Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Christine E, Genge"'
Autor:
Ling Lee, Christine E Genge, Michelle Cua, Xiaoye Sheng, Kaveh Rayani, Mirza F Beg, Marinko V Sarunic, Glen F Tibbits
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0145163 (2016)
The zebrafish (Danio rerio) is an important organism as a model for understanding vertebrate cardiovascular development. However, little is known about adult ZF cardiac function and how contractile function changes to cope with fluctuations in ambien
Externí odkaz:
https://doaj.org/article/1be7e438ee154b64968236522278151b
Autor:
Ling Lee, Christine E Genge, Michelle Cua, Xiaoye Sheng, Kaveh Rayani, Mirza F Beg, Marinko V Sarunic, Glen F Tibbits
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149741 (2016)
Externí odkaz:
https://doaj.org/article/3c7134bfe5344031b2b548ca179727fa
Autor:
Sanam Shafaattalab, Eric Lin, Marvin Gunawan, Christina M. Hull, Yuki Hobbs, Kaveh Rayani, Christine E. Genge, Tom W. Claydon, Glen F. Tibbits
Publikováno v:
Am J Physiol Regul Integr Comp Physiol
There is significant interest in the potential utility of small-molecule activator compounds to mitigate cardiac arrhythmia caused by loss of function of hERG1a voltage-gated potassium channels. Zebrafish ( Danio rerio) have been proposed as a cost-e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae7a0ab132d84801a0a316bd6371cfd
https://pubmed.ncbi.nlm.nih.gov/31664867
https://pubmed.ncbi.nlm.nih.gov/31664867
Publikováno v:
Physiological Genomics
The teleost-specific whole genome duplication created multiple copies of genes allowing for subfunctionalization of isoforms. In this study, we show that the teleost cardiac Ca2+-binding troponin C (TnC) is the product of two distinct genes: cardiac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf7de1498dd2d73fbca5512ad499a94
https://doi.org/10.1152/physiolgenomics.00074.2013
https://doi.org/10.1152/physiolgenomics.00074.2013
Autor:
Christine E, Genge, Eric, Lin, Ling, Lee, XiaoYe, Sheng, Kaveh, Rayani, Marvin, Gunawan, Charles M, Stevens, Alison Yueh, Li, Sanam Shafaat, Talab, Thomas W, Claydon, Leif, Hove-Madsen, Glen F, Tibbits
Publikováno v:
Reviews of physiology, biochemistry and pharmacology. 171
Zebrafish (Danio rerio) are widely used as vertebrate model in developmental genetics and functional genomics as well as in cardiac structure-function studies. The zebrafish heart has been increasingly used as a model of human cardiac function, in pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::115165cdaf36079866e0b69835975141
https://pubmed.ncbi.nlm.nih.gov/27538987
https://pubmed.ncbi.nlm.nih.gov/27538987
Autor:
Charles M. Stevens, Christine E. Genge, D. Peter Tieleman, Glen F. Tibbits, Gurpreet Singh, William S. Davidson
Publikováno v:
Genome Biology and Evolution
Gene duplication results in extra copies of genes that must coevolve with their interacting partners in multimeric protein complexes. The cardiac troponin (Tn) complex, containing TnC, TnI, and TnT, forms a distinct functional unit critical for the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08114b86d256d7aaf7ea78485b42afa4
https://pubmed.ncbi.nlm.nih.gov/26979795
https://pubmed.ncbi.nlm.nih.gov/26979795
Characterization of Zebrafish Cardiac and Slow Skeletal Troponin C Paralogs by MD Simulation and ITC
Autor:
Gurpreet Singh, Cindy Li, Charles M. Stevens, Kaveh Rayani, Glen F. Tibbits, Filip Van Petegem, Bo Liang, Christine E. Genge, Janine M. Roller, Alison Yueh Li, D. Peter Tieleman
Publikováno v:
Biophysical journal. 111(1)
Zebrafish, as a model for teleost fish, have two paralogous troponin C (TnC) genes that are expressed in the heart differentially in response to temperature acclimation. Upon Ca(2+) binding, TnC changes conformation and exposes a hydrophobic patch th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a15ff33e1755b4143ca8031424f0b9e
https://pubmed.ncbi.nlm.nih.gov/27410732
https://pubmed.ncbi.nlm.nih.gov/27410732
Publikováno v:
Biophysical Journal. 110(3)
Interaction of calcium Ca2+ and troponin C (TnC) is a fundamental process governing regulation of cardiac contractility. Increased affinity of cTnC's regulatory site II for Ca2+ elevates sensitivity, leading to greater force production capabilities.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caff36ef7fc6b1000dd6e0ff77a13bfc
Autor:
Michelle Cua, Mirza Faisal Beg, Ling Lee, Christine E. Genge, Marinko V. Sarunic, Xiaoye Sheng, Kaveh Rayani, Glen F. Tibbits
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149741 (2016)
PLoS ONE
PLoS ONE
The zebrafish (Danio rerio) is an important organism as a model for understanding vertebrate cardiovascular development. However, little is known about adult ZF cardiac function and how contractile function changes to cope with fluctuations in ambien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaa98e0107a248ae11e25d1d3773bfe4
http://europepmc.org/articles/PMC4752491?pdf=render
http://europepmc.org/articles/PMC4752491?pdf=render
Autor:
Ling Lee, Christine E. Genge, Marvin Gunawan, Alison Yueh Li, Glen F. Tibbits, Leif Hove-Madsen, Sanam Shafaat Talab, Thomas W. Claydon, Kaveh Rayani, Eric Lin, Xiaoye Sheng, Charles M. Stevens
Publikováno v:
Reviews of Physiology, Biochemistry and Pharmacology ISBN: 9783319438139
Zebrafish (Danio rerio) are widely used as vertebrate model in developmental genetics and functional genomics as well as in cardiac structure-function studies. The zebrafish heart has been increasingly used as a model of human cardiac function, in pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f633388e69be65ea5311d3848c9af6de
https://doi.org/10.1007/112_2016_5
https://doi.org/10.1007/112_2016_5
