Zobrazeno 1 - 10
of 589
pro vyhledávání: '"Christine E, Seidman"'
Autor:
Marlee M. Vandewouw, Ami Norris-Brilliant, Anum Rahman, Stephania Assimopoulos, Sarah U. Morton, Azadeh Kushki, Sean Cunningham, Eileen King, Elizabeth Goldmuntz, Thomas A. Miller, Nina H. Thomas, Heather R. Adams, John Cleveland, James F. Cnota, P Ellen Grant, Caren S. Goldberg, Hao Huang, Jennifer S. Li, Patrick McQuillen, George A. Porter, Amy E. Roberts, Mark W. Russell, Christine E. Seidman, Madalina E. Tivarus, Wendy K. Chung, Donald J. Hagler, Jane W. Newburger, Ashok Panigrahy, Jason P Lerch, Bruce D. Gelb, Evdokia Anagnostou
Publikováno v:
NeuroImage, Vol 297, Iss , Pp 120721- (2024)
Individuals with congenital heart disease (CHD) have an increased risk of neurodevelopmental impairments. Given the hypothesized complexity linking genomics, atypical brain structure, cardiac diagnoses and their management, and neurodevelopmental out
Externí odkaz:
https://doaj.org/article/5e44b9017eb64e49ae2ee4fa20bd3328
Autor:
Francesca Margara, Yiangos Psaras, Zhinuo Jenny Wang, Manuel Schmid, Ruben Doste, Amanda C. Garfinkel, Giuliana G. Repetti, Jonathan G. Seidman, Christine E. Seidman, Blanca Rodriguez, Christopher N. Toepfer, Alfonso Bueno-Orovio
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Cardiomyopathies have unresolved genotype–phenotype relationships and lack disease-specific treatments. Here we provide a framework to identify genotype-specific pathomechanisms and therapeutic targets to accelerate the development of prec
Externí odkaz:
https://doaj.org/article/ef7eab18d6564aba82cb6d5fd83d09e7
Autor:
Gabriela Venturini, Juliana M. Alvim, Kallyandra Padilha, Christopher N. Toepfer, Joshua M. Gorham, Lauren K. Wasson, Diogo Biagi, Sergio Schenkman, Valdemir M. Carvalho, Jessica S. Salgueiro, Karina H. M. Cardozo, Jose E. Krieger, Alexandre C. Pereira, Jonathan G. Seidman, Christine E. Seidman
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
IntroductionChagas cardiomyopathy, a disease caused by Trypanosoma cruzi (T. cruzi) infection, is a major contributor to heart failure in Latin America. There are significant gaps in our understanding of the mechanism for infection of human cardiomyo
Externí odkaz:
https://doaj.org/article/dd5e4d9e31404b4a8296661ca7c6392c
Autor:
Ester Cerdeira Sabino, Lucas Augusto Moysés Franco, Gabriela Venturini, Mariliza Velho Rodrigues, Emanuelle Marques, Lea Campos de Oliveira-da Silva, Larissa Natany Almeida Martins, Ariela Mota Ferreira, Paulo Emílio Clementino Almeida, Felipe Dias Da Silva, Sâmara Fernandes Leite, Maria do Carmo Pereira Nunes, Desiree Sant'Ana Haikal, Claudia Di Lorenzo Oliveira, Clareci Silva Cardoso, Jonathan G Seidman, Christine E Seidman, Juan P Casas, Antonio Luiz Pinho Ribeiro, Jose E Krieger, Alexandre C Pereira
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 10, p e0010725 (2022)
BackgroundChronic Chagas Cardiomyopathy (CCC) usually develops between 10 and 20 years after the first parasitic infection and is one of the leading causes of end-stage heart failure in Latin America. Despite the great inter-individual variability in
Externí odkaz:
https://doaj.org/article/29640fb7a3ec4128a49c82581efd3b9d
Autor:
Theo G. M. Oliveira, Gabriela Venturini, Juliana M. Alvim, Larissa L. Feijó, Carla L. Dinardo, Ester C. Sabino, Jonathan G. Seidman, Christine E. Seidman, Jose E. Krieger, Alexandre C. Pereira
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Chagas disease is a tropical zoonosis caused by Trypanosoma cruzi. After infection, the host present an acute phase, usually asymptomatic, in which an extensive parasite proliferation and intense innate immune activity occurs, followed by a chronic p
