Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christine E. Kaiser"'
Publikováno v:
Acta Crystallographica Section E, Vol 67, Iss 1, Pp o23-o24 (2011)
There are two crystallographically unique molecules present in the asymmetric unit of the title compound, C14H16N6O; in both molecules, the seven-membered diazepinone ring adopts a boat-like conformation and the chair conformation piperidine ring is
Externí odkaz:
https://doaj.org/article/35e2cc090e1f4734bb72d1b26fc76aea
Autor:
Prashansa Agrawal, Laurence H. Hurley, Reena Chawla, Natalie A. Van Ert, Christine E. Kaiser, Danzhou Yang
Publikováno v:
Journal of the American Chemical Society. 139:8522-8536
Activating KRAS mutations frequently occur in pancreatic, colorectal, and lung adenocarcinomas. While many attempts have been made to target oncogenic KRAS, no clinically useful therapies currently exist. Most efforts to target KRAS have focused on i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928d244ab2a33e33414d2f580c5c29e6
https://doi.org/10.1021/jacs.7b02046
https://doi.org/10.1021/jacs.7b02046
Autor:
David D. Weis, Jittasak Khowsathit, Andrew X. Zhang, John Karanicolas, M. Paola Castaldi, Christine E. Kaiser, Steven L. Kazmirski, Juan Pablo Rincon Pabon
Publikováno v:
ACS synthetic biology. 7(4)
Monoclonal antibody therapeutics have revolutionized the treatment of diseases such as cancer and autoimmune disorders, and also serve as research reagents for diverse and unparalleled applications. To extend their utility in both contexts, we have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea1f4bbaa1d4ff26c0a21234dfe354a
https://pubmed.ncbi.nlm.nih.gov/29609459
https://pubmed.ncbi.nlm.nih.gov/29609459
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:5343-5351
In order to improve the discovery and development of new drugs, a broad effort is being made to assess the 'drug-like' properties of molecules in early stages of the discovery-research process. Although there are numerous approaches to this problem,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::018ab50d45c432ea5d1e520435880b32
https://doi.org/10.1016/j.bmc.2011.11.064
https://doi.org/10.1016/j.bmc.2011.11.064
Autor:
Nina M. Patrick, Muhammad Ayaz, Fabio De Moliner, Christine E. Kaiser, Christopher Hulme, Brendan Frett, Zhi-Gang Xu, Steven Gunawan
Publikováno v:
Tetrahedron. 68:5606-5611
A two-step strategy for the synthesis of arrays of tricyclic tetrazolo-fused benzodiazepines and benzodiazepinones has been investigated. The protocol uses ortho-N-Boc phenylisocyanides and phenylglyoxaldehydes or ethyl glyoxylate in the four-compone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::213be10fad04043e7ca78d4c1c095acd
https://doi.org/10.1016/j.tet.2012.04.068
https://doi.org/10.1016/j.tet.2012.04.068
Publikováno v:
Tetrahedron Letters. 51:3951-3955
Novel two-step solution phase protocols for the synthesis of dihydroquinazolines and fused dihydroquinazoline-benzodiazepine tetracycles are reported. The methodology employs the Ugi reaction to assemble the desired diversity and acid treatment enabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bd5b6d3791483ad25b72b1e7b2407e1
https://doi.org/10.1016/j.tetlet.2010.05.108
https://doi.org/10.1016/j.tetlet.2010.05.108
Autor:
Muhammad Ayaz, Christopher Hulme, Brendan Frett, Fabio De Moliner, Steven Gunawan, Nina M. Patrick, Zhi-Gang Xu, Christine E. Kaiser
Publikováno v:
ChemInform. 43
A two-step strategy for the synthesis of arrays of tricyclic tetrazolo-fused benzodiazepines and benzodiazepinones has been investigated. The protocol uses ortho-N-Boc phenylisocyanides and phenylglyoxaldehydes or ethyl glyoxylate in the four-compone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6b4654be5a455e95acaad7246884ea9
https://doi.org/10.1002/chin.201249188
https://doi.org/10.1002/chin.201249188
Publikováno v:
ChemInform. 41
Ugi four-component reaction of mono N-Boc protected o-aminobenzylamines such as (I) and following acid catalyzed dehydrative cyclization offers a simple route to different types of pharmaceutically important title scaffolds.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a7bbcbd6f9ee5db8a0553e82bc57f6a
https://doi.org/10.1002/chin.201045167
https://doi.org/10.1002/chin.201045167
Publikováno v:
Acta Crystallographica Section E, Vol 67, Iss 1, Pp o23-o24 (2011)
Acta Crystallographica Section E: Structure Reports
Acta Crystallographica Section E: Structure Reports
There are two crystallographically unique molecules present in the asymmetric unit of the title compound, C14H16N6O; in both molecules, the seven-membered diazepinone ring adopts a boat-like conformation and the chair conformation piperidine ring is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d3564499760f4129fa68914ced6fbc4
https://doi.org/10.1107/s1600536810049950
https://doi.org/10.1107/s1600536810049950
Publikováno v:
Cancer Research. 72:1829-1829
kRAS is one of, if not the, most prevalent oncogenic aberrations identified to date. It is either upregulated or mutationally activated in a multitude of cancers, including close to 100% of pancreatic adenocarcinomas. Pancreatic cancer carries the hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c52f8f2612562c8782944cc84567f99
https://doi.org/10.1158/1538-7445.am2012-1829
https://doi.org/10.1158/1538-7445.am2012-1829