Výsledky vyhledávání - "Christine Dolde"

A CK1 FRET biosensor reveals that DDX3X is an essential activator of CK1ε

Autor: Christine Dolde, Joachim Bischof, Ulrich Baumann, Beat Suter, Simon Grüter, Anna Montada, Hubert Kalbacher, Christian Peifer, Jakob Halekotte, Uwe Knippschild

Publikováno v: Dolde, Christine; Bischof, Joachim; Grüter, Simon; Montada, Anna; Halekotte, Jakob; Peifer, Christian; Kalbacher, Hubert; Baumann, Ulrich; Knippschild, Uwe; Suter, Beat (2018). A CK1 FRET biosensor reveals that DDX3X is an essential activator of CK1ε. Journal of cell science, 131(1) Company of Biologists Limited 10.1242/jcs.207316
Journal of Cell Science

Casein kinase 1 (CK1) plays central roles in various signal transduction pathways and performs many cellular activities. For many years CK1 was thought to act independently of modulatory subunits and in a constitutive manner. Recently, DEAD box RNA h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd6ec14e31a265b6e363a9576610fe7b

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RNA Helicase DDX3 Is a Regulatory Subunit of Casein Kinase 1 in Wnt–β-Catenin Signaling

Autor: Cristina Maria Cruciat, Hendrik C. Korswagen, Bisei Ohkawara, Christine Dolde, Carmen Reinhard, Reinoud E. A. de Groot, Christof Niehrs

Publikováno v: Science Magazine, 339(6126), 1436-1441. American Association for the Advancement of Science (AAAS)

Casein kinase 1 (CK1) members play key roles in numerous biological processes. They are considered "rogue" kinases, because their enzymatic activity appears unregulated. Contrary to this notion, we have identified the DEAD-box RNA helicase DDX3 as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77febce704d4d1fcc620b146e463d8de
https://doi.org/10.1126/science.1231499

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HMG-I/Y in human breast cancer cell lines

Autor: Linda M.S. Resar, Christine Dolde, Chung Cho, Mita Mukherjee

Publikováno v: Breast Cancer Research and Treatment. 71:181-191

The HMG-I/Y gene encodes the HMG-I and -Y architectural, chromatin binding proteins originally identified based on their association with chromosomal DNA. HMG-I/Y proteins bind to AT-rich regions in chromosomal DNA and alter gene expression. Increase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a58aa6b6e356592e1575090a976f19
https://doi.org/10.1023/a:1014444114804

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Cross talk between cellular regulatory networks mediated by shared proteins

Autor: Jiongming Lu, Christine Dolde, Beat Suter

Publikováno v: Dolde, Christine; Lu, Jiongming; Suter, Beat (2014). Cross talk between cellular regulatory networks mediated by shared proteins. Advances in Biology, 2014, pp. 1-12. Hindawi Publishing Corporation 10.1155/2014/274196
Advances in Biology

Moonlighting proteins mediate cross talk between different pathways and cellular control networks. Sometimes, they even coordinate subsequent steps in the same pathway. For thisOutlook paperwe asked the question, which cellular processes employ multi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91083eb1b1acb8da13fc5ebf1b89d449
https://boris.unibe.ch/68148/1/Dolde_Lu_Suter.pdf

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c-Myc transactivation of LDH-A : Implications for tumor metabolism and growth

Autor: Richard A. Jungmann, Gerard Dang, Chi V. Dang, Christine Dolde, Hyunsuk Shim, Brian C. Lewis, Riccardo Dalla-Favera, Chyi Sun Wu

Publikováno v: Proceedings of the National Academy of Sciences. 94:6658-6663

Cancer cells are able to overproduce lactic acid aerobically, whereas normal cells undergo anaerobic glycolysis only when deprived of oxygen. Tumor aerobic glycolysis was recognized about seven decades ago; however, its molecular basis has remained e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f81737468a8301a807db5ea556b2833
https://doi.org/10.1073/pnas.94.13.6658

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[Untitled]

Autor: Chi V. Dang, Christine Dolde, Hyunsuk Shim, Brian C. Lewis, Gerard Dang

Publikováno v: Journal of Bioenergetics and Biomembranes. 29:345-354

The ability of cancer cells to overproduce lactic acid aerobically was recognized by Warburg about seven decades ago, although its molecular basis has been elusive. Increases in glucose transport and hexokinase activity in cancer cells appear to acco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58f7c6259fc3f0872532e45d724fb91f
https://doi.org/10.1023/a:1022446730452

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A link between c-Myc-mediated transcriptional repression and neoplastic transformation

Autor: John Barrett, Chyi S. Wu, Christine Dolde, Linda A. Lee, Chi V. Dang

Publikováno v: Journal of Clinical Investigation. 97:1687-1695

Recent studies indicate that the transcription factor c-Myc contributes to oncogenesis by altering the expression of genes involved in cell proliferation, but its precise function in neoplasia remains ambiguous. The ability of c-Myc to bind the seque

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::024e4ddf74011c31cc379a2cf4bbd43e
https://doi.org/10.1172/jci118595

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LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling

Autor: Michael Boutros, Cristina Maria Cruciat, Andrei Glinka, Christof Niehrs, Christine Dolde, Nadine Kirsch, Ya Lin Huang, Dierk Ingelfinger, Olga Kazanskaya

R-spondins are secreted Wnt signalling agonists, which regulate embryonic patterning and stem cell proliferation, but whose mechanism of action is poorly understood. Here we show that R-spondins bind to the orphan G-protein-coupled receptors LGR4 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f973da4757182fcc9aec9944887df8e9
https://europepmc.org/articles/PMC3185347/

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HMG-I/Y, a New c-Myc Target Gene and Potential Oncogene

Autor: Linda M.S. Resar, Lisa Wood, Tracie E. Bunton, John Williams, Yi Xu, Mita Mukherjee, Joseph F. Maher, Christine Dolde

The HMG-I/Y gene encodes the HMG-I and HMG-Y proteins, which function as architectural chromatin binding proteins important in the transcriptional regulation of several genes. Although increased expression of the HMG-I/Y proteins is associated with c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b06900e8dcbf790f31afe5d000dd9c1
https://europepmc.org/articles/PMC86000/

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Myc Target Genes in Neoplastic Tranformation

Autor: Chi V. Dang, Christine Dolde, Hyunsuk Shim, Q. Li, Brian C. Lewis, Chyi Sun Wu, Yoon S. Chun

Publikováno v: Current Topics in Microbiology and Immunology ISBN: 9783642645600

Deregulated expression of the c-myc oncogene as a consequence of specific genetic alterations is sine-qua-non for certain B-cell neoplasms. Dissection of the c-Myc protein over the last decade reveals a structural organization that is characteristic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c6e760439832fe5e6ffecaa97b5269fc
https://doi.org/10.1007/978-3-642-60801-8_18

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