Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Christine E. Dawe"'
Publikováno v:
Journal of Molecular Biology. 415:793-806
The regulation of nucleosome positioning and composition by ATP-dependent chromatin remodeling enzymes and their associated binding partners plays important biological roles in mammals. CECR2 is a binding partner to the ISWI (imitation switch) ATPase
Autor:
Christine E. Dawe, Heather E. McDermid, Megan K. Kooistra, Amanda C. Pisio, Nicholas A. Fairbridge
Publikováno v:
Developmental Dynamics. 240:372-383
The loss of Cecr2, which encodes a chromatin remodeling protein, has been associated with the neural tube defect (NTD) exencephaly and open eyelids in mice. Here, we show that two independent mutations of Cecr2 are also associated with specific inner
Autor:
Heather E. McDermid, Kirst King-Jones, Farshad H. Niri, Christine E. Dawe, Nicholas A. Fairbridge, Megan K. Kooistra
Publikováno v:
Birth Defects Research Part A: Clinical and Molecular Teratology. 88:619-625
BACKGROUND: Over 200 mouse genes are associated with neural tube defects (NTDs), including Cecr2, the bromodomain-containing subunit of the CERF chromatin remodeling complex. METHODS: Gene-trap mutation Cecr2Gt45Bic results in 74% exencephaly (equiva
Autor:
Christine E. Dawe, Diana M. Juriloff, Megan K. Kooistra, Renee Y.M. Leduc, Mattea Bujold, Nicholas A. Fairbridge, Jay Rasmussen, Kirst King-Jones, Julie H.Y. Man, Heather E. McDermid
Publikováno v:
Physiological genomics. 44(1)
Although neural tube defects (NTDs) are common in humans, little is known about their multifactorial genetic causes. While most mouse models involve NTDs caused by a single mutated gene, we have previously described a multigenic system involving susc