jalz.2013.05.331
https://doi.org/10.1016/j.jalz.2013.05.331
Autor:
Jane M. Withka, Ivan Viktorovich Efremov, Jianhua Liu, Alison H. Varghese, Felix Vajdos, Kevin Ogilvie, Kris A. Borzilleri, Michael Aaron Brodney, Claude Ambroise, Gabriela Barreiro, Eva Hajos-Korcsok, Lorraine F. Lanyon, Curt Christoffersen, Christine E. Oborski, Katherine Fisher, Charles E. Nolan, John C. Murray, Brian T. O’Neill
Publikováno v:
Journal of medicinal chemistry. 55(21)
β-Secretase 1 (BACE-1) is an attractive therapeutic target for the treatment and prevention of Alzheimer's disease (AD). Herein, we describe the discovery of a novel class of BACE-1 inhibitors represented by sulfamide 14g, using a medicinal chemistr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e84a213ae48ca19911847d13d96e34f1
https://pubmed.ncbi.nlm.nih.gov/22984865
https://pubmed.ncbi.nlm.nih.gov/22984865
Autor:
Jason K. Dutra, Jayvardhan Pandit, Hong Wang, Mahmoud N. Mansour, Christine E. Oborski, Binqing Wei, Alexander S. McColl, Theresa J. O’Sullivan, Steven W. Goldstein, Steven Capetta, Stephen Noell, Jane M. Withka, Dorff Peter H, Hou Chen, Thomas N. O'Connell, Felix Vajdos, Ivan Viktorovich Efremov, Kris A. Borzilleri
Publikováno v:
Journal of medicinal chemistry. 55(21)
The aspartyl protease β-secretase, or BACE, has been demonstrated to be a key factor in the proteolytic formation of Aβ-peptide, a major component of plaques in the brains of Alzheimer’s disease (AD) patients, and inhibition of this enzyme has em
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30cdb9cd7c0141ab1f9f362154dc8116
https://pubmed.ncbi.nlm.nih.gov/22468999
https://pubmed.ncbi.nlm.nih.gov/22468999