KAT5 regulates neurodevelopmental states associated with G0-like populations in glioblastoma

Autor: Anca B. Mihalas, Sonali Arora, Samantha A. O’Connor, Heather M. Feldman, Christine E. Cucinotta, Kelly Mitchell, John Bassett, Dayoung Kim, Kang Jin, Pia Hoellerbauer, Jennifer Delegard, Melissa Ling, Wesley Jenkins, Megan Kufeld, Philip Corrin, Lucas Carter, Toshio Tsukiyama, Bruce Aronow, Christopher L. Plaisier, Anoop P. Patel, Patrick J. Paddison

SummaryIn solid tumors, G0-like states are likely critical for maintaining developmental hierarchies and cellular heterogeneity and promoting tumor growth/recurrence, yet little is known about tumor G0 states or regulation of their ingress/egress. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14778bacdf0e8de36e3edf2cc4ee8eab
https://doi.org/10.1101/2022.03.17.484768

The Nucleosome Acidic Patch Regulates the H2B K123 Monoubiquitylation Cascade and Transcription Elongation in Saccharomyces cerevisiae.

Autor: Christine E Cucinotta, Alexandria N Young, Kristin M Klucevsek, Karen M Arndt

Publikováno v: PLoS Genetics, Vol 11, Iss 8, p e1005420 (2015)

Eukaryotes regulate gene expression and other nuclear processes through the posttranslational modification of histones. In S. cerevisiae, the mono-ubiquitylation of histone H2B on lysine 123 (H2B K123ub) affects nucleosome stability, broadly influenc

Externí odkaz: https://doaj.org/article/810bab1a28e343588c9baacc0cc29472

Strength is in engagement: The rise of an online scientific community during the COVID-19 pandemic

Autor: Christine E. Cucinotta, Melvin Noe Gonzalez, Vladimir B. Teif, Pravrutha Raman, Hanneke Vlaming, Benjamin J. E. Martin

Publikováno v: Cucinotta, C E, Martin, B J E, Noé González, M, Raman, P, Teif, V B & Vlaming, H 2021, ' Strength is in engagement : The rise of an online scientific community during the COVID-19 pandemic ', EMBO Reports, vol. 22, no. 5, e52612 . https://doi.org/10.15252/embr.202152612

Many scientists, confined to home office by COVID-19, have been gathering in online communities, which could become viable alternatives to physical meetings and conferences.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48e0ea136c309e73860a5b289f2a9a1
https://pubmed.ncbi.nlm.nih.gov/33949091

The nucleosome acidic patch directly interacts with subunits of the Paf1 and FACT complexes and controls chromatin architecture in vivo

Autor: A. E. Hildreth, Christine E. Cucinotta, Brendan M McShane, Margaret K. Shirra, Karen M. Arndt

Publikováno v: Nucleic Acids Research

The nucleosome core regulates DNA-templated processes through the highly conserved nucleosome acidic patch. While structural and biochemical studies have shown that the acidic patch controls chromatin factor binding and activity, few studies have elu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2159c2ecff779aff7412c97cf1c998f0
https://pubmed.ncbi.nlm.nih.gov/31226204

The Histone Modification Domain of Paf1 Complex Subunit Rtf1 Directly Stimulates H2B Ubiquitylation through an Interaction with Rad6

Autor: S. Branden Van Oss, Andrew P. VanDemark, B. Franklin Pugh, Annie Heroux, Jongcheol Jeon, Adam D. Wier, Alain R. Bataille, Karen M. Arndt, Kuangyu Yen, Christine E. Cucinotta, Jae-Hoon Kim, In Ja L. Byeon, Vinesh Vinayachandran, Margaret K. Shirra

Publikováno v: Molecular cell. 64(4)

The five-subunit yeast Paf1 complex (Paf1C) regulates all stages of transcription and is critical for the monoubiquitylation of histone H2B (H2Bub), a modification that broadly influences chromatin structure and eukaryotic transcription. Here, we sho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60a0ddc80d0857fb819aba9e04f18a2
https://pubmed.ncbi.nlm.nih.gov/27840029