FOXO1 regulates L-Selectin and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase

Autor: Christine Denoyelle, Nicolas Cagnard, Vladimir Lazar, Anne Dubart-Kupperschmitt, Georges Bismuth, Stéphanie Fabre, Florent Carrette, David A. Fruman, Marianne Mangeney, Valérie Lang, Jing Chen, Monique Semichon

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2008, 181 (5), pp.2980-9
Journal of Immunology, 2008, 181 (5), pp.2980-9
Scopus-Elsevier

In T cells, the PI3K pathway promotes proliferation and survival induced by Ag or growth factors, in part by inactivating the FOXO transcription factor 1. We now report that FOXO1 controls the expression of L-selectin, an essential homing molecule, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce312e1c799476d1405832208bbafe19
https://pubmed.ncbi.nlm.nih.gov/18713968