Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Christine D. LaRocca"'
Autor:
W.Andrew Tucker, Danny A Fuller, Kevin D. Raney, Carole J. Boylan, Ashley S Ross, Thomas E. Goodwin, William L. Current, John C Byrd, Clint B Edwards, Jennifer L. Green, Christine D. LaRocca
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:2205-2208
New analogues of the venerable antimalarial drug primaquine have been synthesized and bioassayed in vivo against Pneumocystis carinii, a life-threatening infection common among immunosuppressed patients. Two of these new compounds are significantly m
Autor:
Omer L. Shedd, Heidi M. Crane, Joseph W. Thompson, Christine D. LaRocca, Brock K. King, Charles C. Harmon, Robert L. Lile, Thomas E. Goodwin, Shari G. Orlicek, John S. Swanson, Ronald W. Pelton, Phyllis O. Eason, Kimberley R. Cousins, Timothy E. Freyaldenhoven
Publikováno v:
Journal of Carbohydrate Chemistry. 17:323-339
Maytansine (1) is a macrocyclic natural product with significant anti-cancer activity. A derivative (4) of D-glucal is converted to a model compound (10) for the lower periphery of the maytansinoid ring via alkylation at C-6 using an allylic sulfide
Publikováno v:
Dental Clinics of North America. 41:669-679