Externí odkaz:
https://doaj.org/article/7359d2ff660a4e718bab58592d9d3da5
Autor:
Hao Zhang, K. Lockhart Jamieson, Justin Grenier, Anish Nikhanj, Zeyu Tang, Faqi Wang, Shaohua Wang, Jonathan G. Seidman, Christine E. Seidman, Richard Thompson, John M. Seubert, Gavin Y. Oudit
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 11 (2022)
Background Myocardial iron deficiency (MID) in heart failure (HF) remains largely unexplored. We aim to establish defining criterion for MID, evaluate its pathophysiological role, and evaluate the applicability of monitoring it non‐invasively in hu
Externí odkaz:
https://doaj.org/article/c23e0a1b258047ce88cef7083fc5215d
Autor:
Josh Javor, Jourdan K. Ewoldt, Paige E. Cloonan, Anant Chopra, Rebeccah J. Luu, Guillaume Freychet, Mikhail Zhernenkov, Karl Ludwig, Jonathan G. Seidman, Christine E. Seidman, Christopher S. Chen, David J. Bishop
Publikováno v:
Microsystems & Nanoengineering, Vol 7, Iss 1, Pp 1-8 (2021)
Abstract The structural and functional maturation of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) is essential for pharmaceutical testing, disease modeling, and ultimately therapeutic use. Multicellular 3D-tissue platforms h
Externí odkaz:
https://doaj.org/article/0398ade558ab47ac9a4ec17e5cc09195
Autor:
Alexander Hsieh, Sarah U. Morton, Jon A. L. Willcox, Joshua M. Gorham, Angela C. Tai, Hongjian Qi, Steven DePalma, David McKean, Emily Griffin, Kathryn B. Manheimer, Daniel Bernstein, Richard W. Kim, Jane W. Newburger, George A. Porter, Deepak Srivastava, Martin Tristani-Firouzi, Martina Brueckner, Richard P. Lifton, Elizabeth Goldmuntz, Bruce D. Gelb, Wendy K. Chung, Christine E. Seidman, J. G. Seidman, Yufeng Shen
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-18 (2020)
Abstract Background The contribution of somatic mosaicism, or genetic mutations arising after oocyte fertilization, to congenital heart disease (CHD) is not well understood. Further, the relationship between mosaicism in blood and cardiovascular tiss
Externí odkaz:
https://doaj.org/article/b7f196ef4fc94a1c9c9e2a38f2b299d7
Autor:
Anna B. Meier, Sarala Raj Murthi, Hilansi Rawat, Christopher N. Toepfer, Gianluca Santamaria, Manuel Schmid, Elisa Mastantuono, Thomas Schwarzmayr, Riccardo Berutti, Julie Cleuziou, Peter Ewert, Agnes Görlach, Karin Klingel, Karl-Ludwig Laugwitz, Christine E. Seidman, Jonathan G. Seidman, Alessandra Moretti, Cordula M. Wolf
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103596- (2022)
Summary: Childhood-onset myocardial hypertrophy and cardiomyopathic changes are associated with significant morbidity and mortality in early life, particularly in patients with Noonan syndrome, a multisystemic genetic disorder caused by autosomal dom
Externí odkaz:
https://doaj.org/article/ed0a2036e5be4bbba4144dc8f1dc2f9b
Autor:
Ronny Alcalai, Michael Arad, Hiroko Wakimoto, Dor Yadin, Joshua Gorham, Libin Wang, Elia Burns, Barry J. Maron, William C. Roberts, Tetsuo Konno, David A. Conner, Antonio R. Perez‐Atayde, Jon G. Seidman, Christine E. Seidman
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 17 (2021)
Background Human mutations in the X‐linked lysosome‐associated membrane protein‐2 (LAMP2) gene can cause a multisystem Danon disease or a primary cardiomyopathy characterized by massive hypertrophy, conduction system abnormalities, and malignan
Externí odkaz:
https://doaj.org/article/beaa5a868d0a4b8aa541598c15edec0b