Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Christine E Schaner-Tooley"'
Autor:
Oliver Fiehn, Megan Reed Showalter, Christine E Schaner-Tooley, Reproducibility Project: Cancer Biology
Publikováno v:
eLife, Vol 5 (2016)
The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of selected experiments from a number of high-profile papers in the field of cancer biology. The pap
Externí odkaz:
https://doaj.org/article/0cbe52576bcb4b248b6879479ef6037f
Publikováno v:
Epigenetics & Chromatin, Vol 17, Iss 1, Pp 1-12 (2024)
Abstract Protein and nucleic acid methylation are important biochemical modifications. In addition to their well-established roles in gene regulation, they also regulate cell signaling, metabolism, and translation. Despite this high biological releva
Externí odkaz:
https://doaj.org/article/afb8dd1f1aa04c6884800b2fc50cea8e
Autor:
James P. Catlin, Leandro N. Marziali, Benjamin Rein, Zhen Yan, M. Laura Feltri, Christine E. Schaner Tooley
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-12 (2021)
Abstract N-terminal methylation is an important posttranslational modification that regulates protein/DNA interactions and plays a role in many cellular processes, including DNA damage repair, mitosis, and transcriptional regulation. Our generation o
Externí odkaz:
https://doaj.org/article/f8323dfe4f4248ffbe0b3ca6e3205b7b
Publikováno v:
Journal of Cell Science. 136
N-terminal methylation of the α-amine group (Nα-methylation) is a post-translational modification (PTM) that was discovered over 40 years ago. Although it is not the most abundant of the Nα-PTMs, there are more than 300 predicted substrates of the
Publikováno v:
Methods in Enzymology ISBN: 9780443157721
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfa7daf8d15eefd123ffb00dc6cebab1
https://doi.org/10.1016/bs.mie.2023.02.001
https://doi.org/10.1016/bs.mie.2023.02.001
N-terminal protein methylation (Nα-methylation) is a post-translational modification (PTM) that influences a variety of biological processes by regulating protein stability, protein-DNA interactions, and protein-protein interactions. Although signif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23763f76f45b529d08fd1881af8116f0
https://doi.org/10.1101/2022.10.05.510978
https://doi.org/10.1101/2022.10.05.510978
Autor:
Gehoon Chung, Haley V. Parker, Meghan M. Conner, Daniela R. Falcone, Christine E. Schaner Tooley
Publikováno v:
Transcription
N-terminal methylation (Nα-methylation) by the methyltransferase NRMT1 is an important post-translational modification that regulates protein-DNA interactions. Accordingly, its loss impairs functions that are reliant on such interactions, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757b13be8a27ad407a6eb226c744af34
https://europepmc.org/articles/PMC9467584/
https://europepmc.org/articles/PMC9467584/
Publikováno v:
Journal of Biological Chemistry. 299:104588
Autor:
Jinrong Min, Guangping Dong, Rong Huang, Haley V. Parker, Christine E. Schaner Tooley, Nicholas Noinaj, Brianna Mackie, Dongxing Chen, Cheng Dong
Publikováno v:
J Med Chem
Protein N-terminal methyltransferases (NTMTs) methylate the α-N-terminal amines of proteins starting with the canonical X-P-K/R motif. Genetic studies imply that NTMT1 regulates cell mitosis and DNA damage repair. Herein, we report the rational desi
Autor:
Zhen Yan, James P. Catlin, Benjamin Rein, Leandro N. Marziali, M. Laura Feltri, Christine E. Schaner Tooley
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 11, Pp 1-12 (2021)
Cell Death and Disease, Vol 12, Iss 11, Pp 1-12 (2021)
N-terminal methylation is an important posttranslational modification that regulates protein/DNA interactions and plays a role in many cellular processes, including DNA damage repair, mitosis, and transcriptional regulation. Our generation of a const