Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Christine E. Bulawa"'
Autor:
Alistair J. P. Brown, Neil A. R. Gow, A.D.B. Buchan, Carol A. Munro, Christine E. Bulawa, Keith Matthew Henry, Ken Winter, Jeffrey M. Becker
Publikováno v:
Molecular Microbiology. 39:1414-1426
Summary CaCHS1 of the fungal pathogen Candida albicans encodes an essential chitin synthase that is required for septum formation, viability, cell shape and integrity. The CaCHS1 gene was inactivated by first disrupting one allele using the ura-blast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a823265c02d8743d4bed3e4504e4179e
https://doi.org/10.1046/j.1365-2958.2001.02347.x
https://doi.org/10.1046/j.1365-2958.2001.02347.x
Autor:
Darshan S. Sappal, A. Kathleen McClendon, James A. Fleming, Vala Thoroddsen, Kelly Connolly, Corinne Reimer, Ronald K. Blackman, Christine E. Bulawa, Neil Osheroff, Peter Charlton, Laura A. Rudolph-Owen
Publikováno v:
Molecular Cancer Therapeutics. 3:47-58
MLN944 (XR5944) is a novel bis-phenazine that has demonstrated exceptional efficacy against a number of murine and human tumor models. The drug was reported originally as a dual topoisomerase I/II poison, but a precise mechanism of action for this co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4656bbbcaa24c30f00735f4d6eab7130
https://doi.org/10.1158/1535-7163.47.3.1
https://doi.org/10.1158/1535-7163.47.3.1
Autor:
Deborah R. Wysong, Tony Wood, Patrick R. Errada, Tanya Parkinson, Karen J. McGovern, Ian M. Willis, Ronald K. Blackman, Liping Wu, Alexandra E. Gould, Vala Thoroddsen, Timothy D. Ocain, Daniel Kornitzer, Lawrence R. Dick, Patrick Dorr, Christine E. Bulawa, Jing Pan, Ziva Weissman
Publikováno v:
Eukaryotic Cell. 2:256-264
A genetic approach utilizing the yeast Saccharomyces cerevisiae was used to identify the target of antifungal compounds. This analysis led to the identification of small molecule inhibitors of RNA polymerase (Pol) III from Saccharomyces cerevisiae .
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea39b926c7746449d970b5756a2e85ca
https://doi.org/10.1128/ec.2.2.256-264.2003
https://doi.org/10.1128/ec.2.2.256-264.2003
Autor:
Christine E. Bulawa, Ronald K. Blackman, Seth Sadis, Vala Thoroddsen, Eric S. Lightcap, James Fleming
Publikováno v:
Proceedings of the National Academy of Sciences. 99:1461-1466
Although the biochemical targets of most drugs are known, the biological consequences of their actions are typically less well understood. In this study, we have used two whole-genome technologies in Saccharomyces cerevisiae to determine the cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d21b96d5517af97796db7cd567c6dea8
https://doi.org/10.1073/pnas.032516399
https://doi.org/10.1073/pnas.032516399
Autor:
Christine E. Bulawa, Kenneth Winter, Yigal Koltin, Natalia Iartchouk, Perry J. Riggle, Peter T. Borgia
Publikováno v:
Fungal Genetics and Biology. 20:193-203
Borgia, P. T., Iartchouk, N., Riggle, P. J., Winter, K. R., Koltin, Y., and Bulawa, C. E. 1996. The chsB gene of Aspergillus nidulans is necessary for normal hyphal growth and development. Fungal Genetics and Biology 20, 193–203. The chsB gene from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a318dc07d16cc09b12f0d05aa5adfec3
https://doi.org/10.1006/fgbi.1996.0035
https://doi.org/10.1006/fgbi.1996.0035
Autor:
Charles A. Specht, Perry J. Riggle, Phillips W. Robbins, Christine E. Bulawa, Natalia Iartchouk, Yilun Liu, Peter T. Borgia, Carol L. Dodge, David W. Culp, Judith C. Rhodes, Kenneth Winter
Publikováno v:
Fungal Genetics and Biology. 20:153-167
Specht, C. A., Liu, Y., Robbins, P. W., Bulawa, C. E., Iartchouk, N., Winter, K. R., Riggle, P. J., Rhodes, J. C., Dodge, C. L., Culp, D. W., and Borgia, P. T. 1996. ThechsDandchsEgenes ofAspergillus nidulansand their roles in chitin synthesis.Fungal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eccde49549764e7ccbc8ef3a1d27558b
https://doi.org/10.1006/fgbi.1996.0030
https://doi.org/10.1006/fgbi.1996.0030
Autor:
Christine E. Bulawa
Publikováno v:
Annual Review of Microbiology. 47:505-534
In Saccharomyces cerevisiae, three chitin synthases have been detected. Chitin synthases I and II, the products of the CHS1 and CHS2 genes, respectively, are closely related proteins that require partial proteolysis for activity in vitro. In contrast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619524fe19f3c0b78fc4d3f341e91bb8
https://doi.org/10.1146/annurev.mi.47.100193.002445
https://doi.org/10.1146/annurev.mi.47.100193.002445
Publikováno v:
Methods in enzymology. 439
Recent studies implicate a disruption in Rab-mediated protein trafficking as a possible contributing factor to neurodegeneration in Parkinson's disease (PD). Misfolding of the neuronal protein alpha-synuclein (asyn) is implicated in PD. Overexpressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::00978d92146e6cda8a086b4c43c7264b
https://pubmed.ncbi.nlm.nih.gov/18374176
https://pubmed.ncbi.nlm.nih.gov/18374176
Publikováno v:
Methods in Enzymology ISBN: 9780123743114
Recent studies implicate a disruption in Rab‐mediated protein trafficking as a possible contributing factor to neurodegeneration in Parkinson's disease (PD). Misfolding of the neuronal protein α‐synuclein (asyn) is implicated in PD. Overexpressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c552d0dcc39223638e7dfe3a7fa4e1d2
https://doi.org/10.1016/s0076-6879(07)00425-9
https://doi.org/10.1016/s0076-6879(07)00425-9
Autor:
Barbara C. Osmond, Christine E. Bulawa
Publikováno v:
Proceedings of the National Academy of Sciences. 87:7424-7428
In Saccharomyces cerevisiae, the polysaccharide chitin forms the primary division septum between mother cell and bud. Two related enzymes, chitin synthase I and chitin synthase II (UDP-acetamido-2-deoxy-D-glucose:chitin 4-beta-acetamidodeoxyglucosylt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c6a13ac60d5533bb74d98398026c236
https://doi.org/10.1073/pnas.87.19.7424
https://doi.org/10.1073/pnas.87.19.7424