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Autor:
Jan T. Wagner, W. Mühlberg, H. J. Heppner, Andreas Pahl, S. Wicklein, Thomas Bertsch, Cornel C. Sieber, Iouri Bachmakov, Martin F. Fromm, Christine Diewald, C. Dragonas
Publikováno v:
European Journal of Clinical Pharmacology. 64:367-372
Digitoxin is a known substrate of the efflux pump P-glycoprotein (gene name: ABCB1). P-glycoprotein expression was shown to be modulated by single nucleotide polymorphisms in the ABCB1 gene, but it remains unclear whether these polymorphisms influenc